Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"airway hyperresponsiveness"”.
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Perturbed equilibria of myosin binding in airway smooth muscle and its implications in airway hyperresponsiveness and asthma
In asthma, the key effector driving acute airway narrowing is thought to be airway smooth muscle (ASM); as the muscle surrounding the airways shortens, the airway lumen narrows. Airway hyperresponsiveness (AHR) - the excessive narrowing of the airways - is one of the cardinal features of asthma. …
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The acute response to sprint interval exercise and moderate intensity continuous exercise in adults with and without airway hyperresponsiveness
… however, SIE has not been studied in adults with airway hyperresponsiveness (AHR). Methods: Eight adults with AHR and eight adults without AHR completed both SIE (4x30 second sprints at 7.5% body weight) and moderate intensity continuous exercise (MICE) (20 minutes at 65% peak power output). …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… and OBJECTIVE: Leukotriene E4 contributes to airway inflammation by interacting with P2Y12 receptor as well as type 1 and 2 cysteinyl leukotriene receptors. We investigated the effects of P113, a P2Y12 receptor antagonist, on airway inflammation in a mouse model of allergic asthma. MATERIALS …
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Existence of patchiness in constricted lungs : from experiments to complex system modeling
… and physicians pinpoint mechanisms that govern airway hyperresponsiveness and effectively treat complex respiratory diseases such as asthma. The advancement in this research field has been prompted by the usage of medical imaging technology and computational modeling providing a subjectspecific, …
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Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
… and/or episodic respiratory distress induced by airway hyperresponsiveness (AHR), airway eosinophilia, and airway remodeling. Homeostasis in the lung is partially maintained by the neuroimmune axis, where cross-talk between these systems is mediated via cytokines, neuropeptides and their …
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The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction
… bronchoconstriction (EIBC) occurs as a result of airway cooling and drying in adults with airway hyperresponsiveness (AHR). Continuous exercise leads to a significant decline in lung function; however, interval exercise may allow ventilation to recover and prevent EIBC. PURPOSE: To determine the …
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IL-10 Deficiency as a Factor in Airway Cellular Responses to Inhaled Sulfur Dioxide
… responses in response to SO2, 2) enhanced airway hyperresponsiveness to reactive oxygen species, and 3) deficient airway IL-10 production. This combination of factors may explain why asthmatics react with greater sensitivity to SO2 than non-asthmatics. A literature review was undertaken to …
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Vitamin D and Immunomodulation in Bronchial Asthma
… most common chronic inflammatory diseases of the airways. The chronic inflammation is associated with airway hyperresponsiveness (AHR), airway obstruction and airway remodeling. In asthmatics the airway epithelium produces increased amounts of proinflammatory cytokines including TNF-α (Tumour …
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Mold Induced Asthma: Not all Molds are Created Equal
… strains. C. cladosporioides induced robust airway hyperresponsiveness (AHR), eosinophilia, and a predominately Th2 response, while A. versicolor induced a strong Th17 response and neutrophilic inflammation, but very mild AHR. Neutralization of IL-17A resulted in strong AHR and eosinophilic …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
The airway epithelium establishes a boundary between the internal and the external environment that protects against potential injury and infection caused by inhaled particles, debris and microbial pathogens. In order to maintain the health of the lungs and surrounding tissues, the epithelium …
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Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… asthma, a chronic inflammatory disease of the airways, show pathological changes in the airways, including airway remodeling, basement membrane thickening, and epithelial damage with large immune cell infiltrate. How the epithelium contributes to airway remodeling and subepithelial fibrosis is …
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Development and Testing of Pharmacological Tools to Evaluate the Role of Protease-Activated Receptor-2 in Allergic Asthma
… and attenuates asthma symptom development (e.g. airway hyperresponsiveness, excessive mucus production, and inflammation) in a murine model of asthma. Use of in vitro studies enable the cell-specific examination of PAR2 contribution to A. alternata-induced airway inflammation. I show PAR2 …
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The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology
… including goblet cell hyperplasia and acute airway inflammation, depend on IL-4Rá signalling. A key feature of IL-4Rá signalling is the induction of a strong TH2 response which induces the development of alternatively activated macrophages (AAMs). AAMs are associated with tissue remodelling …
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Characterization of Biomedical and Incidental Nanoparticles in the Lungs and Their Effects on Health
… to a decrease in lung function parameters and airway hyperresponsiveness, indicating increased lung stiffness after long-term nanoparticle exposure. Our data adds significant contributions to the field by assessing two nanoparticles with vastly different compositions in the lungs. Overall, we …
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A guinea pig model of human respiratory syncytial virus lung infection
… asthma, a disorder characterized by reversible airway obstruction, airway hyperresponsiveness and airway inflammation. Because latent or persistent pulmonary viral infections have been implicated in the pathogenesis of the airway inflammation underlying asthma, a guinea pig model of human RSV …
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Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
Asthma is an inflammatory airway disease characterized by airway eosinophilia, airway obstruction due to an increased mucus production by goblet cells, airway remodeling, and airway hyperresponsiveness (AHR) to a variety of stimuli. In allergic airway inflammation, dendritic cells (DC) deliver …
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Influence of Obstructive Sleep Apnea (OSA) on Rostral Fluid Shift, and the Pathophysiology on Asthma
… of asthma, declined lung function, increased airway hyperresponsiveness, and greater need for asthma medications. Previous studies showed that overnight fluid shift from the legs into the neck and peripharyngeal tissues increases upper airway resistance and severity of OSA. Recent findings …
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Sensory-Mechanical Responses to High-Dose Methacholine Bronchoprovocation: The Modulating Effects of Deep Inspirations
… and methacholine (MCh)-induced cough with normal airway sensitivity (COUGH) are incompletely understood. Defining the range of normal responses associated with deep inspirations (DIs) during high-dose MCh is key to understand the clinical relevance of COUGH. Purpose: To characterize responses to …
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Vagal Integration of Cardiopulmonary Regulation
… (ANS) control in the development of murine airway hyperresponsiveness. Sensitization decreased HRV prior and subsequent to antigen challenge, suggesting that HRV reflects early changes in ANS function and may be useful in the detection of early lung disease. I also applied HRV analysis for …
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A mouse model of childhood asthma: mechanisms of development and progression following an early-life respiratory viral infection
… Development of an asthmatic phenotype (allergic airway inflammation, changes of remodelling and airway hyperresponsiveness (AHR)) required both recovery from neonatal infection and subsequent allergen sensitisation/challenge. By comparison, changes of remodelling were evident in mice that …
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