Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"allosteric coupling"”.
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Structure, function, and dynamics of cell motility proteins
… are predicted. The results indicate an allosteric coupling between the nucleotide pocket and the microtubule binding site of kinesin. The activation of two conformational switches at Gly234 and Ser202 triggers a cascade of structural changes in the motor domain. Our results suggest that …
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Cadherin specificity in adhesion and mechanotransduction
… of cadherins and exerts an inter-domain allosteric effect on multiple domains far away from EC1. The findings of the allosteric coupling between classic cadherin ectodomains reconcile several previous models of cadherin adhesion and may have important implications for the regulation of …
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Structural Studies of the Cold and Menthol Sensing Ion Channel TRPM8
… 4,5- bisphosphate (PIP2) as a cofactor, which allosterically couples with cooling agonists for channel activation. Since the cloning of trpm8 gene in 2002, substantial amount of functional studies has dedicated to understanding the molecular basis of ligand recognitions in TRPM8 and the …
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In Search of Generic Properties of Evolved Systems: From Elasticity of Proteins to Structure of Metabolic Networks
<p>In many proteins - especially allosteric proteins that couple regulatory state at allosteric sites to function at active sites - structural deformations are functionally important. To understand these deformations, dynamical experiments are ideal but challenging. Structural displacements can be …