Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"allopeptide"”.
-
Modulation of the T cell response with MHC class I peptides and their analogues
… strain combination. Secondly, the immunodominant allopeptide was selected to generate analogues in order to investigate their modulatory capacity. All peptides were tested in vitro in a standard proliferation assay and in vivo using a heterotopic heart transplantation model. Our findings show that …
-
CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… and indirect (recognition of self-MHC restricted allopeptide) pathways make to allograft rejection remains incompletely understood. In this thesis, murine models of heterotopic cardiac transplantation have been utilised to analyse these pathways. The key findings of this work are as follows: 1) If …
-
How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… degree of specificity and sensitivity for the allopeptide, similar to how they recognized their cognate ligand. Allopeptide recognition was also shown to not merely reflect mimicry of the cognate peptide. The integral role of the peptide in alloreactivity was further confirmed by the ability to …