Global ETD Search
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Showing 1 to 8 of 8 for “"akirin"”.
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Investigation of Akirin Nuclear Localization and the Molecular Interaction between Akirin and Taf4 in Drosophila
<p>Akirin is a highly conserved protein that has been linked to myogenesis, cardiomyogenisis, and innate immunity. This investigation focused on Akirin in two different aspects, developmentally and subcellularly. Developmentally, we focused on further characterization of Akirin’s role in embryonic …
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Akirin-Mediated Gene Regulation During Cardiac Development
<p>The highly conserved nuclear protein Akirin<em> </em>was previously identified as a cofactor that modulates Twist transcription factor activity during muscle development in <em>Drosophila melanogaster</em>. Akirin mediates an interaction between the Twist transcription factor and the …
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Colocalization between Akirin, the NuRD Complex, and Histone Modifications
<p>Akirin is a small highly conserved nuclear protein that has been of scientific interest since its discovery in 2008. Akirin functions as a transcriptional co-factor for many important biological pathways; however, detail regarding Akirin’s mechanism remains unclear. Of the 4 major animal …
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Investigation into the Akirin Subcellular Localization and Developmental Interactions
<p>Akirin is a highly conserved nuclear protein ubiquitously expressed in nonfungal eukaryotic species and is known to be involved in many biological processes such as embryonic muscle patterning and innate immune function. Akirin functionality is essential for the prevention of disease and …
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Interaction of akirin and pannier during embryogenesis of Drosophila melanogaster
<p><em>Akirin</em>, a highly conserved protein found in nearly all eukaryote species, is a transcriptional cofactor that has been known to play a critical role in the muscular development in <em>Drosophila</em>. In this study, we identified and analyzed the genetic interaction of <em>akirin …
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Investigating the molecular function of Akirin during skeletal myogenesis in Drosophila melanogaster
… of the <em>Drosophila </em>larval musculature. Akirin, a highly conserved nuclear protein, appears to play a critical role in the regulation of Twist-dependent gene expression during mesodermal specification and muscle development. Specifically, Akirin serves as a cofactor to promote …
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Analysis of the Role of Akirin Interactions with Nuclear Body Proteins During Myogenesis
<p>Akirin is a highly conserved, small nuclear protein of indeterminate structure ubiquitously expressed in non-fungal eukaryotic species. It was first discovered in the innate immune response, but many other functions have since been found, including embryonic muscle patterning and myogenesis. …
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Novel use of a cell-penetrating peptide-adaptor system to characterize Akirin constructs and investigate activity of bacterial effector proteins
… of calcium. TAT-CaM can be used to characterize Akirin constructs and investigate the activity of bacterial effectors, AopP and AvrA, in the NF-kB pathway. Akirin is a small nuclear protein that was shown to interact with transcription factor Twist and chromatin remodeler Brahma. The functional …