Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"alpha-synuclein (Asyn)"”.
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Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease
… we demonstrate that a higher concentration of alpha synuclein (aSyn) and phosphorylated tau181 (p-tau181) EVs are present in PD plasma when compared to plasma from HCs. Further research is needed to determine if correlation exists between EV concentration and clinically determined values.
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Graphene Microelectrode Arrays to Combine Electrophysiology with Fluorescence Imaging of Amyloid Proteins
… and tau, and for PD the implicated protein is $\alpha$-synuclein (aSyn). The motivation for this work is to develop and use physical techniques to better understand the role of amyloid proteins in neurodegenerative diseases. Two techniques used in amyloid research are fluorescence microscopy, to …
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Localised Dosing and Nanodetection Using a Novel Scanning Ion Conductance Microscope and Its Application to Alzheimer's Disease
… of antibodies that bind to Abeta or alpha-synuclein (Asyn)peptides depends on the measurement of oligomer-induced abnormal calcium homeostasis in single astrocytes. The method was shown to work at physiological concentrations of oligomers. A series of experiments measuring the …
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Understanding the membrane biophysics of alpha-Synuclein and its role in membrane curvature induction and structural remodeling
Alpha-Synuclein (aSyn) is a 140 amino acid, intrinsically disordered protein that adopts an extended amphipathic alpha-helical structure upon binding the membrane. aSyn is the major proteinaceous component of insoluble fibrillar Lewy bodies, a hallmark of Parkinson's disease (PD). The precise roles …
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Mechanistic modeling of alpha-synuclein aggregation and brain pharmacokinetics for drug development in neurodegeneration
… the work focuses on the mathematical modeling of alpha-synuclein (aSyn) aggregation dynamics under in vitro conditions—a molecular process relevant to Parkinson’s disease (PD) and other synucleinopathies. Building on in vitro aggregation studies and chemical kinetic models, we develop a …
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Rational Design of Antibodies against Tau and Alpha-Synuclein
… proteins such as amyloid beta (Abeta), tau, and alpha-synuclein (aSyn). Although these protein deposits correlate to some extend with disease progression and cognitive decline, increasing evidence suggests that small intermediate aggregate species called oligomers are the primary driver of …
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… neuronal dysfunction, with a specific focus on alpha-synuclein (aSyn), a presynaptic protein centrally involved in PD pathology. Biophysical analyses revealed that both 24S-HC and 27-HC bind directly to aSyn with higher affinity than cholesterol. Interestingly, despite this binding, 27-HC does …
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Structural Polymorphism of Alpha-Synuclein in Conditions Resembling the Cellular Environment
… the aggregation of a small presynaptic protein, alpha-synuclein (aSyn), from its functional disordered form into amyloid fibrils with characteristic β-sheet structure, as being at the centre of PD. However, many unanswered questions remain with regards to the aSyn aggregation mechanism in neurons …
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Microfluidic Approaches for Investigating Aggregated Forms of Disease-Related Proteins
… as intrinsically disordered proteins, e.g. $\alpha$-Synuclein (aSyn) and A$\beta$40, and their respective oligomers. Another advantage of this method is its applicability for studies of brain aSyn from transgenic overexpressing mice (OVX). Furthermore, I explore the potential of IDS for the …