Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"allergic response"”.
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The effect of degradation on the efficacy and utility of the biopharmaceutical enzyme Erwinia Chrysanthemi L-Asparaginase
… postulated as playing a role in immune-mediated allergic reactions during clinical administration of protein biopharmaceuticals such as L-asparaginases. Statistical analyses of allergic response during clinical use of ErA were compared to the lot-to-lot quantification of sub-visible protein …
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Modeling steric effects in antibody aggregation using rule-based methods
The allergic response is produced by the release of immune mediators by mast cells and basophils. This process, in turn, is initiated by the aggregation of antigens and IgE-FcεRI antibody-receptor complexes. Computational modeling of antibody- antigen aggregate formation as well as the size and …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… trigeminal sinonasal neurons in the context of allergic disease remain largely unexplored and unclear. This study investigated the impact of intranasal administration of house dust mite or fungal allergens on these cells and sought to understand the mechanisms underpinning the allergic response. …
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QSAR study of immunotoxicity in antibiotics.
… of a B-lactam's potential to induce an allergic response and to determine if a relationship between these responses and the molecular properties of the ~-lactams was present. In this study a database pertaining to frequency by which 70 p-lactams induce adverse reactions has been compiled …
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The effect of helical carbon nanotubes on macrophage function
… are proinflammatory and can exacerbate the allergic response. However, CNTs may also be immunosuppressive, both locally and systemically. Studies examining the relationship of airborne particulate exposure prior to pulmonary infection have reached different conclusions. In some cases, …
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Etude du rôle des macrophages interstitiels dans l'allergie des voies respiratoires
… endotoxin exposure in early life protect against allergic sensitization, most evidence indicates that exposure to house-dust endotoxin is a significant risk factor for increased asthma prevalence and severity. When the respiratory tract is stimulated with airborne endotoxins, lung dendritic cells …
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Trichuris Muris Whey Acidic Protein Induces Type 2 Protective Immunity Against Whipworm
… generate a strong T helper type 2 (TH2) immune response when delivered as subcutaneous immunization formulated with Montanide ISA 720. Oral challenge with <em>T. muris</em> infective eggs following vaccination led to a significant reduction in worm burden of 48% by r<em>Tm</em>-WAP49 and 33% by …
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Allergen-induced change in airway responsiveness to direct and indirect stimuli in mild atopic asthmatics
… increase following exposure to allergen but the response to mannitol an indirect stimuli, is not known. Furthermore, the provocative concentration causing a 20% decrease in Forced Expiratory Volume in one second (FEV1) for adenosine 5’ monophosphate (AMP) correlates better to sputum eosinophilia …
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Calcium Signaling Dynamics in RBL Cells Under Pulsed Ligand Exposure
… When coupled with fluorescence microscopy the responses of single cells loaded in the device can be measured using fluorescent reporters. In Aim 2, we have measured with high temporal resolution the calcium response of mast cells exposed to stimulus. Cells labeled with the calcium indicator …
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Mass spectrometry-based investigations to characterize specific cell types within the brain
… and mast cells, which are involved in allergic response. Moreover, morphologically similar cells can exhibit chemical heterogeneity; to characterize these differences, single-cell analyses are necessary. In this case, single cells from the model organism, Aplysia californica, are …
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Influence of chemical and mechanical stress on precision-cut lung slices
… the use of PCLS from sheep to study the response of airways and vessels to mediators. According to in vivo experiments sheep are thought to represent the human pathophysiology better than rodents. We therefore established the use of sheep PCLS and showed that methacholine, serotonin and …
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An exploration of raising a child in New Zealand with severe allergies and the potential for an anaphylactic reaction
… are increasing, as is the severity of the allergic response (Allergy New Zealand, 2012b; Lauritzen, 2004). Some research suggests a sevenfold increase in allergy diagnosis within the past ten years however as both severe and mild allergic responses are often misdiagnosed it is difficult to …
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New Mediators and Novel Mechanisms in Allergic Airway Inflammation
… are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by affecting the airway smooth muscle …