Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"airway epithelial cells"”.
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Pathways for mechanotransduction in pressurized airway epithelial cells
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.
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Mechanotransduction via airway epithelial cells : the effect of compressive stress
… a change in the structural organization of the airway epithelium. This complex process known as airway remodeling is not fully understood, and we believe that the forces accompanying airway constriction activate the epithelium and contribute to airway remodeling. To better understand this …
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Ironing Out the Host-fungal Interaction in Airway Epithelial Cells
… is a ubiquitous fungus associated with several airway complications and diseases including asthma, allergies, cystic fibrosis, and most commonly invasive aspergillosis. The airway epithelium, a protective barrier, is the first anatomical site to interact with A. fumigatus. Although this …
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Nerve growth factor regulates Na+ transport in human airway epithelial cells
… between elevated NGF levels in the lung and airway diseases, including lung inflammatory diseases and respiratory virus infections. NGF can be produced and act upon both structural and non-structural cells of the airways, and overexpression of NGF causes morphological and physiological …
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TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
… a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), airway obstruction, wheezing, and leads to airway remodeling if these symptoms persist. Airway remodeling is characterized by goblet hyperplasia, airway smooth muscle hypertrophy and hyperplasia, subepithelial …
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Effects of vitamin D on inflammation and oxidative stress in airway epithelial cells
… that vitamin D may be beneficial in COPD. Airway epithelial cells play a central role in COPD pathogenesis and have been shown to constitutively activate vitamin D. This study investigated the effects of vitamin D on inflammation and oxidative stress in human airway epithelial cells, …
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Autoantibodies From Patients With Nonallergic Asthma Cause Cytotoxic Injury To Airway Epithelial Cells.
… Increased levels of IgG autoantibodies to airway epithelial cells in serum samples of nonallergic asthma compared to allergic asthma and healthy controls have been reported. And a possible involvement of autoimmune response against bronchial epithelial cell antigen in the pathogenesis of …
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Anti-allergic drug and intracellular signaling mechanisms in human blood eosinophils and airway epithelial cells,
… reported to inhibit cytokine production from T cells, suppress blood and tissue eosinophilia, inhibit IgE production, and prevent goblet cell metaplasia, it was my hypothesis that IPD inhibits a pro-inflammatory pathway in human blood eosinophils and airway epithelial cells involving G-proteins …
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Regulation of cAMP-Dependent Gene Expression in Airway Epithelial Cells: A Transcriptional and Pharmacodynamic Analysis
… bronchodilators that work by elevating cAMP in airway smooth muscle (ASM). Less appreciated and understood is the ability of cAMP to regulate gene expression. For example, previous studies have shown LABAs to protect ASM against pro-contractile stimuli by up-regulating RGS2, which attenuates …
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Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… cardinal features of asthma is the presence of airway remodeling, the structural changes that contribute to exaggerated narrowing of the airway. Fibroblast-to-myofibroblast transition (FMT) is an airway remodeling phenomenon whereby fibroblasts develop phenotypic characteristics of …
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The regulation and function of viperin during rhinovirus infection
The airway epithelium is the primary site of rhinovirus replication and plays a pivotal role in orchestrating innate immune responses to respiratory viruses, including rhinovirus. Interfacing with inhaled material in the airway lumen, the airway epithelium experiences continuous onslaught from …
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Cytokines and aeroallergens in the pathogenesis of summer-pasture associated obstructive pulmonary disease: effects on endothelin production, neutrophil activation and chemotaxis
… disease (SPAOPD), a naturally occurring airway disease of horses, is characterized by clinical exacerbation associated with exposure to pasture environment during the summer. Aeroallergens are believed to trigger exacerbation of SPAOPD, cytokines are likely associated with the anamnestic …
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
… adult lung, the BMP pathway is activated during airway inflammation. However, a role for activated BMP signalling has not yet been elucidated. The aims of this project were to identify a role for BMP signalling in adult airway epithelial cells (AECs) and to further investigate BMP signalling …
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Consequences and Limits of Cell-Cell Communication in Airway Immune Responses
The airways are an important barrier tissue, where successful immune responses can protect our bodies from viruses, bacteria, fungal spores, and environmental toxins. Conversely, when the immune system fails to respond or responds inappropriately in the airways, it can lead to diseases from deadly …
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Modulation of airway mucin glycosylation by Pseudomonas aeruginosa pyocyanin
… is provided by an overabundance of mucus in CF airways. When compared to that of non-CF individuals, mucus of CF airways has been found to be enriched in sialic acid, especially in the form of the tetra carbohydrate moiety sialyl-Lewisx, which is a preferred binding receptor for PA. Furthermore, …
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
… to increased Na+ absorption which contributes to airways dehydration, thickened mucus, impaired mucociliary clearance and is thought to be a major contributor to the pathogenesis of lung disease. Previous work has shown that QUB-TL1, an active site directed inhibitor of trypsin and trypsin-like …
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Mechanisms of virus infection of human airway epithelium cultured at an air-liquid interface (HAE-ALI)
ABSTRACT Polarized human airway epithelial (HAE) cultures are instrumental for studying respiratory tract diseases and gene delivery of airways. Primary epithelial cells isolated from tracheobronchial airways, grown in transwell at an air-liquid interface (ALI), undergo media-induced mucociliary …
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IMPACTS OF TROPICAL PEAT-FOREST SMOKE: URBAN PM2.5 AND TOXICITY IMPLICATIONS
… investigated using an in vitro model of small airway epithelial cells differentiated at air-liquid interface (S-ALI). Transcriptomic analysis identifies 273 dysregulated genes involving >60 signaling pathways. An alveolar-endothelial co-culture model further demonstrates epithelial exposure to …
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The regulation of human airway epithelial expression of viperin by human rhinovirus
… is a novel antiviral molecule that is induced in airway epithelial cells following HRV infection and that inhibits replication of HRV in these cells. We investigated the mechanisms of HRV-induced epithelial viperin expression, and the effect of cigarette smoke extract (CSE) on this expression. We …
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