Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"alpha-synuclein (AS)"”.
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Structure determination of proteins and protein aggregates by magic-angle spinning solid-state NMR
… and do not produce X-ray diffracting crystals. As SSNMR begins to realize this potential, new structure determination techniques will be important in enable SSNMR to investigate ever larger and more complicated systems. Alpha-synuclein (AS) is the primary protein component of Lewy bodies, the …
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Structure, conformational dynamics and formation of large amyloids: the case of alpha-synuclein fibrils
… atomic level structural information of the alpha-synuclein (AS) fibrils and the mechanism of their formation; We first investigated the effect of protein deuteration and 1H decoupling optimization to maximize the resolution and sensitivity of biomolecular solid-state NMR; We then applied …
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Protein -Protein Interactions of Synucleins: Implications for Normal Function and Neurodegenerative Disease
Synucleins are a family of three small, highly conserved proteins expressed presynaptically in the central and peripheral nervous systems. The three isoforms, alpha, beta, and gamma, are most homologous in their N-terminal ∼100 residues, which form a lipid-binding amphipathic alpha-helix. …
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The prion-like properties of assembled human alpha-synuclein
… of many age-related neurodegenerative diseases is the presence of proteinaceous inclusions in nerve cells and glial cells. Alpha-synuclein is the main component of the inclusions of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, as well as of rarer diseases, …
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Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein
… als Lewy- Körper bezeichneten blagerungen ist das presynaptische, 140-Reste umfassende Protein alpha-Synuclein (aS). Bisher wurden drei genetische Mutationen in aS identifiziert, welche in Zusammenhang mit der Parkinson-Krankheit stehen. In vitro, kann die Aggregation von aS über …
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… of two missense mutations (A53T and A30P) in alpha -synuclein that are genetically linked to Parkinson's disease, together with alpha -synuclein being the major component in Lewy bodies, has generated extensive interest in alpha -synuclein as a key component in neurodegenerative diseases. In …
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Novel sustained release formulation of leveodopa-dendrimer conjugate
Fibrillation of alpha synuclein (AS) leading to the formation of Lew body has been ubiquitously reported in many geriatrics disorders such as Parkinson's disease (PD), Alzheimer's disease, and other neurodegenerative disorders. Therefore, any substance inhibiting or reducing fibrillation of alpha …