Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"alisertib"”.
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Preclinical Evaluation of Immunomodulatory Effects of Aurora Kinase Inhibition In Human Papillomavirus Positive Cancers
… investigation focused on the effectiveness of alisertib, an Aurora Kinase A inhibitor using preclinical mouse tumor models of HPV+ cancers (mEER, TC-1, and C3.43). In vitro, alisertib treatment when compared to the vehicle control, reduced the level of phospho-Aurora Kinase A confirming the …
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Modulation of the aquaporin-2 localization in renal principal cells
… inhibitors, aurora-A inhibitor I and alisertib, inhibited the cAMP-dependent AQP2 redistribution in two cell models by effects on the actin cytoskeleton. Novel derivatives of aurora-A inhibitor I provided insights into the structure–activity–relationship (SAR) of the inhibitor. …
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FANCD2 in relation to BRCA2 mutated breast cancer
… PARP inhibition treatment tolerance with alisertib Aurora-A inhibition that could work against FANCD2 activation in cells lacking BRCA2 expression. Statistical significance was found for high FANCD2 nuclear expression and low age at diagnosis, larger tumor sizes, tumor grade and increased …
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Cellular Determinants Of AURKA Degradation By Small Molecule Proteolysis-Targeting Chimeras
… the emergence of resistance mechanisms. MLN8237 (alisertib) is an example of a high-affinity, selective kinase inhibitor of AURKA which has mostly failed in clinical trials. More recently, kinase-independent functions of AURKA (e.g., oncogenic signalling, transcriptional activation) have been …