Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"alpha-5-beta-1"”.
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The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
… Fibronectin fragment (FN-f) stimulation of the &alpha5&beta1 integrin increases intracellular levels of ROS in chondrocytes, while antioxidants block FN-f stimulated MMP-13 expression, demonstrating ROS are critical regulators of this pathway. However, the means by which ROS regulate this pathway …
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Zur Rolle von C5 und [alpha]5[beta]1-Integrin für die Entstehung von renaler Fibrose und mögliche therapeutische Konsequenzen
… C5-deficient-mice as well as specific C5aR-and alpha5beta1-Integrin antagonists to detect the influence of the anaphylatoxin C5a and alpha5beta1-Integrin in the development of renal tubulo-interstitial fibrosis. First, we induced a unilateral ureterobstruction (UUO) in C5 deficient mice and …
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Immunhistochemische Untersuchung von Integrinen auf Endothelzellen in Abhängigkeit von der extrazellulären Matrix und von verschiedenen stimulierenden Substanzen
… data show that EC adhere to fibronectin via the alpha 5 beta 1 integrin and to vitronectin and fibrin via the alpha v beta 3 integrin. EC on vitronectin produce endogenous fibronectin which they secrete as an additional matrix protein and to which they adhere via alpha 5 beta 1 integrins. After …
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Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility
… of the fibronectin (FN) receptor integrin, alpha-5-beta-1 in CD9 mediated cell motility. Our findings show that CD9 is in molecular complex with alpha-5-beta-1 and that CD9 promoted migration can be completely blocked by an alpha-5-beta-1 function blocking antibody. Further studies revealed …
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Progression of chondrocyte signaling responses to mechanical stimulation in 3-D gel culture
… culture. At early days in culture, blocking [alpha]v[beta]3 integrin abolished dynamic compression stimulation of proteoglycan synthesis, independent of effects in free-swell culture, while blocking [alpha]5[beta]1 integrins abolished the effect of compression only when blocking in free-swell …
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The role of the P2Y2 nucleotide receptor in salivary gland regeneration
… and metalloproteinases (ADAM10/ADAM17) and the [alpha-5 beta-1] integrin/Cdc42 Rho GTPase signaling pathway. This study sheds light on the P2Y2R as a target in salivary gl and reconstitution strategies and introduces [alpha-5 beta-1] integrin and Cdc42 as novel downstream components in the P2Y 2 …
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Expression et signalisation des intégrines des cellules glomérulées de la glande surrénale de rat : implication de composantes de la matrice extracellulaire, d'hormones et de canaux ioniques
… transmembranaires formées d’une sous-unité alpha (a) et d’une sous-unité bêta (beta). La liaison des intégrines à leurs ligands (les protéines de la matrice extracellulaire) active des voies de signalisation intracellulaire menant, entre autres, à la prolifération, à la migration et à la …
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Forces Generated by Cell Intercalculation Tow Epidermal Sheets in Mammalian Tissue Morphogenesis
… in vivo show that this mechanism requires alpha- 5 beta -1 integrin/fibronectin and myosin II-dependent cell motility, is potentially organized by non-canonical Wnts/PCP, and is supported by a concomitant reduction in cadherins through localized Wnt/beta -catenin signaling. These studies …