Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"aldosterone"”.
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A functional study on novel genes involved in regulating aldosterone secretion in normal human zona glomerulosa and in aldosterone-producing adenomas
… about 10%. About half of PA cases are caused by aldosterone-producing adenomas (APA). Two APA subtypes, ZG-like and ZF-like APAs, have been described, according to the histological resemblance to normal zona glomerulosa (ZG) and zona fasciculata (ZF), underlying somatic mutations (KCNJ5 commonly …
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Dietary Electrolytes and their Influences on Plasma Aldosterone Concentration
… and potassium excretion, and plasma levels of aldosterone, a mineralocorticoid hormone that has been linked to incidence hypertension, in a cohort of healthy children and young adults. We found that higher plasma aldosterone level was associated with lower sodium excretion in the urine, in …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… factors, including the mineralocorticoid hormone aldosterone, are implicated in its pathogenesis. Aldosterone antagonism reduces cardiovascular morbidity and mortality in patients with advanced chronic HF and survivors of large AMI who develop HF and/or are diabetic. These benefits could, at least …
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Mechanism of Aldosterone Regulation of Sodium Transport in A6 Epithelia
The mineralocorticoid hormone, aldosterone, is known to stimulate Na$\sp+$ transport in tight epithelia. The goal of this dissertation was to study the mechanism of aldosterone stimulation of Na$\sp+$ transport through amiloride-sensitive Na' channels (ENaCs) in cell cultured A6 epithelia. …
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Role of serotonin in the regulation of aldosterone secretion from the rat adrenal gland
… the effect of the indoleamine serotonin on aldosterone secretion from the adrenal gland. To date numerous studies have reported this steroidogenic effect, describing the second messenger system utilised and in some species the receptor type involved. However the full physiological and …
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Studies of aldosterone renin ratio and genetic variation at the CYP11B1/CYP11B2 locus in human essential hypertension
… In humans, mutations in the genes encoding aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1), responsible for the final stages of aldosterone and cortisol production respectively, lead to rare monogenic disorders. Both, glucocorticoid remediable aldosteronism and 11β-hydroxylase …
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Adrenal response to chronic and acute water stress in Japanese quail, Coturnix coturnix japonica
Adrenal corticosterone and aldosterone content, body weight changes and serum osmolality were examined during water restriction and water deprivation. Progressive water deprivation resulted in increased serum osmolality and decreased body weight; adrenal aldosterone content did not change. Adrenal …
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Human aldosterone synthase and 11[beta]-hydroxylase: studies on the relationship of structure and function and their clinical implications
… Mutations have been identified which destroy aldosterone synthase 18-hydroxylase activity or 18-oxidase activity or both, resulting in lack of aldosterone. Structure-function studies have identified aldosterone synthase residues specifically involved in 18-hydroxylation and 18-OHDOC production …
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Effects of Stress, Circadian Rhythms, and Dietary Sodium on Brain Cell-Nuclear Uptake of Aldosterone and Corticosterone (Steroid Receptors)
The binding of the adrenal steroid hormones aldosterone (ALD) and corticosterone (CORT) in brain cell-nuclei has been implicated as a necessary step in the behavioral and physiological actions of these hormones. In vivo uptake of radioactively labeled ALD and CORT in adrenalectomized (ADX) rats …
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Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenal.
… the major causes of PA is sporadic formation of aldosterone-producing adenomas (APAs). These benign tumours develop in the cortical region of adrenal glands and autonomously secrete excessive amounts of aldosterone. This hormone increases sodium retention and water reabsorption by the kidneys, …
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Effects of Low and High Sodium Chloride Diets and Furosemide Administration on Cardiac Function, Plasma Electrolyte Concentrations, and the Renin-Angiotensin-Aldosterone System
… concentrations, and the renin-angiotensin-aldosterone system, in healthy canines. Twenty mixed-breed canines were allotted to one of four groups, Group I - Dogs fed low sodium diet (0.08% sodium), Group II - Dogs fed high sodium diet (1.0% sodium), Group III - Dogs fed low sodium (0.08%) …
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Regulation of Sodium Transport in A6 Epithelia by Prostaglandin E(2)
… investigated in both unstimulated (n = 11) and aldosterone-stimulated states of Na + transport (n = 8) where changes of transport measured as amiloride-sensitive short-circuit currents (INa) could be decomposed into the underlying time-dependent changes of iNa, Po and NT. After a short delay of …
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The Effects of Vasoactive Intestinal Peptide on Adrenal Steroid Hormone Secretion
… responsiveness was assessed by measuring aldosterone and corticosterone release following stimulation with the physiological secretagogues ACTH and angiotensin II. ACTH (10$\sp{-12}$ to 10$\sp{-8}$ M) stimulated dose-dependent increases in aldosterone secretion (1.9 to 36.9 fold over basal …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
… system (KKS), endothelin (ET) and aldosterone have important implications in the regulation of salt homeostasis. To precisely characterize the relations between the KKS, ET and aldosterone male BN and BNK rats were given standard or high salt diet in presence or absence of …
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AN EXPANSION ON DIAGNOSTIC AND PROGNOSTIC MARKERS IN DOGS WITH ACUTE AND CHRONIC HEART FAILURE
… The first study evaluated the urinary aldosterone-to-creatinine ratio (UAldo:C), a potential indicator of patient’s overall renin-angiotensin-aldosterone system (RAAS) activity, in healthy dogs and dogs with naturally occurring myxomatous mitral valve disease (MMVD) and investigated the …
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The kidney in diabetes mellitus : urinary transfer in excretion, hypertension, the Renin-Angiotensin-Aldosterone system, and the role of angiotensin converting enzyme inhibitors in therapy
Patients with diabetic renal disease develop elevated urinary albumin excretion rates [AER] and hypertension. Preliminary data from several groups suggest that diabetic patients handle transferrin, a protein similar in size and weight, in a different fashion from albumin. In the first part of this …
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The cardiovascular profile of the low renin phenotype in a black South African population
… particularly the role of the renin-angiotensin-aldosterone system (RAAS). The RAAS is the master regulator of water, electrolyte and blood pressure balance. The rate-limiting enzyme of this cascade, namely renin, is usually suppressed in Africans and as a result low-renin hypertension is common …
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
… water retention by stimulating the release of aldosterone. ACE inhibitors, such as captopril, enalapril and lisinopril, are highly effective in the treatment of hypertension and congestive cardiac failure. Previous studies have suggested that angiotensin converting enzyme (ACE) production may …
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
… renal principal cell MR, which is activated by aldosterone, in ENaC-mediated sodium reabsorption. For this purpose, mice deficient for MR in ENaC-expressing renal principal cells were generated using the Cre-loxP recombination system. A large fragment of genomic mouse DNA harbouring 156 kb of …
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