Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"airway disease"”.
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Stem Cell and Biological Interventions to treat Allergic Airway Disease
… immune modulation with a particular focus on airway inflammation and allergic pathogenesis. This was probed in a model of pathogen driven immunomodulation (B. pertussis), and two models of therapeutic intervention namely immunisation (attenuated B. pertussis, BPZE1) or using a candidate cell …
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The regulation of allergic airway disease by type V collagen-induced tolerance
… IL-17 and prevents immune-mediated lung diseases. Objectives: Determine a role for anti-col(V) immunity in asthma. Methods: Serum anti-col(V) antibodies were measured in asthma patients, and immunohistochemistry utilized to detect interstitial col(V) in fatal asthma. Balb/c mice were …
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The role of IL-4 receptor alpha in chronic allergic airway disease (AAD)
Includes abstract.
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The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation
Allergic asthma is a chronic inflammatory airway disease driven predominantly by a TH2 immune response to environmental allergens. The asthma pathology is predominantly elicited by IL-4 and IL-13 signalling via IL-4Rα-signalling which is essential for driving TH2-type immunity to allergens. …
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Charakterisierung und Kausalitätsanalyse von Atemwegserkrankungen bei Mitarbeitern einer Viskosespinnerei
Several workers of a rayon factory suffered from airway diseases which were possibly related to occupational causes. This study compares the medical reports concerning these cases and balances private and occupational risks. It shows that in this factory adverse working conditions might be the …
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Aspects of laryngotracheobronchitis in African children
… is a relatively recent term for infective upper airway disease (Baum, 1924). Prior to this "croup" was used by both public and profession to describe a train of laryngeal symptoms which sometimes were due to infection. The word derives from the Anglosaxon "kropan" (Neffson and Wishik, 1934a) or …
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TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma
… cytokine IL-9 which has functions in allergic airway disease, helminth infections, and tumor immunity. TL1A increases IL-9 production from Th9 cells. However, its role in regulating other functions of Th9 cells is unknown. Here we demonstrate that TL1A increases expression of IL-9 and IL-13 as …
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The Clinical Spectrum, Aetiology and Disease Progression of Children with Post-infectious Bronchiolitis Obliterans at Tertiary Paediatric Pulmonology Service in Cape Town, South Africa
… is limited literature on chronic obstructive airway disease in the paediatric age group. Post-infectious bronchiolitis obliterans (PIBO) is a cause of obstructive airway disease children, with limited data in African children. Aim: To describe the clinical spectrum, aetiology, and disease …
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Computed tomography of cats without general anesthesia: feasibility, protocol development and assessment of cats with thoracic disease
… for imaging awake cats with signs of thoracic disease. The final diagnosis was obtained with cytology, histopathology, necropsy, or response to therapy. Cats were imaged in the VetMouseTrapTM using a 16 multi-slice helical CT system. The cats used in phase two served as control for imaging …
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Predictive genomics in asthma management using probabilistic graphical models
… and manifestation. Because most common diseases with high morbidity and mortality are complex traits, uncovering the genetic architecture of these traits is an important health problem. Asthma, a chronic inflammatory airway disease, is one such trait that affects over 300 million people …
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A microfluidic mucosal airway model to study airway mucosal function and pathogenesis
Airway mucus hypersecretion or impaired clearance is one of the key pathophysiological features of airborne infection, allergy and severe respiratory diseases. As foreign particles enter the lungs, the airway becomes inflamed and excessive amount of mucus is generated in response. However, little …
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The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease
… epithelial cell distribution throughout the airways. In the adult lung, BMP signalling is reactivated during airway injury and inflammation and there is evidence of aberrant signalling in lung cancer and in chronic lung diseases such as asthma and fibrosis. However, little is known about the …
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Investigation of immune responses in different mouse models of allergic asthma
Allergies are a common chronic disease and considerably decrease the quality of life for affected individuals. Understanding the immune responses during allergic diseases is essential for both diagnosis and the development of effective therapies. The route of sensitisation to allergens is one …
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Biomarkers of oxidative stress and inflammation in biological samples collected from recurrent airway obstruction (RAO)-affected horses and their controls
… used in human medicine to diagnose and monitor airway disease. The purpose of the study was to determine if similar relationships existed between inflammatory and oxidative stress biomarkers in exhaled breath condensate (EBC), bronchoalveolar lavage fluid (BALF), red blood cells, white blood …
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From sneeze to wheeze: Non-invasive studies on asthma and rhinitis
Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. Asthma is also closely …
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Cytokines and aeroallergens in the pathogenesis of summer-pasture associated obstructive pulmonary disease: effects on endothelin production, neutrophil activation and chemotaxis
Summer pasture-associated obstructive pulmonary disease (SPAOPD), a naturally occurring airway disease of horses, is characterized by clinical exacerbation associated with exposure to pasture environment during the summer. Aeroallergens are believed to trigger exacerbation of SPAOPD, cytokines are …
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Neuroinflammatory consequences of rhinovirus infection in the human airway
… (RV) is the leading cause of exacerbations of airway disease, during which the airways become hypersensitive and manifests clinically with troublesome bouts of cough. The mechanism responsible for respiratory virus induced cough in humans is unknown. This research aimed to determine whether RV …
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Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers
… industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. The general aim of this thesis was to find …
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The role of reactive oxygen species as mediators of respiratory syncytial virus induced pulmonary inflammation
… Although the mechanisms of RSV-induced airway disease are unknown, experimental evidence suggests that early local inflammatory processes serve as major initiating events in the pathogenesis of RSV-induced lung disease. RSV induced inflammation is mediated in part by small inflammatory …
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Sex and gender in chronic obstructive pulmonary disease
… sex and gender in chronic obstructive pulmonary disease (COPD) has primarily focused on differences in pulmonary function. Detailed gender- and sex-based analyses of other aspects of COPD, including epidemiology, risk factors other than cigarette smoke, pathophysiology, and measurement tools are …
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