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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"airway smooth muscle"”.
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Dynamic equilibration of airway smooth muscle length during physiological loading
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.
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Investigations into the molecular regulation of gene expression in airway smooth muscle cells
The phenotype of airway smooth muscle (ASM) differs in asthmatic patients compared to healthy individuals. Hyperplasia, hypertrophy, increased contraction and altered synthetic capabilities of asthmatic airway smooth muscle cells (ASMCs) have all been reported, however, the molecular mechanisms …
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The Anti-Inflammatory Effects of Low Concentrations of Carbon Monoxide in Human Airway Smooth Muscle Cells
… asthma. Similar studies implicate human airway smooth muscle cells (HASMC) as contributing to CO’s anti-inflammatory effects by inhibiting the release of pro-inflammatory cytokines including granulocyte macrophage colony stimulating factor (GM-CSF). However, the mechanism related to the …
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Neurally Released Nitric Oxide does not Oppose Reflex Cholinergic Contraction of Airway Smooth Muscle in Dogs
When afferent nerve endings in the airway detect a foreign substance, centrally mediated reflexes, acting through cholinergic parasympathetic efferents, contract airway smooth muscle. It has been proposed that these efferents also release nitric oxide, which relaxes airway smooth muscle, and that …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… of inflammation, vasodilation, and relaxation of smooth muscle. Airway smooth muscle cells (HASMC) are involved in multiple aspects of chronic inflammatory airway diseases such as asthma and COPD, including airflow restriction and release of pro-inflammatory mediators. While the response of HASMC …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… of inflammation, vasodilation, and relaxation of smooth muscle. Airway smooth muscle cells (HASMC) are involved in multiple aspects of chronic inflammatory airway diseases such as asthma and COPD, including airflow restriction and release of pro-inflammatory mediators. While the response of HASMC …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… of the disease pathology including; airway remodelling, airways hyperreactivity and airways inflammation. The interaction of mast cells and human airway smooth muscle (HASM) cells play an important role in the characteristic pathological processes involved with asthma. The recently …
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Perturbed equilibria of myosin binding in airway smooth muscle and its implications in airway hyperresponsiveness and asthma
In asthma, the key effector driving acute airway narrowing is thought to be airway smooth muscle (ASM); as the muscle surrounding the airways shortens, the airway lumen narrows. Airway hyperresponsiveness (AHR) - the excessive narrowing of the airways - is one of the cardinal features of asthma. …
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Factors influencing the responsiveness of human bronchi
The primary function of airway smooth muscle is to contract, regulating the airway tone and bronchial narrowing. Research extending over a number of decades has identified many of the major factors contributing to the degree of bronchial contraction at a cellular level including receptor mediated …
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Local Control of Blood Flow in the Bronchial Circulation of Dogs
… supplies nutritive flow to the conducting airways.I studied the local control of blood flow in the bronchial circulation of dogs. The three aims of my study of the bronchial circulation were to determine: 1) distribution of blood flow from the right bronchial artery: 2) the role of …
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New Mediators and Novel Mechanisms in Allergic Airway Inflammation
… involved in the allergic response can induce airway hyperreactivity by affecting the airway smooth muscle directly and to identify novel mediators involved in allergic airway inflammation. The effect of the pro-inflammatory cytokine interleukin (IL)-4 on airway smooth muscle contractions was …
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A Combined In Vivo and In Vitro Approach to the Study of Endotoxemia in Swine
… also observed in central venous pressure and airway pressure. Transient increases, followed by decreases, were observed in mean systemic arterial pressures and systemic vascular resistance. Decreases were seen in cardiac output, cardiac index, arterial partial pressure of oxygen and oxygen …
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Efeito relaxante de derivados N-sulfonilidrazônicos do rolipram em traqueia de cobaia : investigação do mecanismo de ação do LASSBio-1846
… of new drugs to treat the symptoms of airway diseases were synthesized new PDE4 inhibitors from rolipram. The new N - sulfonilhidrazone derivatives had been only tested on in vitro enzymatic assa ys. To investigate their effects on physiological conditions, the guinea - pig trachea …
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The role of anaphylatoxins in asthma and airway remodelling
… location of complement components in asthmatic airways. -- Experiments described in this thesis demonstrate the expression and localisation of certain complement components and their two receptors in the bronchial mucosa. C3a and C5a-stimulated production of remodelling mediators and the …
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Extracellular matrix stiffness and geometry: The impact on static and dynamic cellular systems in vitro and the treatment of tissue ischemia
… stiffness (Chapter 2). Next, the function of airway smooth muscle cells is investigated on substrates with physiological and pathological stiffnesses as it pertains to the cell adhesion, proliferation, calcium signaling and secretory function (Chapter 3). And finally, the impact of inner …
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Response of Peripheral Blood Lymphocytes from RAO-affected Horses to b2-Agonist Stimulation
Recurrent airway obstruction (RAO) affects middle-age horses, inducing bronchoconstriction and airway inflammation. β2-agonists like salbutamol are used as treatment, promoting airway smooth muscle (ASM) relaxation and bronchodilation. In addition to ASM, inflammatory cells express the …
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Rapid Rac GTP-ASE activation in live cells by mechanical stress is independent of Src
… local mechanical stresses to living human airway smooth muscle cells with a magnetic bead bound to the cell surface via transmembrane adhesion molecule integrins. The temporal and spatial activation of Rac, a small guanosine triphosphatase, was quantified using a fluorescent resonance …
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Characterization of the airway epithelial bioelectric mechanisms associated with the effects of epithelium-derived relaxing factor in guinea pig-isolated trachea
… which subsequently diffuses to the underlying airway smooth muscle to initiate relaxation. Hypertonicity-induced smooth muscle relaxation via EpDRF involves epithelial Na+ and Cl- channels and is preceded by a depolarization of the transepithelial potential difference (Vms). By utilizing two …
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Study of cellular mechanisms of inflammation and the involvement of mast cells in disease
… the critical interactions between mast cells and airway smooth muscle in asthma (Chapter 4) as well as neuropeptide-induced mast cell degranulation to characterize mast cell function in neurogenic inflammation (Chapter 5). Collectively, this work presents CFMA as a promising technique for the …
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