Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"alpha lipoic acid"”.
-
Characterisation of Anti-Apoptotic Signalling Pathways in Hepatocytes activated by alpha-Lipoic Acid and Atrial Natriuretic Peptide
Both, the R-enantiomer of the antioxidant alpha-lipoic acid (R-LA) and the hormone atrial natriuretic peptide (ANP) are known to exert potent hepatoprotective action. The present work characterises alpha-lipoic acid- and ANP-mediated signal transduction pathways involved in the regulation of …
-
Selenotrisulfide Derivative Of Alpha-lipoic Acid: Evaluation In A Cell Culture Model For Potential Use As A Topical Antioxidant
… to covalent modifications of lipids, nucleic acids, and proteins within a cell. This damage has been implicated in the development of cancer and degenerative diseases. As the skin is the first level of defense for UV radiation, skin cancer is an obvious concern. Previous studies have …
-
Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells.
… the expression of hypoxia-inducible factor-alpha (HIF-1alpha). In an animal model of diabetes, HIF-1alpha protein expression was seen to increase in the vasculature surrounding the sciatic nerve at ten- and twenty-four weeks of diabetes duration, which was seen to be reversed at twenty-four …
-
Wirkung der Enantiomere der alpha- Liponsäure auf die Widerstandsfähigkeit von Erythrozytenkonzentraten auf oxidativen Stress bei Kryokonservierung
In der vorliegenden Arbeit stellte sich die Frage, ob die bewährte Methode der Kryokonservierung von Erythrozytenkonzentraten in Kombination mit einer Beimpfung mit der als Antioxidans ebenfalls bekannten a-Liponsäure (R-Enantiomer und Razemat) in einer wesentlichen Qualitätsverbesserung sowohl …
-
Investigating Potential Therapies to Decrease the Rate of Cystine Stone Growth in Slc3a1-/- Mice
… reabsorption of cystine and other dibasic amino acids. This leads to an accumulation of cystine in the urine, resulting in cystine stones. The SLC3A1/SLC7A9 cystine transporter accounts for 90% of cystine reabsorption and mutations in this transporter result in the formation of cystine stones. …
-
The Effects of Various Therapeutics on Cystine Stone Formation
… lab had shown that the nutritional-supplement α lipoic acid was an effective inhibitor of cystine stone formation. Here, we continued to further confirm the effects of α lipoic acid as an inhibitor and preventer of stone growth. Due to the unknown mechanism of α lipoic acid, we hypothesized α …