Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"allograft rejection"”.
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Humoral alloimmunity in cardiac allograft rejection
Although the short-term outcomes of solid allograft survival have improved substantially over the last few decades, there has been no significant improvement in long-term survival of solid allografts. This thesis presents the initial characterisation of alloantibody mediated rejection in a murine …
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Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… contributes to the 90% success rate of corneal allografts without the need for histocompatibility matching and use of systemic immunosuppressive therapy. However, when one or more parameters that contribute to immune privilege are broken, the cornel allograft becomes vulnerable to the immune …
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Endomyocardial biopsy diagnosis of acute cardiac allograft rejection
… that may be used to diagnose acute cardiac allograft rejection; (ii) to review the use of the bioptome in sampling the donor heart endomyocardium; (iii) to review the light microscopic and histological grading of acute cardiac rejection; (iv) to characterise the mononuclear populations in …
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… decline in function attributed to chronic rejection. It is evident that the alloimmune response remains incompletely characterised. Crucially, despite description several decades ago, the precise contribution that the direct (recognition of intact allogeneic MHC) and indirect (recognition …
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Cytokine Gene Expressions of Peripheral Blood Mononuclear Cells in Acute Renal Allograft Rejection
… advances in immunosuppressive drugs, renal allograft rejection remains the main crucial determinant of the long term graft function and outcome. To solve this problem, there have been many efforts to explore the participation of cytokines and related gene expression in allograft rejection. …
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Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection
… ACTIVATION AND DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION</p> <p>By</p> <p><strong>KRISTIAN L. BROWN</strong></p> <p>2010</p> <p>Advisor: Gregory Auner, PhD</p> <p>Major: Biomedical Engineering</p> <p>Degree: Doctor of Philosophy</p> <p>Despite the advances made in the area of kidney …
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Role of Allergic Conjunctivitis in Inducing Corneal Transplant Rejection
Corneal allografts are the most commonly transplanted solid organs in humans and have a success rate of over 90%. This low incidence of graft rejection is largely due to the unique properties of the eye that decrease the likelihood of mounting an immune response, a phenomenon called "immune …
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Modulation of the T cell response with MHC class I peptides and their analogues
… plays a key role in initiating and sustaining allograft rejection. To prevent the risk of rejection, patients are given immunosuppressive drugs, which are non-specific and have major side-effects (infections, malignancies). It has been shown that the alloreactive T cells specifically recognize …
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IL-2-Dependent Regulation of Immune Homeostasis and Response to Infection
… treatment of autoimmune disease and preventing allograft rejection, and our findings help inform therapeutic manipulation and design for optimal patient outcomes. Treg cells play an essential role in return to homeostasis and maintenance of immunologic tolerance after response to infection, and …
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THE HCMV INTERACTOME: A QUANTITATIVE ANALYSIS OF HUMAN CYTOMEGALOVIRUS-HOST PROTEIN INTERACTIONS
… however it is among the most common causes of allograft rejection, and can lead to several life-threatening diseases in the immunocompromised. Moreover, it is the leading viral infectious cause for congenital disease. HCMV encodes 171 canonical genes, and a substantial number of non-canonical …
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Unsupervised Multi-Scale Analysis for the Identification of Placental Subtypes of Human Preeclampsia and Fetal Growth Restriction
… and histological lesions affiliated with allograft rejection, such as massive perivillous fibrin deposition. In the largest microarray dataset (N=330), two additional clusters were discovered. Cluster 4 samples were preterm controls with histological chorioamnionitis, while cluster 5 was …
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The spectrum of HIV-related kidney disease in South Africa
… identified on kidney biopsy. 8 4. Based on 179 allograft biopsies from 50 recipients, we report a high cumulative incidence of rejection episodes, with 36% showing T-cell-mediated rejection or antibody-mediated rejection (ABMR). Non-rejection findings included fibrosis, pyelonephritis, and …
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Role of IL-17A and Acaid in the Maintenance of Corneal Immune Privilege
… allows first time recipients of corneal allografts to enjoy a 90% success rate in the absence of systemic immunosuppressive drugs and without prior tissue typing. The myriad of immunoregulatory components that conspire to maintain the immune privilege of the cornea can be assigned to one …
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Modulatory role of IL-17 in airway inflammation
… conditions, such as chronic lung allograft rejection and acute respiratory distress syndrome.
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high-throughput techniques
… effects in the case of the former and acute allograft rejection in the latter. Hence there is an urgent need for more effective therapeutic strategies. In this study, we have evaluated the efficacy of two such potential therapeutic drugs, namely Rapamycin (rapa) and Genistein (GEN) and have …
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Einfluß des HMG-CoA-Reduktase-Inhibitors Atorvastatin auf die chronische Transplantatniereninsuffizienz der Ratte
Tierexperimentelle Untersuchung bezüglich chronische Transplantatnephropathie beziehungsweise deren fragliche Verminderung durch Gabe des Hydroxy-Methylglutharyl-Coenzym-A-Inhibitors Atorvastatin nach Nierentransplantation bei Ratten(Fisher344/Lewis); Vergleich von drei Versuchsgruppen-jeweils acht …
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Immunbiologie der Transplantatabstoßung : Untersuchungen zur antigenspezifischen T-Zell-Aktivierung in An- und Abwesenheit antigenpräsentierender Zellen
Nach der Übertragung MHC-differenter Organtransplantate sind die Transplantatempfänger auf eine lebenslange Immunsuppression angewiesen, um die Zerstörung des fremden Organs zu verhindern. Da hierzu jedoch das gesamte Immunsystem supprimiert wird, sind solche Patienten einem erhöhten Risiko …