Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"alpha-actin"”.
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Proteomic analysis of the olfactory mucosa, thoracic aorta, urinary bladder, and descending colon of smooth muscle alpha actin null mutant mice
Smooth muscle alpha actin is one of six mammalian isoforms and the predominant isoform in vascular smooth muscle. In mice and humans lacking functional SMAA, pathophysiological changes have been identified in the aorta, bladder, colon, and olfactory ensheathing cell population in the olfactory …
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Effects of low and high intensity exercises on serum mean values of myoglobin and heart-type fatty acid-binding protein in athletes
… suitable for early diagnosis of muscle injury. [alpha]-actin is a new and reliable marker of skeletal muscle damage. Discrimination between skeletal and cardiac muscle damage can be done by the combined use of [alpha]-actin and troponin I (TnI). Troponin I (TnI) is only expressed in striated …
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The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… Non-muscle MHC respectively with Smooth muscle-alpha Actin (SM-AA). The endothelium appeared to be a significant component of VEGF alterations to contractile function and MHC:SM-AA re-organization and this was mediated in part through VEGF stimulation of the NO pathway. Hypoxic acclimatization …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… variants in the gene encoding smooth muscle alpha-actin, ACTA2, were modeled with Acta2-/- mice. I found that the ascending aorta and aortic root in these mice become significantly dilated over time. Acta2-/- mice are hypotensive, and increasing the blood pressure with a pharmaceutical and …
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Differentially expressed genes in aortic cells from atherosclerosis-resistant and atherosclerosis-susceptible pigeons
… to produce energy. Myosin light chain kinase and alpha actin were exclusively expressed by the SR SMC, whereas beta actin and collagen were dominant in the WC. Because of the compressed in vitro time frame compared with in vivo development, it was not obvious whether insufficient ATP synthesis is …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… Light Chain Kinase (MLCK) and Smooth Muscle Alpha Actin (SMαA) colocalization data shows that ET-1 promotes contractile dedifferentiation in normoxic but not hypoxic MCAs in a PKC, CaMKII, and p38 dependent manner. These results support the notion that chronic hypoxia has long term effects …
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Comparison of human and mouse AKR1C enzymes: implications for modeling human cancer
… of the key steroids androstenedione, 5\(\alpha\)-dihydrotestosterone, progesterone and estrone was performed by 4 of the murine isoforms. However, unlike humans, no AKR1C isoforms were detected in murine prostate, testes, uterus and haemopoietic progenitors. This study exposes significant …
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Analysis of Cellular Factors Involved in Adeno-Associated Virus Type 2 Entry
… upon AAV binding were enriched in activated PKC alpha, actin and dynamin. Treatment with dynosore, expression of dominant negative dynamin 2, or an HSPG construct lacking the PKC recruitment domain greatly diminished the size of macropinosomes and AAV internalization. Finally, silencing of …
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Molecular genetic investigation of autosomal dominant muscular dystrophy
… skeletal muscle genes slow troponin (TNN/1), alpha actin (ACTA1), and (3-tropomyosin (TPM2) were isolated for use in the fluorescent in situ hybridisation localisation of these genes on the cytogenetic map of the human genome. The localisation of these genes made them potential candidates for …
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The Impact of Ventricular Assist Device Prior to Transplantation on Morphological Parameters in Cardiac Allografts /// Въздействие на вентрикуларните помощни устройства преди трансплантация върху морфологичните параметри при сърдечните алографи
… histology and immunohistochemistry (CD31, alpha actin). Results: In the study population as a whole there is a positive correlation between C3d and C4d (p=0.007), with 64% concordant cases (107 negative and 33 positive out of 220 in total). Analyzing the two groups separately a significant …
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Smooth Muscle Hyperplasia Due to Acta2/Myh11 Mutations: Identification of Novel Pathology and Pathways Leading to Aneurysms and Diverse Vascular Occlusive Diseases
… in smooth muscle cell (SMC) specific ACTA2 (á-actin) and MYH11 (â-myosin heavy chain) cause diffuse and diverse vascular diseases, including thoracic aortic aneurysms and dissections (TAAD) and early onset coronary artery disease and stroke. The mechanism by which these mutations lead to …