Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 811 for “"alleles"”.
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Recombinant b alleles of Ustilago maydis
… system governed by an estimated 25 alleles at the b locus. Haploid strains must have different b alleles in order to be sexually compatible and pathogenic. Existing sequence data from several b alleles show a variable domain in the first 110 codons and a constant domain through the …
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Characterization of novel genetic alleles of cellulose synthase
Cellulose is the most abundant polymer on earth. Despite this, relatively little is known about the proteins and biochemical mechanisms governing cellulose biosynthesis. Only in the past 10 years since the sequencing of the Arabidopsis thaliana genome have we begun to unravel the full complexity of …
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Heterosis as Evidence of Yield Alleles from Wild Soybean.
North Carolina State University Theses Crop Science, Soil Science.
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Lethal alleles in wild population of Mus musculus (house mice)
The primary objectives of this investigation were to sample a wild population of Mus Musculus in Virginia and to report on the nature of the genetic material located at a specific point on the ninth chromosomal linkage group in this species.
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Common Alleles of the SLAM/CD2 Family are Associated with Murine Lupus
… cluster forms two stable, linked haplotypes of alleles in 33 common inbred laboratory strains of mice. The B6-like haplotype is found only in a small set of C57-strains, while the B6.Sle1b-like haplotype is found in all of the remaining, including the autoimmune-prone MRL, NOD, and NZB, as well …
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Identifying Dominant Alleles for Disease Resistance and Stalk Quality in Inbred Maize
… (donor lines) containing dominant favorable alleles not contained in the parents of an F1 cross, was evaluated using both hypothetical and field data. The relative number of the loci containing dominant alleles in each donor line not present in the F1 is described by the statistic …
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Polymerase chain reaction-based genotyping of swine MHC DQB and DRB alleles
… chain reaction (RT-PCR) method. Five SLA DQB alleles and three SLA DRB alleles were sequenced after oligonucleotide-directed amplification of mRNA. Sequence alignment studies of SLA DQB and DRB $\beta\sb1$ domain sequences provided a similarity index among seven SLA DQB alleles of 87%, and the …
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Conditional Protein Alleles and Regulation of Bacterial Transcription: A Thesis in Two Acts
… to generate small molecule sensitive protein alleles without the need to screen for a new drug. In the first, which we term conditional protein splicing (CPS), an intein is split into two inactive fragments which are activated by heterodimerization. By fragmenting the target protein and fusing …
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A functional study of the<em> Phytophthora infestans</em> Avr3a alleles and paralogs
… all P. infestans isolates studied contain Avr3a alleles E80M103 and/or K80I103. However, a study of Avr3a diversity in the Toluca Valley, Mexico, has identified additional alleles such as K80I103L139, K80I103H133, E80M103H133 and E80M103G124. Functional studies of these alleles were conducted as …
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The role of heterozygous lysosomal storage disorder alleles as risk factors for dementia
Alzheimer’s disease, the most common form of dementia, is characterised by extracellular amyloid beta plaques and intraneuronal tau tangles. While it is not fully understood why these pathological hallmarks develop, several biological systems are believed to be involved. Of these, lysosomal network …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
Natural killer: NK) cells are innate immune lymphocytes that react to cells lacking self-MHC: major histocompatibility complex) class I molecules, such as transformed or virally infected host cells and allogeneic bone marrow. This reactivity is mediated by inhibitory receptors for MHC class I that …
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Identification of Deleterious and Disease Alleles in a General Population and Preterm Labor Patients
… new methods to predict disease-causing alleles in a personal genome by integrating functional evidences from sequence conservation, genome-wide association studies and the transcriptional regulatory network. However, even in protein-coding regions, it is not well understood how often and …
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Identification of low-penetrance alleles, genetic modifiers and mutation analysis in familial breast cancer cases
To date, germline mutations in known high-penetrance genes, mainly <i>BRCA1</i> and <i>BRCA2</i>, and in moderate- and low-penetrance genes are responsible for approximately 30- 35% of breast cancer familial clustering, leaving the majority of them unexplained. In addition, the variability of the …
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Using spontaneous haploid genome doubling to access favorable alleles in exotic maize (Zea mays L.) germplasm
… purging mutational load of deleterious recessive alleles. Accounting for all the improvements of DH production over the years, genome duplication is still a major bottleneck. Its efficiency tends to be reduced when the technology is applied in exotic germplasm. The use of spontaneous haploid …
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Genetic Characterisation of Human ABO Blood Group Variants with a Focus on Subgroups and Hybrid Alleles
… was to compare the molecular diversity of ABO alleles with various phenotypes, and to contribute to our knowledge of the ABO gene and encoded glycosyltransferases. Novel alleles (six Aweak, eleven Bweak, seven O) were identified containing single-point mutations. Structure/function studies …
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Quantitative Trait Loci, and Use of the Theory for Detecting Favorable Alleles in Maize Genetic Materials
Most of the tropical populations had favorable alleles for the diseases evaluated. When comparing populations crossed to elite inbreds for adaptation reasons, use of the same elite background is important. Four populations were found which were in the top ranked populations for relative number of …
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Comparison of the molecular phenotypes of pigs carrying different IGF2 alleles at four developmental time points
A single nucleotide polymorphism in insulin-like growth factor 2 (IGF2 intron3-G3072A) is associated with greater muscle mass and decreased subcutaneous fat deposition in pigs carrying a paternal copy of the A allele (Apat). While many studies have focused on the differences in between the gross …
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Correlation between pro-inflammatory alleles and clinical and laboratory markers of allergy in Xhosa South Africans
… of the prevalence of potential pro-inflammatory alleles (PIAs), as well as to investigate the relationship between these PIAs and clinical and laboratory markers of asthma and allergic disease. Results: We found several significant associations between several SNPs and allergic disease, …
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Generation of genetically modified mice with conditional alleles of Dyrk1a : a minimal animal model of Down syndrome
Down Syndrom (Trisomie 21) ist die Hauptursache für geistige Behinderung. Die “Down Syndrom kritische Region“ auf dem menschlichen Chromosom 21 ist ausschlaggebend für die Trisomie 21-assoziierte geistige Behinderung und für die Monosomie 21-assoziierte Mikrocephalie. Unter den bisher ungefähr zwei …
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