Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"alcohol dehydrogenase"”.
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Transcription regulation of the class II alcohol dehydrogenase 7 (ADH7)
The class IV alcohol dehydrogenase (ADH7, µ-ADH, σ-ADH) efficiently metabolizes ethanol and retinol. ADH7 is expressed mainly in the upper gastrointestinal tract with no expression in the liver unlike the other ADHs, and is implicated in various diseases including alcoholism, cancer and fetal …
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Purification, identification and characterization of "atypical" human liver alcohol dehydrogenase isoenzymes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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A novel diazonium-sulfhydryl reaction in the inactivation of yeast alcohol dehydrogenase by diazotized 3-aminopyridine adenine dinucleotide
… enzyme during the complete inactivation of yeast alcohol dehydrogenase. The reaction of sulfhydryl groups was indicated by titration studies with 5,5'- dithiobis (2-nitrobenzoic acid) as well as isolation and quantification of the cysteinyl derivative released by acid hydrolysis of the modified …
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The characterization of Clostridium beijerinckii NRRL B592 cells transformed with plasmids containing the butanol-production genes under the control of constitutive promoters
… the case with the wild-type cells. The aldehyde dehydrogenase from C. beijerinckii NRRL B593 (ald) and alcohol dehydrogenase from C. beijerinckii NRRL B592 (adhA) were placed under the control of the promoter from the acid-producing operon (the BCS operon) in one vector, and under the control of …
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Genetic and Biochemical Analysis of Phosphinothricin Tripeptide Biosynthesis in Streptomyces Viridochromogenes
… to hydroxyethylphosphonate by PhpC, an alcohol dehydrogenase with a previously unrecognized role in PTT biosynthesis. We also demonstrated that step IV of PTT biosynthesis is the conversion of hydroxyethylphosphonate to hydroxymethylphosphonate in a chemically novel reaction catalyzed by …
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The Stereochemistry and Mechanism of The Biosynthesis of Ent-Sandaracopimaradiene and Related Diterpenes
… of geranyl-geranial-1-d with horse liver alcohol dehydrogenase and NAD('+) with ethanol as a proton source. Inspection of the vinyl region of the ('1)H NMR spectrum of sandaracopimaradiene biosynthesized from (S)-geranylgeranyl pyrophosphate-1-d indicated that the deuteriovinyl group had …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.
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Thelin Operon in Pseudomonas Incognita: Cloning, Nucleotide Sequence and Deduced Amino Acid Sequence of Cytochrome P-450lin and Other Enzymes Involved in the Catabolism of Linalool
… (4) regulatory, (5) linalool-8-aldehyde dehydrogenase, (6) linalool-8-alcohol dehydrogenase, (7) lin-redoxin and (8) lin-redoxin reductase. The identities of the P-450lin, lin-redoxin, lin-redoxin reductase and linalool-8-alcohol dehydrogenase were also confirmed by the presence of the …
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Pushing the limits of aldoxime dehydratases for the synthesis of industrial relevant nitriles and their use in chemo- and biocatalytic cascade reactions
… towards dialdehydes was the oxidation of dialcohols with an Anelli-type TEMPO-oxidation. For this green and mild oxidation method a solvent screening was performed, showing that nitriles are suitable solvents for this reaction type and a variety of different primary and secondary alcohols …
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Prozessentwicklung mit maßgeschneiderten rekombinanten Biokatalysatoren zur Synthese einer Bulk- und einer Feinchemikalie
… double oxidation of cyclohexanol by means of an alcohol dehydrogenase and a cyclohexanone monooxygenase towards ε-caprolactone without isolation of the intermediate cyclohexanone, inhibition of the monooxygenase especially by the product was addressed by solvent engineering. However, increase of …
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Nano-structured platinum-based catalysts for the complete oxidation of ethylene glycol and glycerol
Direct alcohol fuel cells are a viable alternative to the traditional hydrogen PEM fuel cell. Fuel versatility, integration with existing distribution networks, and increased safety when handling these fuels increases their appeal for portable power applications. In order to maximize their utility, …
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A Systematic Method for Enhanced Expression of Alcohol Dehydrogenases in Escherichia coli
… of catalytically active protein. Commercial alcohol dehydrogenases are enzymes often produced in recombinant systems that are primarily employed in industrial chemical catalysis; the formation of inclusion bodies currently limits product yield of these enzymes. The primary aim of the work …
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THE ECOLOGICAL IMPORTANCE AND EVOLUTIONARY POTENTIAL OF PHENOTYPIC PLASTICITY IN NOVEL ENVIRONMENTS
… in phenotypic plasticity in a functional trait, alcohol dehydrogenase, and its effect on larval survival of Drosophila melanogaster in a novel alcohol environment. After a population colonizes a novel environment, the population often adapts to this new environment, and phenotypic plasticity has …
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The Cloning of a Putative Regulatory Gene and the sol Region from Clostridium beijerinckii
… the adh gene which encodes a primary/secondary alcohol dehydrogenase in isopropanol-producing clostridia suggests that the stc gene may be functionally related to isopropanol production. From C. beijerinckii NRRL B592, a region which encompassed the solvent-production genes ald (aldehyde …
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Mechanistic investigations of enzymes in phosphonate metabolism
… Additionally, this thesis presents a study on an alcohol dehydrogenase that reduces phosphonoacetaldehyde (PnAA) to 2-HEP; the implications for the biosynthetic pathway for fosfomycin are discussed. Finally, observations made while studying an aldehyde dehydrogenase that oxidizes PnAA to …
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Enzymology of butanol formation in Clostridium Beijerinckii
… increase simultaneously. CoA-acylating aldehyde dehydrogenase (ALDH) was purified to near homogeneity. The ALDH showed a native M.. of 100,000, and a subunit Mr of 55,000. ALDH could use either NAD(H) or NADP(H) as the coenzyme. ALDH was oxygenlabile. The O₂-inactivated enzyme could be …
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Structural and Functional Microbial Ecology of Denitrifying Bacteria Using Different Organic Carbon Sources
… 4) examine the potential of using alcohol dehydrogenase gene as a biomarker for methanol and glycerol induced denitrification activity; 5) evaluate the impact of different carbon sources (methanol and ethanol) on the transcript and proteome of a model facultative methylotroph, …
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Acqua: solvente elettivo in Organocatalisi e Biocatalisi
… the use of an enzyme belonging to the class of alcohol dehydrogenase, the Horse Liver Alcohol Dehydrogenase (HLADH) which was selected and used in the enantioselective reduction of aldehydes to enantiopure arylpropylic alcohols. This enzyme has showed an excellent responsiveness to this type of …
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