Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"alpha-catenin"”.
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Force-dependent changes in alpha-catenin conformation
… reinforce stressed intercellular contacts. α-Catenin is an identified force sensor within cadherin complexes. Mechanical force regulates binding of α-catenin to the actin-binding protein vinculin and to the actin cytoskeleton itself. This regulation is accomplished through distinct …
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Structural Basis of Adhesion Activation of the Cadherin-Catenin Complex
… binding domains, followed by a single-pass alpha-helical transmembrane domain, then a C-terminal intrinsically disordered cytoplasmic tail. The tail is bound to alpha-catenin, beta-catenin, and p120-catenin, together known as the cadherin-catenin complex. Through alpha-catenin, the complex …
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Uncovering novel actions of numb and aryl hydrocarbon receptor in the pituitary
… mice, an additional intermediate lobe produces alpha melanocyte-stimulating hormone (␣MSH) from alternative cleavage of the Pomc gene. The pituitary modulates many of these processes in a dynamic manner in response to physiological need. This includes not only adjusting hormone secretion, but …
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Rapid Functional Dissection of Genetic Networks Via RNAi In Mouse Embryos
… tissue. Taking the adherens junction protein α-catenin as a paradigm, this approach was used to uncover new insights into its role as a widely expressed tumor suppressor and regulator of epithelial integrity. Using simultaneous gene depletion I uncovered physiological interactions between …
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Structual Visualization of Cytoskeletal Force Tranduction
… and the force-activated cell adhesion protein α-catenin.In vitro reconstitution and cryo-electron microscopy reveal myosin force-evoked superhelical F-actin spirals. Three-dimensional reconstruction and variability analysis uncover extensive asymmetric remodeling of F-actin's helical lattice. …
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A Platform for Analyzing Force Sensitivity and Multivalency in Actin Networks
… of the critical cell-cell adhesion protein α-catenin, a model force-sensitive ABP. We find that myosin forces increase homodimeric α-catenin's engagement of filament bundles, particularly smaller bundles embedded within networks. This activity is largely abrogated in a force-sensing deficient …
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Die funktionelle Bedeutung des Coxsackie- und Adenovirus Rezeptors (CAR) im kolorektalen Karzinom
… DLD1 mit CAR-Inhibition identifizierte α-Catenin als das am stärksten regulierte Gen. Obwohl keine direkte Interaktion beider Proteine detektiert werden konnte, führte eine stabile Re-Expression von α-Catenin in DLD1 mit stabiler CAR-Inhibition zu einer deutlichen Reduktion von …