Global ETD Search
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Showing 1 to 5 of 5 for “"alpha-Galactosylceramide"”.
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… of the effectiveness of a synthetic glycolipid, alpha-Galactosylceramide (-GalCer), as an adjuvant for mucosal immunization with peptide and protein antigens, by oral and intranasal routes, to prime antigen-specific immune responses in multiple systemic and mucosal compartments. The adjuvant …
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… adaptive immunity. The synthetic glycolipid alpha-Galactosylceramide (α-GalCer) effectively activates the innate immune mediating NKT cells to produce cytokines and activate downstream immune cells, resulting in development of humoral and cell mediated immune responses to co-administered …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… the marine sponge, <em>Agelas mauritianus</em>, alpha-Galactosylceramide (α-GalCer) potently activates iNK-T cells. Within a few hours after activation, iNK-T cells produce high quantities of T<sub>H</sub>1 and T<sub>H</sub>2 type cytokines, thus shape subsequent adaptive immunity towards …
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Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
<p>Human Papillomavirus (HPV) induced cancers continue to affect millions of women worldwide, with the five year survival rate hovering just under 60% in some demographics. Therefore there is an unmet need to develop effective, yet, easily administered therapies to treat established HPV genital …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… of antigens, analogs of the model compound alphaGalCer (KRN-7000) have been synthesized. These include fluorophore-appended 6”-amino-α-galactosylceramides and N-alkenoyl GSLs, such as PBS-57, a potent alphaGalCer surrogate useful in NKT cell stimulation studies. A nonantigenic …