NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 2 of 2 for “"alt‑NHEJ"”.

  1. UNRAVELING THE MOLECULAR MECHANISM OF BRCA2-POLTETA INTERPLAY IN PREVENTING SSDNA GAP ACCUMULATION DURING DNA REPLICATION

    RAMIREZ OTERO, MIGUEL ANGELUniversità degli Studi di Milano2023

    … encoded by POLQ, plays a critical role in alternative non-homologous end joining (alt-NHEJ), a backup pathway for repairing DNA double-strand breaks in the absence of homologous recombination. The synthetic lethal relationship between POLQ and BRCA1/2 has been well-established, but the …

    milano Repository record

  2. Mechanistic Understanding of the Role of TRF1 in Telomere Replication

    Yang, Zhe

    … in cells with FokI-induced telomeric DSBs and in alternative lengthening of telomeres (ALT) cells, which have spontaneous telomeric damage. BIR of telomeric DSBs competes with PARP1-, LIG3-, and XPF-dependent alternative non-homologous end joining (alt-NHEJ). Collectively, these findings indicate …

    rockefeller Repository record