Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"agrp"”.
-
Neuronal cicuits and reinforcement mechanisms underlying feeding behaviour
… of homeostatic neurons— agouti-related peptide (AGRP) in the arcuate nucleus (ARC) and leptin receptor (LepRb) neurons in the lateral hypothalamic area (LHA)—in the control of food intake. First, I examined the role of LepRb neurons in the LHA in feeding. Results from electrophysiological studies …
-
Hypothalamic Nutrient Sensing
… heterogeneous population of neurons, including AgRP/NPY and POMC neurons. Using pharmacological tools, I demonstrated, unexpectedly, that this acute sensing is independent of mTOR and leucine metabolism, known pathways involved in leucine sensing in vivo. Leucine sensing is LAT1 independent. The …
-
Appetite Regulatory Neural Circuitry in the Prenatal Testosterone Treated and Obese Ewe
… brain which express both agouti-related protein (AgRP) and neuropeptide Y (NPY), or proopiomelanocortin (POMC) and cocaine- and amphetamine- regulated transcript (CART). We then asked whether this circuitry is altered in ewes at increased risk of obesity following prenatal testosterone (T) …
-
Amino acid transmitters and the neural control of feeding and energy homeostasis
… Neuropeptide Y / Agouti-related peptide (NPY/AgRP) and proopiomelanocortin (POMC) cells (the so-called first order feeding neurons), have been extensively studied for their roles in energy homeostasis—mostly through research into the peptides they are named after. There is clear evidence that …
-
Hypothalamic control of energy rheostasis during metabolic challenges, pregnancy, and lactation
… revealed that pregnancy increases AgRP neuron activity and decreases POMC neuron activity in the arcuate nucleus. Chemogenetic activation of POMC neurons or inhibition of AgRP neurons suppressed pregnancy-induced feeding, indicating that these changes are required for gestational …
-
The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
… populations in the ARC, agouti related peptide (AGRP) neurons and pro-opiomelanocortin (POMC) neurons. We employed a CRISPRbased gene editing strategy to selectively delete LepR in either AGRP or POMC neurons and found that leptin signaling loss in either population leads to same level of SNS …
-
Identification and Delineation of Neuronal Pathways Underlying Hypophagia
… the hypothalamus (ARC) agouti-related protein (AgRP) neurons are not essential for maintaining body weight in mice. Specifically, I found that the near-ablation of AgRP neurons had no impact on <em>ad libitum</em> food intake and survival, which overturned the dogma that adult deletion of these …
-
Molecular characterization in human neurons of genes associated with the control of bodyweight and feeding behaviour
… potential therapeutic targets to affect obesity. AgRP and POMC neurons in the hypothalamic arcuate nucleus show reciprocal response to feeding and fasting cues, so it can be speculated that reciprocally regulated genes in these neurons could have a role in regulating food intake and body-weight. …
-
Effect of age and pregnancy on the murine melanocortin system in the female reproductive system
… peptide (ASP) and agouti-related protein (AgRP) antagonise the peptide activity. The MCs were previously detected in the male mouse reproductive system, and their expression levels were found to be influenced by age. This thesis aims to investigate the expression of the MC system in the …
-
A Molecular Dissection of the Ventromedial Hypothalamic Nucleus
… of PRV Bartha2001 to trace neuronal inputs from AgRP neurons in the ARC using AgRP-cre mice. Using this technique, it could be determined that the dorsomedial and intermediate VMH sends significant outputs to this population of ARC neurons. This technique, together with the marker genes …
-
Growing Up POMC: Pro-opiomelanocortin in the Developing Brain
… and Neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons in the ARH exert opposing influences on secondary neurons in central circuits regulating energy balance. My thesis research focused on the developmental events regulating the differentiation and specification of cell fates in the ARH. …
-
Identifying key nodes in brain neural circuits controlling glucose homeostasis
… (Gck) -expressing agouti-related protein (AgRP) neurons. The enzyme Gck is well-known for its crucial role within the pancreas, where it enables sensing of glucose levels and leads to glucose-stimulated insulin release. Here, we demonstrate its importance for AgRP neuronal function by …
-
Restriction of Food Intake by Dorsomedial Hypothalamus
… acts in part by regulating the activity of AGRP neurons and POMC neurons in the arcuate nucleus and neurons in other brain regions. In these dissertation, I will describe how we identify novel neuronal populations that are regulated by leptin directly or indirectly. In order to identify …
-
Neural Mechanisms of Homeostatic Need and Reward
… of cell types: POMC and Agouti-related- peptide (AgRP) neurons in the hypothalamus. Activation of POMC neurons decreases food intake and resembles the state of food satiation, while activation of AgRP neurons drives food seeking and consumption and resembles the state of hunger. However, neuronal …
-
The Mechanism of Obesity in Rai1+/- Mice
… and the expression of Pomc, Mc4r, Bdnf, and Agrp. Treatment with ampakine drug may increase expression of Bdnf and help to control obesity in Rai1+/- mice.
-
Ghrelin: The Hunger Hormone that Isn't
… on a study by Luquet et al. which showed that AgRP/NPY neurons (which express the ghrelin receptor and are thought to be the critical target for appetite stimulation) can be ablated without consequence in neonatal mice, while in adult mice ablation causes a rapid and profound loss of appetite. …
-
Hypothalamic Regulation of Food Intake in Obese and Anorexic Avian Models
… stress in the LWS. The melanocortin system (AgRP and MC3R) changed in the hypothalamus after stress in the LWS, and hence may be responsible for the loss of responsiveness to exogenous NPY in stressed LWS. Experiment 5 was designed to evaluate whether hypothalamic differences exist at the …
-
Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide
… der Expression von Insulinzielgenen (POMC und AgRP) nachgewiesen werden. Das liegt wahrscheinlich an dem niedrigen Differenzierungsgrad der untersuchten Zellen. Im Rahmen der Adipositas kommt es zu einer Überaktivierung des Endocannabinoidsystems. Endocannabinoidrezeptoren sind mit den EP …
-
Mechanisms of hypothalamic regulation of food intake in birds
… factors, such as NPY and agouti-related peptide (AgRP). In Experiment 5, ICV injection of AM activated the ARC, the nucleus in which POMC and CART mRNAs were increased. In conclusion, these experiments revealed novel hypothalamic mechanisms underlying stress or exogenous neuropeptide-induced …
-
Lateral Parabrachial Choline Acetyltransferase Neurons and the Decision to Eat
Food choice is a modifiable health factor which involves neural, hormonal, and metabolic signals. The lateral parabrachial nucleus is a brain structure in the pons that integrates multiple aspects of food choice. It receives information from the homeostatic melanocortin hypothalamic system and …
Page 1 of 2