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Showing 1 to 20 of 225 for “"alkaloid"”.
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Alkaloid syntheis via novel azabicycles.
… introduction to pyrrolizidine and indolizidine alkaloids has been described along with a selection of recent syntheses of the said compounds.Cycloalkene synthesis by intramolecular Wittig reaction has been reviewed and we describe the utility of this strategy in the formation of …
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TROPANE ALKALOID PRODUCTION BY DATURA
… rate limiting step(s) in the biosynthesis of the alkaloids followed by manipulation of the plant cell's genome so as to induce constitutive overproducers of alkaloids. Of particular importance to the project was the development of reliable methods for the detection and quantification of the …
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Understanding and manipulating alkaloid biosynthesis
Humans have exploited plant alkaloids as medicines since at least the Neolithic Era. Today, alkaloids such as vinblastine (isolated from Catharanthus roseus) and morphine (isolated from Papaver somniferum) are prescribed to treat various cancers and relieve pain, respectively. Despite this storied …
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Chemical Investigations in Complex Alkaloid Synthesis
… to further biochemical investigations. Complex alkaloids have been of interest to synthetic chemists for decades where their intriguing chemical structures have led to the development of new reactions as well as provided biologically relevant compounds for potential therapeutic use. The growing …
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Chiral alkaloid derivatives: Synthesis and medicinal chemistry applications
The preparation of a selection of novel opioid alkaloids based on alteration at the 1, 3 and 6 positions of codeine and morphine has been achieved. Herein we present the synthetic methodology, structural characterisation and biological evaluation of these novel opioid species. A range of opioid …
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Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?
The occurrence of certain alkaloids in the human brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This protein, termed BSCv, may catalyze alkaloid formation in humans. If such …
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Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine
… work is to study novel compounds based on the alkaloids present in Mitragynina speciosa (Korth), a tree indigenous to Southeast Asia. Consumption of leave extracts of this plant have been linked to the attenuation of the withdrawal syndrome associate with opioid dependence. Taking into …
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Asymmetric Total Synthesis of the Pentacyclic Indole Alkaloid (+)-Tacamonine
… class of pentacyclic monoterpenoid indole alkaloids. Its close structural similarity to the potent cerebral vasodilator (-)-vincamone has promoted several efforts towards its synthesis, culminating in the appearance of two asymmetric and seven racemic syntheses in the literature. This …
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Substrate analogs to investigate alkaloid biosynthesis in Catharanthus roseus
Terpene indole alkaloids are a class of natural products produced by plants, many of which are used clinically for the treatment of human disease. Natural products, are not produced by the organism for the purpose of treating human disease and often tailoring of the natural product scaffold results …
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Bioinspired Structural Revision of the Marine Flatworm-Derived Alkaloid Pseudocerosine
… the synthetic efforts towards marine-derived alkaloid pseudocerosine (36). Isolated as a deep blue pigment from the marine flatworm Pseudoceros indicus, this natural product was reported to contain a unique heteroaromatic scaffold comprising an azafulvene-embedded azepinoindole and an …
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Studies on the Alkaloid Slaframine and Synthesis of Model Aminoindolizidines
Made available in DSpace on 2014-12-09T17:36:46Z (GMT). No. of bitstreams: 1 7020966.pdf: 5645903 bytes, checksum: 253924cef872cf1fda9f956efb5312cd (MD5) Previous issue date: 1970
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Reprogramming alkaloid biosynthesis in Catharanthus roseus : synthetic biology in plants
… roseus) produces over 130 monoterpene indole alkaloid (MIA) natural products. Many of these compounds have pharmaceutical value, such as the anticancer agents vinblastine and vincristine. Unnatural modifications can impart novel bioactivity to the parent natural product. Advances in synthetic …
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Expanding the Role of Oxidoreductases in Benzylisoquinoline Alkaloid Metabolism in Opium Poppy
Benzylisoquinoline alkaloids (BIAs) are a large and structurally diverse group of plant specialized metabolites with several possessing pharmacological properties including the analgesic morphine, the cough suppressant codeine, and the vasodilator papaverine. In opium poppy, the antepenultimate and …
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Localization of monoterpenoid indole alkaloid (MIA) biosynthesis by in situ hybridization (ISH)
Monoterpenoid indole alkaloids (MIA) are among the largest and most complex group of nitrogen containing secondary metabolites that are characteristic of the Apocynaceae plant family including the most notable Catharanthus roseus. These compounds have demonstrated activity as successful drugs for …
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Functional Characterization of Monoterpenoid Indole Alkaloid (MIA) Biosynthetic Genes in Catharanthus roseus
The monoterpenoid indole alkaloids (MIAs) of Madagascar periwinkle (Catharanthus roseus) are known to be among the most important source of natural drugs used in various cancer chemotherapies. MIAs are derived by combining the iridoid secologanin with tryptamine to form the central precursor …
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Part One: Stereospecific Synthesis of Trisubstituted Olefins. Part Two: Cephalotaxus Alkaloid Esters
Made available in DSpace on 2014-12-13T20:09:48Z (GMT). No. of bitstreams: 1 7606999.pdf: 4588533 bytes, checksum: b276a6c9ec0d3ea23da6f850f28f72e2 (MD5) Previous issue date: 1975
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