Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ahpC"”.
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Identification and Characterization of Novel Melioidosis Vaccine Candidates
… through a review of the literature we identified AhpC as a potential protective antigen. AhpC is a constitutively expressed peroxiredoxin involved in oxidative stress reduction. We first inactivated AhpC by introducing a glycine substitution at Cys57 (AhpCC57G), which is the peroxidatic cysteine …
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Mechanisms of Oxidative Stress Resistance in Porphyromonas gingivalis W83
… on the alkyl hydroperoxidase subunit C <em>(ahpC)</em>and bacterioferritin comigratory protein <em>(bcp)</em> genes, DNA repair mechanisms and the unique hemin layer of <em>P. gingivalis. </em>We tested the physiological function of the isogenic <em>ahpC</em> and <em>bcp</em>mutants to …
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Distinguishing Medial Temporal Lobe and Prefrontal Cortex Contributions to Approach-Avoidance Conflict in Healthy Controls and Generalized Anxiety Disorder: Insights from Functional Magnetic Resonance Imaging and the Hierarchical Drift Diffusion Model
… PFC (DLPFC). While the anterior hippocampus (aHPC) supported evidence generation, perirhinal cortex (PRC) activity pointed towards threat perceptual processing and response caution. (2) There has been limited work stressing the mechanisms underlying AA conflict by testing it in samples with …
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Molecular analysis of small RNA and small protein regulation of Escherichia coli stress responses
… of approaches to uncover the novel targets ahpC and mdfA. While mutating ahpC has no effect on growth, mdfA (which encodes a proton/sodium/potassium antiporter) mutants partially rescue cell growth. Additionally, under alkaline conditions mdfA mutants expressing DicF are able to outcompete …
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Ochrobactrum anthropi: a soil bacterium for the study of Brucella virulence
… of alkyl hydroperoxide reductases encoded by ahpC and ahpD genes and their contribution to intracellular survival of Brucella were studied by over-expressing them. The recombinant O. anthropi expressing B. suis ahpC and ahpD genes were able to resist in vitro killing by H2O2 and or cumene …
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Oxidative stress responses in Campylobacter jejuni: the role of the Peroxide Regulator PerR
… the identification of PerR-repressed genes (e.g. ahpC, katA, trxB). Differential RNA sequencing was used to identify target promoters for PerR. Proteomics (2D gel electrophoresis) and gel shift assays were also used to confirm direct regulation by PerR. The combination of these technologies …
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Investigating the transcriptional regulation by OxyR in Porphyromonas gingivalis.
… of antioxidant defense genes like sod, ahpC-F, dps to protect the bacteria from oxidative stress. Expression of P. gingivalis OxyR regulon is not very well understood. Microarray studies carried out in our lab using P. gingivalis W83 to study gene regulation by OxyR, indicated that …
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Mesenchymal stem cells as trophic mediators of neural differentiation
… using the adult rat hippocampal progenitor cell (AHPC) line as a model system. Results obtained suggest that, under defined conditions, MSCs secreted a complement of soluble factors/cytokines that induce AHPCs to commit to and undergo astrogenesis. This effect was characterised at both the …
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Investigating the impacts of resistance mutations in Mycobacterium tuberculosis in order to improve the selection of new drug targets
… ACP synthase (KasA), alkyl hydroxide reductase (AhpC) and NADH dehydrogenase (Ndh) for INH resistance and RpoB and RpoC for RIF resistance. The impacts of mutations on the structure and function of these proteins were predicted using software developed in the Blundell group, including impacts on …