Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"alpha7beta1 integrin"”.
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An Alpha7beta1 Integrin-Based Treatment of Muscular Dystrophy
… interactions in adult skeletal muscles are the alpha7beta1 integrin complex and the dystrophin protein complex. Both act as molecular chains that connect the actin cytoskeleton to laminin in the basal lamina. Disruption of either linkage system leads to muscular dystrophy in humans and mice. To …
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The Alpha7beta1 Integrin in Skeletal Muscle and Muscular Dystrophy
… thesis examines the effects of enhancing alpha7 integrin on cellular functions and global gene expression in myoblasts and skeletal muscle. I found that 3-fold more alpha7 integrin promotes myoblast adhesion, proliferation and resistance to apoptosis without affecting differentiation. In …
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Molecular Enhancement of Alpha 7 Integrin to Ameliorate Muscular Dystrophy
… to the cytoskeleton in skeletal muscle. The alpha7beta1 integrin also links laminin in the extracellular matrix to actin in skeletal muscle. It has been shown that transgenic overexpression of the alpha7 integrin chain in mdx/utr (-/-) mice, a model for Duchenne muscular dystrophy, …
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The α7β1 integrin accelerates exercise-induced myogenesis
… transgenic overexpression of the α7β1 integrin can protect against exercise induced-injury and promote the appearance of multipotent mesenchymal-like (Sca-1+CD45-) stem cells in skeletal muscle. PURPOSE: The purpose of this study was to determine if overexpression of the α7β1 integrin …