Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"aldehyde dehydrogenase"”.
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A small molecule-guided structure-function exploration of mitochondrial aldehyde dehydrogenase
… the observed enhancement of human small aldehyde metabolism by kudzu flowers. First, we selected mitochondrial aldehyde dehydrogenase 2 (ALDH2) as a representative enzyme for small aldehyde metabolism. We subsequently identify one kudzu flower-derived isoflavone, kakkalide, that is able …
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Expression of Aldehyde dehydrogenase (ALDH) in the breast stem cell line D492 and relations to stem cell properties
Aldehyde dehydrogenases (ALDH) are enzymes expressed in both normal and cancer stem cells (CSC). CSCs are hypothesized to arise from normal stem cells and acquire a malignant phenotype through series of genetic mutations. Current therapies often fail to eradicate CSCs causing metastatic relapse. …
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Characterization of the meta-cleavage pathway enzymes, 4-Hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating), from Pseudomonas sp. strain CF600
… thesis focuses on three aspects of the aldolase-dehydrogenase. First, DmpG was overexpressed and purified in order to address the question of whether this polypeptide alone possesses 4-hydroxy-2-ketovalerate aldolase activity. While previous work had indicated that DmpF alone can catalyze …
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Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
… were discovered. These two compounds compete for aldehyde binding, which was vali-dated both by kinetic and crystallographic studies. Structure activity relationship dataset has helped us determine the basis of potency and selectivity of these compounds towards ALDH3A1 activity. Our data is …
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Determining the Roles of the Aldehyde Dehydrogenase Enzymes 5 and 6 during Icewine and Table Wine Fermentation in a Commercial Wine Yeast Using CRISPR-Cas9.
… reduce NAD(P)+ to NAD(P)H via NAD(P)+-dependent aldehyde dehydrogenase proteins (Aldp). Previous research linked the NAD+ redox imbalance during Icewine fermentation with ALD gene expression patterns indicating a role of Ald3p encoded by ALD3 in elevating the acetic acid whereas in table wine, …
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Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… have been described and measurement of high aldehyde dehydrogenase (ALDH) activity has been defined as a characteristic of stem cells (SCs). In this study, a library of novel small molecules (1,4-di-substituted acetalanthraquinones, AAQs), containing an acetal group as protected aldehyde …
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Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… have been described and measurement of high aldehyde dehydrogenase (ALDH) activity has been defined as a characteristic of stem cells (SCs). In this study, a library of novel small molecules (1,4-di-substituted acetalanthraquinones, AAQs), containing an acetal group as protected aldehyde …
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Explorative studies to understand if aldehyde dehydrogenase (ALDH) expression in colon cancer can be exploited as a target for therapeutic intervention. Expression profiling of ALDH7A1 in colorectal cancer
… to treat with current treatment options. Aldehyde dehydrogenases (ALDHs) are enzymes that play key roles in protecting cells against aldehyde-generated toxicity. Specific isoforms are also known to contribute to disease development. Emerging evidence suggests that specific ALDH isoforms …
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The characterization of Clostridium beijerinckii NRRL B592 cells transformed with plasmids containing the butanol-production genes under the control of constitutive promoters
… than is the case with the wild-type cells. The aldehyde dehydrogenase from C. beijerinckii NRRL B593 (ald) and alcohol dehydrogenase from C. beijerinckii NRRL B592 (adhA) were placed under the control of the promoter from the acid-producing operon (the BCS operon) in one vector, and under the …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.
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Targeting Aldehyde Dehydrogenases in NF2-null Meningioma and Schwannoma
… caused by NF2 loss, drives overexpression of aldehyde dehydrogenase 1A1 (ALDH1A1) in NF2-null schwannoma. High expression of ALDH1A1, and the related isoform ALDH1A3 have been identified as markers of cancer stem cell activity and have been correlated with poor prognosis and chemoresistance in …
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… stem/progenitor cells (HSPC) isolated by high aldehyde dehydrogenase activity (ALDHhi) reduce hyperglycemia after transplantation into streptozotocin (STZ)-treated NOD/SCID mice. However, UCB-derived ALDHhi cells are rare and expansion without the loss of regenerative function is required. We …
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Cytometry of Reaction Rate Constant (Crrc): Optimization of the Technique and Development of a Novel Protocol to Assess Cell Population Heterogeneity Based on Aldh1a1 Activity in Vitro
… develop a protocol for in vitro CRRC studies of aldehyde dehydrogenase 1A1 (ALDH1A1)-based cell heterogeneity. The data collected suggested a potential positive correlation between the activity of ALDH1A1 and the age of a cell line. Finally, I demonstrated the robustness of the new CRRC ALDH1A1 …
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… Additionally, OS stem-like cells display high aldehyde dehydrogenase activity and sarcosphere formation under limited nutrient media and anchorage independence. These markers are not feasible targets for therapy due to their expression on normal tissue stem cells; however, upstream regulators …
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Investigation of Carbamathione Pharmacokinetics and Pharmacodynamics by In Vivo Microdialysis and Capillary Electrophoresis
… for alcoholism is its inhibition of liver aldehyde dehydrogenase (ALDH2). Recent studies have reported that disulfiram exhibited an anti-craving effect with both alcohol addiction and cocaine dependence. Inhibition of ALDH2 cannot explain disulfiram's efficacy in cocaine dependence. The …
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Genetic and Biochemical Analysis of Phosphinothricin Tripeptide Biosynthesis in Streptomyces Viridochromogenes
… biosynthesis is the reduction of phosphonoacetaldehyde to hydroxyethylphosphonate by PhpC, an alcohol dehydrogenase with a previously unrecognized role in PTT biosynthesis. We also demonstrated that step IV of PTT biosynthesis is the conversion of hydroxyethylphosphonate to …
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