Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"airway epithelium"”.
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3D Nanoscale Architecture and Physiology of the Human Airway Epithelium
… is observed in the differentiation of airway basal stem cells into multiciliated cells within the human respiratory epithelium – a tissue barrier crucial for protection against bacteria, viruses, and particulate matter. In this thesis, I present the first isotropic three-dimensional map …
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The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium
The epithelially-derived cytokine thymic stromal lymphopoietin (TSLP) plays a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that characterize asthma. Current models suggest that TSLP is produced by …
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A mathematical model of the airway epithelium: Computational studies of ion and water balance
… time course of ion and water transport across airway epithelia. Model variables were intracellular and apical concentrations of sodium, potassium, chloride; apical, basolateral, and transepithelial membrane potentials; cell and apical volumes. Membrane transport processes included apical …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
The human airway epithelium represents the primary site of infection for many respiratory viruses, including influenza A virus (IAV). To safeguard this tissue and maintain the functionality of the lung, humans possess a two-layer, extracellular, mucus barrier composed predominantly of individual …
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Airway Epithelium Organotypic Culture Models as a Platform for Adverse Outcome Pathway Assessment of Engineered Nanomaterials
… a high-content in vitro model of the conducting airway to characterize Gà E effects, or in this case—the effects of genotype à phenotype interaction (Gà P), in order to identify determinants of sensitivity and help define both regulatory and mechanistic bases for these effects on AgNP toxicity. …
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Mechanisms of virus infection of human airway epithelium cultured at an air-liquid interface (HAE-ALI)
ABSTRACT Polarized human airway epithelial (HAE) cultures are instrumental for studying respiratory tract diseases and gene delivery of airways. Primary epithelial cells isolated from tracheobronchial airways, grown in transwell at an air-liquid interface (ALI), undergo media-induced mucociliary …
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Asthma: Cytokine-Induced Over-Expression of Matrix Metalloproteases Compromises Airway Epithelium Tight Junctions and a Clinical Case Study
… disease that results in a constriction of the airways. While there is no known cause of the disease, one possible theory of the molecular cause of asthma is that the tight junctions of the airway epithelium are disrupted as a result of cytokine activity that up regulates expression of matrix …
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Isolation of human amniotic stem cells from term placenta and their in vitro differentation in airway epithelium to correct CF phenotype
… of bone marrow stem cells to differentiate in airways epithelium is very low (0.01–0.025%), as also demonstrated by different studies in CF mice. Recently, new cell sources for CF treatment have been characterized; MSCs from cord blood and amniotic fluid stem cells can differentiate in vitro …
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The regulation and function of viperin during rhinovirus infection
The airway epithelium is the primary site of rhinovirus replication and plays a pivotal role in orchestrating innate immune responses to respiratory viruses, including rhinovirus. Interfacing with inhaled material in the airway lumen, the airway epithelium experiences continuous onslaught from …
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Stem and Progenitor Cells in Homeostatic Maintenance and Perturbation of the Pulmonary Epithelium
… progression from a normal pseudostratified airway epithelium to lung squamous cell carcinoma in situ are well documented. However, the contribution of mutated tissue stem or progenitor cells to this process are poorly understood at the level of clonal resolution. Secretory cells are known …
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Molecular Mechanisms of Airway Epithelial Progenitor Cell Maintenance and Repair.
<p>The lungs are vital organs whose airways are lined with a continuous layer of epithelial cells. Epithelial cells in the distal most part of the lung, the alveolar space, are specialized to facilitate gas exchange. Proximal to the alveoli is the airway epithelium, which provides an essential …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
The airway epithelium establishes a boundary between the internal and the external environment that protects against potential injury and infection caused by inhaled particles, debris and microbial pathogens. In order to maintain the health of the lungs and surrounding tissues, the epithelium …
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Vesicle-associated Membrane Proteins in Airway Mucin Secretion
… gene expression among all VAMP isoforms in human airway secretory cells, as revealed by an analysis of a public scRNA-seq database. Using airway epithelium specific deletant mice,</p> <p>I found that VAMP8 mediates both baseline and stimulated secretion. At the subcellular level, VAMP8 is …
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Investigating factors governing cell fate decisions in respiratory epithelium
The maintenance of the airway/respiratory epithelium during adult homeostasis and repair and its construction during embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are …
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Mechanotransduction via airway epithelial cells : the effect of compressive stress
… a change in the structural organization of the airway epithelium. This complex process known as airway remodeling is not fully understood, and we believe that the forces accompanying airway constriction activate the epithelium and contribute to airway remodeling. To better understand this …
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Regulation of airway epithelial cell migration by the cystic fibrosis transmembrane conductance regulator.
The airway epithelium is a critical barrier between the noxious particles in inspired air and the lung tissue. Mucociliary clearance is an essential function of the airway epithelium to protect against infection and airway damage. By this process, inhaled particles are trapped in the mucus lining …
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Characterization of Lung Inflammation Induced by Exposure to Fipronil
… the thickened alveolar septa, disruption of the airways epithelium and damage to vascular endothelium in the intranasal and the oral groups. Lung sections stained for von Willebrand factor showed that mice exposed to fipronil either orally or intranasally had increased staining in the endothelium …
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Exploring Ciliary Dynamics: Assessing Motility and Induced Velocity in Human Airway Cell Cultures
… terminal bronchioles is lined by a mucociliated epithelium. Here, cilia underpin an essential defence mechanism known as MCC. This process clears inhaled pathogens and contaminants from the airways and exhibits various degrees of complexity. Differently from the case of microorganisms, where …
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Investigating the impact of gold nanoparticles on pulmonary cells: From 2D to 3D culture systems
… impact of gold nanoparticle aerosols on human airway epithelium differentiation is discussed in Chapter 4. We show how to build a 3-dimentional human lung model cultured at an air-liquid interface. Gold nanosphere aerosols were delivered to the cocultures of primary human pulmonary cells …
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