Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 98 for “"airway inflammation"”.
-
Nitric oxide in airway inflammation
… (EBC) is a non-invasive method of investigating airway inflammation associated with nitric oxide (NO) and the metabolites nitrite/nitrates (NOx) in diseases such as chronic obstructive pulmonary disease (COPD), but some of the variables affecting the results are unknown. It was hypothesised that …
-
Exhaled nitric oxide in asthmatic airway inflammation
… (eNO) in the breath is a new method to monitor airway inflammation in asthma and may have a role in the management of asthma. The hypotheses were that eNO will reflect the degree of inflammation in chronic asthma, and will indicate how anti- inflammatory therapy should be altered to improve …
-
Role of Toll-like receptors in airway inflammation
… TLRs in different cell types involved in upper airway inflammation, with special emphasis on recurrent tonsillar infection and allergic rhinitis. We also sought to map cellular and molecular changes occurring as a result of allergen-specific immunotherapy. In the first two studies, a distinct …
-
New Mediators and Novel Mechanisms in Allergic Airway Inflammation
Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by …
-
Non-invasive method of measuring airway inflammation : exhaled nitric oxide
… NO was therefore a key molecule in modulating inflammation, including airway inflammation. The aim of this thesis was: 1. To adapt a NO chemiluminscence analyser from measuring airway pollution to measuring exhaled air in human subjects. 2. To measure NO levels in exhaled air in adult subjects. …
-
Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered …
-
<i>Haemophilus influenzae</i> modulins in chronic obstructive pulmonary disease airway inflammation
<p>Nontypeable <em>H. influenzae</em> (NTHi) causes repeated respiratory infections characterized by a brisk inflammatory response that results in the expression and secretion of proinflammatory cytokines. We hypothesized that secreted and cell asssociated NTHi proteins mediate cellular …
-
TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
Asthma is a chronic disorder of the conducting airways that involves the interplay of multiple genetic and environmental factors. It is characterized by reversible airway obstruction, cellular infiltration, airway inflammation and airway remodeling. Dendritic cells (DCs) are professional antigen …
-
Effect of atorvastatin on asthma control and airway inflammation: a randomised controlled trial
… preliminary data obtained in models of pulmonary inflammation suggest that the effects manifest in rheumatoid patients can be achieved also in asthma. A proof of concept study was designed to test the hypothesis that atorvastatin improves asthma control and airway inflammation in adults with …
-
Exposure to Phthalate Mixtures and Inner-City Pediatric Allergic Disease and Airway Inflammation
… early life exposure to phthalates and eczema and airway inflammation in children. Participants were enrolled from the longitudinal birth cohort of the Columbia Center for Children's Environmental Health (CCCEH) in New York City. Phthalate metabolites were measured in prenatal and child urine …
-
Airway inflammation, diagnosis, perception of asthma, and sputum zinc levels in a community cohort.
… (IS), an established research tool to measure airway inflammation (AI), is normally confined to specialised institutions and selected populations with airway disease, especially asthma. This thesis examines the role of IS in the diagnosis of asthma in a community. The first study explores the …
-
Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… asthma, a chronic inflammatory disease of the airways, show pathological changes in the airways, including airway remodeling, basement membrane thickening, and epithelial damage with large immune cell infiltrate. How the epithelium contributes to airway remodeling and subepithelial fibrosis is …
-
THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… effects of CB2 agonists on allergic airway inflammation using a mouse model of asthma and resolve any mechanisms that underpin the immunosuppressive properties observed using in vitro assays. The murine model of allergic lung inflammation entailed transferring ovalbumin (OVA) specific …
-
THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… effects of CB2 agonists on allergic airway inflammation using a mouse model of asthma and resolve any mechanisms that underpin the immunosuppressive properties observed using in vitro assays. The murine model of allergic lung inflammation entailed transferring ovalbumin (OVA) specific …
-
The effect of Vitamin D status on lung function and airway inflammation in adults in Saudi Arabia and the UK
… effect of vitamin D status on lung function and airway inflammation is still debatable. This project aimed to investigate the effect of vitamin D intervention through pharmacological supplements or dietary intake, on lung function and airway inflammation, among asthmatic adults in Saudi Arabia …
-
The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… and OBJECTIVE: Leukotriene E4 contributes to airway inflammation by interacting with P2Y12 receptor as well as type 1 and 2 cysteinyl leukotriene receptors. We investigated the effects of P113, a P2Y12 receptor antagonist, on airway inflammation in a mouse model of allergic asthma. MATERIALS …
-
Soluble C-Kit Receptor Level May Be a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation
… and asthma are characterized by a Th2-dependent inflammation composing activated mast cells and eosinophils. Mast cell development and survival is dependent on the Kit-mediated activation and this stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether …
-
Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
… and/or episodic respiratory distress induced by airway hyperresponsiveness (AHR), airway eosinophilia, and airway remodeling. Homeostasis in the lung is partially maintained by the neuroimmune axis, where cross-talk between these systems is mediated via cytokines, neuropeptides and their …
Page 1 of 5