Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"alternative end joining"”.
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Dna Polymerase Θ (Polq) and The Cellular Defense Against Dna Damage
… polymerase activity of POLQ. Using a DNA break end joining assay in cells, the repair of DNA ends with long 3′ single-stranded overhangs was monitored. End joining events that retained much of the overhang were dependent on POLQ, and independent of Ku70. To analyze this repair function in more …
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Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome
… breaks (DSB) with unligatable dirty ends, along with more frequent oxidized bases and single-strand breaks (SSB). While nonhomologous end joining and homologous recombination are major DSB repair pathways which have been extensively characterized over the past decades, contribution of …
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Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases
… between DSB repair via error-free non-homologous end joining (EF-NHEJ), mutagenic end joining (mut-EJ), alternative end joining (alt-EJ), homologous recombination (HR), and single strand annealing (SSA) at a single break created within individual cells by CRISPR-Cas9. We demonstrate that DSB-Prism …
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Altered Kinetics of Non-Homologous End Joining Mediated DNA Repair in Mouse Models of Aging and Leukemia
… of these DSB are repaired by Non-homologous end joining (NHEJ). Unrepaired DSB can lead to genomic instability resulting in cell cycle arrest, apoptosis, and mutations. Thus, delineating this DNA repair process is important in understanding the molecular mechanisms of aging and malignant …