Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 3192 for “"alterations"”.
-
Morphological alterations in frontotemporal dementia:
The present thesis explores alterations in brain morphology in the neurodegenerative disorder of frontotemporal dementia (FTD). With the aim to improve the clinical diagnostics of FTD, we explored the diagnostic potential of measuring morphological alterations in the white matter by diffusion …
-
Investigating mitochondria alterations in esophageal pathologies
… and the clinical significance of mitochondrial alterations in EoE. We hypothesize that altered mitochondrial biology contributes to EoE pathogenesis and promote inflammatory signaling in esophageal epithelial cells. To investigate the role of mitochondria in esophageal epithelium under EoE …
-
Structural Aspects of Clay Mineral Alterations
Made available in DSpace on 2014-12-09T20:34:22Z (GMT). No. of bitstreams: 1 6612322.pdf: 3152395 bytes, checksum: ec585eed0eaf407aa79cd2e74e444e39 (MD5) Previous issue date: 1966
-
Mental Construal and Alterations in Emotional Memory
<p>Psychological distancing refers to a shift from a psychologically immersed perspective that involves thinking about the details of an event (concretely) or stepping back from it and watching the event from an outside point of view (abstractly)––this can help individuals change how they feel …
-
Metabolic alterations in patients with heart disease
Despite major advances in therapies, chronic heart failure (CHF) and hypertrophic cardiomyopathy (HCM) are still associated with significant morbidity and mortality. These patients often have a significant limitation in their exercise capacity. We showed that there are widespread abnormalities of …
-
Cardiovascular Functional Alterations in Chronic Kidney Disease
… striking multitiered, multi-dimensional complex alterations encompassing the entire oxygen transport system. Complex interactions between target organ systems involving alterations of the heart, vasculature, musculoskeletal and respiratory systems occur in Chronic Kidney Disease (CKD). Failure of …
-
Genetic Alterations in Advanced Head and Neck Cancer
Genetic alterations of the PTEN gene located on chromosome 10q23 have been found in different neoplasms. In squamous cell carcinoma of the head and neck (SCCHN) loss of heterozygosity (LOH) at 10q has been described to be associated with poor prognosis. Moreover, genetic instability of …
-
Age-associated alterations in head and neck cancer
… dynamics, and that targeting age-associated alterations in the carcinoma cell, immune, or stromal compartments could serve as viable avenues for therapeutic intervention to improve outcomes for older HNSCC patients.
-
Genetic Alterations Associated with Attention Deficit Hyperactivity Disorder
… may lead to long term developmental cognitive alterations. Previous literature has identified ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 (ST3GAL3) as a possible genetic component underlying ADHD. This study uses Loop Mediated Isothermal Amplification (LAMP) to amplify the wild type of …
-
Forebrain Noradrenergic Alterations and Anxiety After Myocardial Infarction
… were designed to test the hypothesis that alterations in noradrenergic transmission in the forebrain contribute to the development of anxiety disorders and arrhythmia susceptibility after MI. Using a rat coronary artery ligation model of MI, we first assessed MI-induced changes in …
-
Dissecting the genomic and epigenomic alterations underlying glioblastoma
… much is known about the recurrent coding alterations and the role of GSCs in GBM, we still have a poor understanding of the contribution of non-coding alterations and complex structural variants (SVs) to GBM pathogenesis, as well as the role of key NSC transcription factors such as SOX2 …
-
Analysis of alterations in the human cancer genome
… characterization techniques measure somatic alterations in a cancer sample in units of genomes (DNA mass). The meaning of such measurements is highly dependent on the tumors purity and its overall ploidy; they are hence complicated to interpret and compare across samples. Ideally, copy-number …
-
Deconvolute Brain Tumor Genomic Alterations Based On Dna Methylation
… between epigenetic signature and genetic alterations is poorly understood. For example, mutation of isocitrate dehydrogenase (<em>IDH</em>) is associated with genome-wide hypermethylation of CpG islands in gliomas. But other subtype-associated alterations, including telomerase reverse …
-
Immune cell alterations in mouse models of prostate cancer
… were observed within the tumour mass. Similar alterations were observed in the prostate-specific Pten knockout mice which develop advanced prostate adenocarcinoma. Interestingly, evidence of immune activation, such as an increased frequency of activated T cells, was detected in the tumour …
-
Modeling Alterations In Nociception Following Repeated Vaso-Occlusive Episodes
… For males, ET-1 exposure resulted in systemic alterations in sensitization, down-regulation in ETB receptor expression and changes in ETB:ETA receptor ratio. Pretreatment with morphine or the androgen receptor antagonist, flutamide, attenuated ET-1 induced sensitization in males. For females, …
-
Alterations in lymphocyte signalling produced by exposure to mercury
The effects of 1 min – 4 hr exposures to mercuric chloride (HgCl2), methyl mercuric chloride (CH3HgCl), p-chloromercuribenzoate (p-CMB) and ethylmercurithiosalicylate (TMS) on cell viability and kinetics of cell death, microtubules, F-actin, CD3 receptor expression, protein tyrosine phosphorylation …
-
Immunopathological and Structural Alterations in Difficult to Control Asthma
… study the relationship between histopathological alterations and clinical control in patients with different severities of asthma. To study this, a detailed immunohistochemical analysis was performed on lung biopsies obtained from moderate asthmatics (n = 24 in Paper I), severe asthmatics (n = 25 …
-
Alterations in executive functioning induced by repeated amphetamine exposure
Chronic exposure to psychostimulants such as amphetamine (AMPH) can induce long-term disruptions in cognition via actions on prefrontal cortex dopamine. Previous work has shown that two types of executive functions, set shifting and working memory (WM), are disrupted by AMPH sensitization and that …
-
Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
… and matching benign livers were used to compare alterations in 5-hmC level, if any, in tumors. Mouse models of HCC were also used to further validate the results obtained from human specimens. We observed remarkable decrease in global 5-hmC content in HCCs of both human and rodent origin using …
Page 1 of 160