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Showing 1 to 16 of 16 for “"alkaloid biosynthesis"”.
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Understanding and manipulating alkaloid biosynthesis
Humans have exploited plant alkaloids as medicines since at least the Neolithic Era. Today, alkaloids such as vinblastine (isolated from Catharanthus roseus) and morphine (isolated from Papaver somniferum) are prescribed to treat various cancers and relieve pain, respectively. Despite this storied …
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Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?
The occurrence of certain alkaloids in the human brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This protein, termed BSCv, may catalyze alkaloid formation in humans. If such …
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Substrate analogs to investigate alkaloid biosynthesis in Catharanthus roseus
Terpene indole alkaloids are a class of natural products produced by plants, many of which are used clinically for the treatment of human disease. Natural products, are not produced by the organism for the purpose of treating human disease and often tailoring of the natural product scaffold results …
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Reprogramming alkaloid biosynthesis in Catharanthus roseus : synthetic biology in plants
… roseus) produces over 130 monoterpene indole alkaloid (MIA) natural products. Many of these compounds have pharmaceutical value, such as the anticancer agents vinblastine and vincristine. Unnatural modifications can impart novel bioactivity to the parent natural product. Advances in synthetic …
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Nature's approach toward ring formation and structural diversity in ergot alkaloid biosynthesis
Ergot alkaloids are fungal-derived secondary metabolites well known for a diverse array of pharmacological effects both beneficial and detrimental to human health. Historically, the ergot alkaloids have been known to cause ergotism in populations that consume grain contaminated by ergot alkaloid …
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Exploiting alkaloid biosynthesis in Madagascar periwinkle to obtain natural product derivatives and new biocatalysts
Plant alkaloid biosynthesis produces many natural products with medicinal value. For example, vinblastine and vincristine from Catharanthus roseus monoterpene indole alkaloid biosynthesis, and camptothecin derivatives from Ophiorrhiza pumila quinoline alkaloid biosynthesis, are anticancer agents …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… 130 structurally complex monoterpene indole alkaloids are produced, including the clinically used anti-mitotic drugs, vinblastine and vincristine. The common intermediate to all monoterpene indole alkaloids is strictosidine, the product of an asymmetric Pictet- Spengler condensation of …
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Characterization of the A/B regulon in tobacco (Nicotiana tabacum)
Plant alkaloids are secondary metabolites that may be synthesized in an inducible defense response to herbivory (Baldwin 1999). Genetic engineering of secondary metabolic pathways in plants to enhance or reduce metabolite production is limited by the current understanding of these pathways and …
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Identification and characterization of an adenosine triphosphate binding cassette (ABC) transporter EcABCB1 involved in the transport of alkaloids in Eschscholzia californica
… and functionally diverse benzylisoquinoline alkaloids, notably the antimicrobial sanguinarine in the cell and the media. In E. californica cell suspension cultures, alkaloid biosynthesis is induced by treatment with certain biotic and abiotic elicitors, which activates plant defense …
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Crystallization studies of Pictet-Spenglerases
… important molecules. Monoterpene indole alkaloids from plants are an especially important source of therapeutic molecules. Due to the complexity of these molecules, biosynthesis of derivatives is an attractive way of obtaining molecules with potentially new or improved functionality. The …
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From Forest Floors to Pharmacology: Elucidating Millipede Defensive Alkaloids for Drug Discovery
… possess repugnatorial glands, which store alkaloids as defensive compounds. However, they have also evolved unique characteristics that set them apart from all other millipedes, including distinct anatomy, group behavior, brood care, and the production of terpenoid alkaloids. Prior to 2020, …
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TROPANE ALKALOID PRODUCTION BY DATURA
… of the rate limiting step(s) in the biosynthesis of the alkaloids followed by manipulation of the plant cell's genome so as to induce constitutive overproducers of alkaloids. Of particular importance to the project was the development of reliable methods for the detection and …
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Investigations into the molecular evolution of plant terpene, alkaloid, and urushiol biosynthetic enzymes
… families involved in either nicotine/tropane alkaloid biosynthesis (putrescine N-methyltransferase) or primary metabolism (spermidine synthase) by attempting to interconvert a spermidine synthase to encode putrescine N-methyltransferase activity based upon past patterns of natural selection. …
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Studies into the Biosynthesis and Chemical Synthesis of Indolocarbazoles and Related Heterocyclic Compounds. Metalation of Indole-6-Carboxamide.
… RebC, an enzyme that plays a pivotal role in the biosynthesis of the indolocarbazole alkaloid rebeccamycin. A homologous enzyme, StaC, exists in the biosynthetic pathway for staurosporine, a related indolocarbazole. Structural differences between the RebC and StaC active sites were hypothesized to …