Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"allosterism"”.
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Ampa Receptor Allosterism: Measurement of The Conformational Changes In The Ligand Binding Domain of A Functional Receptor
Ionotropic glutamate receptors are important excitatory neurotransmitter receptors in the mammalian central nervous system that have been implicated in a number of neuropathologies such as epilepsy, ischemia, and amyotrophic lateral sclerosis. Glutamate binding to an extracellular ligand binding …
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Insight into G Protein-Coupled Receptors through Molecular Dynamics Simulations
… and class B of GPCRs. The results highlight that allosterism is a crucial event for the activation mechanism whether exerted by a molecule (such as AP8 for FFAR1) or by an accessory protein (such as RAMP for CTR).
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Ligand and Protein Dynamics of CYP3A4
… of promiscuity (binding and catalytic) and allosterism in CYP3A4 are ubiquitous but poorly understood. This work is dedicated to improving our understanding of the linkage between ligand binding and protein conformational dynamics with theoretical considerations of their impact on CYP3A4 …
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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
… effects are poorly characterized. To study allosterism of a ligand-receptor complex in a bilayer requires at least partial enrichment or isolation of the basic signaling unit. Many studies have employed biochemical purification and reconstitution strategies, but GPCRs are inherently unstable …
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Identification of Novel Allosteric Regulators of Human Erythrocyte Pyruvate Kinase
… that fitted a signloidal function indicative of allosterism. All the kinetic parameters of our enzyme were in excellent agreement with native R-PK activity as previously reported5, 57. R-PK activity in the presence of the analyzed compounds revealed both activators and inhibitors of R-PK. X-ray …
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An Investigation into the pharmacology of the ghrelin receptor
… Fitting data to a modified operational model of allosterism demonstrated that GHRP-6, L-692,585 and MK-677 were not ago-allosteric modulators of the GRLN-R but simple orthosteric agonists. In order to further examine the receptor-specific effects of ghrelin and the growth hormone secretagogues, a …