Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 39 for “"allergic disease"”.
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Improving the management of allergic disease in adults.
… at baseline characteristics in demographics, allergic background and immunological biomarkers. Chapter 6 describes the progress of participants who were enrolled into the OPAL study and completed their Week 24 study visits. These participants have become tolerant of at least 300mg of peanut …
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The role of human CD23 in lgE homeostasis & allergic disease
… mIgM, to upregulate IgE synthesis and provoke allergic responses.<br/>To test this hypothesis, purified tonsil B cells were stimulated with IL-4 and anti-CD40 to induce class switching to IgE in vitro. mCD23 was up-regulated and sCD23 accumulated in the medium prior to IgE synthesis. IL-10 and …
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Relationship between family histories and allergic disease with childhood atopic Dermatitis
… the relationship between parent's history of allergic disease and children's atopic dermatitis. Data from the 2011 Research on the Current Status of Atopic Disease with Elementary Schools and Kindergartens in Suwon were used for analysis. Among 20,052 persons agreeing to the survey 18,943 …
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Modulation of Allergic Disease through the use of Th1-associated Vaccine Adjuvants
<p>The prevalence of allergic disease such as peanut (PN) allergy has increased within the last century. Environmental factors have been associated with an increased risk of developing allergic diseases. The severity of allergic diseases has also increased and clinical trials are investigating …
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Exposure to Phthalate Mixtures and Inner-City Pediatric Allergic Disease and Airway Inflammation
… phthalates will have associations with adverse allergic and respiratory health outcomes in children. We tested this hypothesis in five self-contained manuscripts that characterize sources of exposure to phthalates in early life, demonstrate the application of new statistical methods for …
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… This finding was further confirmed in another disease model, namely the mouse asthma model. Mice overexpressing CD23 displayed suppressed allergic lung inflammation and reduced levels of IgE and Th2 cytokines and chemokines. Overall, the data provide a direct demonstration for CD23's role in …
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Correlation between pro-inflammatory alleles and clinical and laboratory markers of allergy in Xhosa South Africans
Background: Asthma and allergic disease are the result of a complex interaction between genetic predisposition and environmental exposure. It is likely that multiple genes are involved in the progression from allergen exposure to the development of signs and symptoms of allergic disease. Although …
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Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E
… triggers many cellular processes that drive allergic disease. While the role of IgE in mediating allergic responses is best described on basophils and mast cells, expression of the high-affinity IgE receptor on other innate immune cells, including monocytes, suggests that it may impact the …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… trigeminal sinonasal neurons in the context of allergic disease remain largely unexplored and unclear. This study investigated the impact of intranasal administration of house dust mite or fungal allergens on these cells and sought to understand the mechanisms underpinning the allergic response. …
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Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha
… Anisakis pegreffii induces gastrointestinal disease and allergy when ingested by humans, and can cause occupational allergy in seafood processing workers. The present study examines immune and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on …
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The Voice of the Patient
Allergic diseases, which constitute a global health problem, have been defined as one of the epidemics of the twenty-first century. Since there are no cures for allergic diseases today, the goal of treatment is to get the disease under control so that the patient can live a normal life with optimal …
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Peptide immunotherapy in models of allergic airways disease
… T cells are implicated in the pathogenesis of allergic disease. Peptide immunotherapy (PIT) involves therapeutic administration of short immunodominant peptides from within the protein allergen to which CD4+ T cell responses are directed. This approach can induce tolerance of allergen-reactive …
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Post-Translational Modification of Proteins via Ambient Air Pollutants and Endogenous Reactive Species
… and may have implications in the increase in allergic disease seen worldwide. The reaction of proteins with ozone and nitrogen dioxide has been previously studied in controlled laboratory studies, but not extensively in urban air. In Chapter 3 we develop and characterize a method for the …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
… cleavage would be beneficial to the control of allergic disease by stabilizing CD23 at the cell surface. Inhibitor studies performed by our group as well as others indicate that the enzyme responsible for CD23 ectodomain shedding is a hydroxamate-sensitive metalloproteinase. Through …
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Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
… dermatitis (cAD) is a chronic inflammatory skin disease affecting up to 10% of the canine population, it is the second most common allergic disease in dogs. Canine AD has many similarities to human AD and for this reason the dog has been suggested to be a good animal model to study AD in people. …
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Adaptation of Three Different Apoptotic Methods in Equine Bronchoalveolar Cells and Comparison of Bronchoalveolar Lavage Cell Apoptosis in Normal and COPD Affected Horses Before and After Dexamethasone Administration
… regulate pulmonary inflammation. Equine COPD, an allergic disease of the lower airway, is likely due to dysregulation of the pulmonary immune response. In this study, the hypothesis tested was COPD affected horses would have less apoptotic airway lymphocytes than control horses during clinical …
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Molecular characterisation of parvalbumin and analysis of cross-reactivity in five fish species using sera from fish-allergic consumers and occupationally exposed workers
… accounts for over 95% of clinical symptoms in allergic fish consumers. Importantly, this allergen displays lgE cross-reactivity thus allergic sufferers can exhibit clinical symptoms after the ingestion of non-sesitising fish species. In an occupational setting, fish products have also been …
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Effects of n-3 LCPUFA supplementation for pregnant and lactating women in preventing allergic diseases in early childhood
… immune pathways involved in the development of allergic diseases in early childhood, potentially leading to a reduction of allergic diseases in children. Thus the focus of this thesis was to determine whether maternal n-3 LCPUFA supplementation during pregnancy or lactation could prevent …
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The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium
… a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that characterize asthma. Current models suggest that TSLP is produced by epithelial cells in response to inflammatory stimuli and acts upon hematopoietic …
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
… that IFN-α/β is a candidate for the treatment of allergic disease.
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