Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"allelic exclusion"”.
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The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion
… in-frame protein, a mechanism known as allelic exclusion prevents further recombination.</p><p>The nucleosome can positively and negatively regulate V(D)J recombination. Therefore, we defined the in vivo nucleosome organization of accessible and inaccessible RSSs on the Tcr loci. We used …
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Vβ Recombination Signal Sequences Mediate Monoallelic And Monogenic Tcrβ Gene Assembly: Implications For The Tcrβ Repertoire And Allelic Exclusion In Health And Disease
Monoallelic expression of antigen receptor (AgR) genes is assumed to be critical for the proper development and function of T and B lymphocytes. AgR loci are composed of variable (V), joining (J), and sometimes diversity (D) gene segments that must be cleaved and assembled by RAG-endonuclease …
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Transcription, Editing, and Switching of Antibody Genes
… that secondary gene recombination, as well as allelic exclusion of light chain genes is under transcriptional regulation.</p>
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… of dual TCR T cells. This occurs from incomplete allelic exclusion of the TCRα loci during thymic development, allowing for simultaneous rearrangement of TCRα on both alleles until positively selecting signals are received through the TCR. In dual TCR T cells, only one TCR needs to …