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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"allopurinol"”.
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The Acute Effects of Allopurinol in Angina
… stress which increases myocardial demand. Allopurinol has been shown to prolong the time to ST depression on ETT, which is a marker of ischaemia. This may be via a number of mechanisms including effect on oxidative stress and endothelial stability.<br/><br/>This three arm cross over, double …
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The effect of allopurinol on left ventricular mass in haemodialysis patients
… Reduction of LVM may improve outcomes. Allopurinol has reduced LVM in randomised controlled trials in chronic kidney disease, diabetes and ischaemic heart disease. The aim of this thesis was to investigate whether allopurinol might also regress left ventricular mass indexed to body …
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Allopurinol Regresses Left Ventricular Hypertrophy in Patients with Type 2 Diabetes.
… (OS) has been implicated in LVH development. Allopurinol is a potent anti-oxidant, acting by blocking the enzyme Xanthine Oxidase, and has been previously shown to reduce vascular OS. Therefore the main aim of this thesis was to investigate whether allopurinol regresses LVH in patients with …
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Allopurinol as a possible oxygen sparing agent during exercise in peripheral arterial disease
… of needing amputation of one of their limbs. Allopurinol is a new possible treatment for this condition as it has been shown in coronary arterial disease to prolong exercise before angina pain occurs.<br/><br/>This is thought to be because allopurinol can both prevent oxygen wastage in tissues …
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Effect of allopurinol and hemin on some biological markers of aging in broiler chickens
… plasma uric acid concentrations using hemin and allopurinol and determine its effect on skin pentosidine, shear force value of Pectoralis major muscle, plasma glucose, body and breast weight, and chemiluminescence induced oxidative stress in broiler chickens. Allopurinol decreased plasma uric …
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The Effect of Allopurinol on Left Ventricular Mass in Patients with Treated Essential Hypertension
… is a major non-haemodynamic contributor to LVH. Allopurinol can act as a potent anti-oxidant by inhibiting xanthine oxidase generated reactive oxygen species and has been shown to improve vascular OS and reduce LVH in other conditions such as chronic kidney disease, diabetes mellitus and …
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The Efficacy of Allopurinol in Suppressing Hypersensitive-like Symptoms in Wheat (Triticum aestivum L.) and in Suppressing Sunflower Rust (Puccinia helianthi) Symptoms
… in hypersensitive reactions to fungal pathogens. Allopurinol can suppress ROS. Consequently, allopurinol was applied to a wheat lesion mutant to test the hypothesis that the same ROS are involved, regardless of the presence of the pathogen. ‘Ning7840’, a lesion mutant and ‘Alsen’, a related …
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Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease
… lung disease related pulmonary hypertension is allopurinol (a xanthine oxidase inhibitor) which decreases both uric acid and oxidative stress. We hypothesised that allopurinol could regress RVH in patients with pulmonary hypertension associated with chronic lung disease (PH-CLD).In a …
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The Effect of Allopurinol and Inosine Administration on Xanthine Oxidoreductase Gene Expression, Mitochondrial Respiration, and Inflammation in Broiler Chickens
… feed (INO) and Group 3, INO treatment plus 50 mg allopurinol/kg BM (INOAL). Allopurinol is a known inhibitor of XOR and thereby reduces uric acid (UA). INOAL birds showed lower total liver XOR activity (p=0.005) but kidney XOR activity was not affected. Both INO and INOAL birds had higher plasma …
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Renal and Blood Pressure Effects of Xanthine Oxidase Inhibitors in the FAST trial
… inhibitors. Data from the Febuxostat versus Allopurinol Streamlined (FAST) trial is presented in three studies:1) Up-Titration of Allopurinol in Patients with Gout. Patients recruited into the FAST trial have their sUA levels measured at the screening visit and patients with sUA >357 µmol/L …
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Factors Influencing Muscle Purine Nucleotide Metabolism.
… exercise. Study three examined the influence of allopurinol on urinary purine loss after repeated sprint exercise in humans. The final study examined the combined effects of allopurinol and sprint training on purine nucleotide metabolism in humans at rest.
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A study of the effectiveness of homoeopathically prepared dilutions of abscisic acid, molybdenum and allopurinol in inhibiting or promoting the germination of barley seeds (Hordeum vulgare)
Dissertation submitted in partial compliance with the requirements for a Masters Degree in Technology: Homoeopathy, Durban University of Technology, Durban, South Africa, 2008.
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The preparation and characterization of multi-component systems in drug pre-formulation
… The APIs under investigation included allopurinol (used for the treatment of gout and kidney stones), 6-thioguanine (used to treat acute myelogenous leukaemia) and valproic acid (for treatment of epilepsy and bipolar disorders). Allopurinol and 6-thioguanine were fairly intractable, …
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Prevention of stroke: risk stratification and targeted and novel therapies
… most apparent in females. A study of the use of allopurinol in those with diabetes showed that xanthine oxidase inhibition improves cerebral nitric oxide bioavailability suggesting a beneficial effect of allopurinol on cerebrovascular health. This study included 14 participants who had impaired …
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Biomarker analysis for APRT deficiency diagnosis using UPLC-MS/MS
… The disease can be treated with the drugs allopurinol and febuxostat, which prevent the conversion of adenine to DHA and thus reduce formation of kidney stones in APRT deficiency patients. UPLC-MS/MS method for simultaneous quantification of DHA, adenine and the drugs, allopurinol, …
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Development and use of a chemically defined medium for estimating the oxygen tolerance of campylobacter species
… tolerance of various Campylobacter species. Allopurinol, azelaic acid, caffeine, cimetidine, and pyruvate when used singly were the most effective in enhancing oxygen tolerance. When ROI scavengers were combined with dimethyl sulfoxide, the effects of allopurinol, azelaic acid, caffeine, …
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Purine Degradation and Ureide Catabolism by Soybean (Glycine Max (L.) Merrill); Cell Suspension Cultures
… of purine degradation, allantoxanamide and allopurinol, caused accumulation of uric acid and hypoxanthine, respectively, in cell suspensions fed radiolabelled IMP and effectively blocked growth on IMP, but not allantoin, as a sole nitrogen source.
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Defined Dimensional Changes in Purine Analogues
Pyrazolo{4,3-g}quinazolin-5-one (lin-benzoallopurinol), an extended analogue of 4-hydroxypyrazolo{3,4-d}pyrimidine (allopurinol), and pyrazolo{3,4-f}quinazolin-9-one (proxbenzoisoallopurinol), an extended analogue of 7-hydroxypyrazolo{4,3-d}pyrimidine (isoallopurinol), have been synthesized. The …
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Modeling Uric Acid Kidney Stones Disease in D. melanogaster using RNAi and Dietary Modulation
… stones in humans using our model. We found that allopurinol and potassium citrate reduced uric acid kidney stone formation in our model. We then tested whether compounds predicted to reduce uric acid and uric acid kidney stones in humans, but not currently used as treatments, can reduce uric acid …
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Effects of Febuxostat on Autistic Behaviors and Computational Investigations of Diffusion and Pharmacokinetics
… been shown to be more selective and potent than allopurinol in patients with gout. The first study developed a computational model to calculate an effective diffusion constant (Deff) of lipophilic compounds, such as febuxostat, that can cross endothelial cells of the blood-brain barrier (BBB) by …
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