Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"alg2"”.
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Congenital Disorder of Glycosylation (CDG) - Ih
… activity of the human ortholog of the yeast ALG2 mannosyltransferase which catalyses the transfer of mannose residues onto Man1GlcNAc2-PP-dolichyl at the cytosolic site of the endoplasmic reticulum in the early onset of glycoprotein biosynthesis. The patient presented normal at birth but …
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Investigating the pathway of asparagine-linked glycoprotein biosynthesis
… of two mannosyltransferases in the pathway, Alg2 and Algl 1, remained ambiguous. This thesis describes the biochemical studies that were carried out to clarify these roles. The substrate specificity of Algl, the first mannosyltransferase in the pathway, was studied, and this enzyme was also …