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Showing 1 to 6 of 6 for “"agr quorum sensing"”.
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Reconstitution and Mechanistic Studies on the Staphylococcal agr Quorum Sensing Circuit
<p>Quorum sensing (QS) plays a central role in virulence induction in the commensal pathogen, Staphylococcus aureus. This bacterium secretes an auto-inducer peptide (AIP), a small, cyclic peptide containing a thiolactone linkage as an indicator of its population density, and up-regulates virulence …
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Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection
… enhanced activation of the staphylococcal agr quorum sensing system during in vitro polymicrobial versus monomicrobial growth. Analyses by qPCR, Western blot, and toxin functional assays confirmed enhanced agr-associated gene transcription and increases in secreted α- and δ-toxins. C. …
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Mechanism of Signal Transduction By The Staphylococcus Aureus Quorum Sensing Receptor AGRC
… is carried out by the accessory gene regulator (agr) quorum sensing system. The agr autoinducing peptide (AIP) pheromone activates the AgrC receptor histidine kinase, resulting in downstream modulation of virulence factor expression. As S. aureus is a dangerous pathogen, understanding virulence …
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Effect of iron and haemoglobin on Staphylococcus aureus biofilms
… had different effects on the expression of Agr quorum sensing (QS), a regulator of biofilm dispersal, in a strain-specific manner. In Newman, haemoglobin significantly repressed elements of Agr QS system, whereas inorganic iron induced them. In the endocarditis isolate, provision of …
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Molecular investigation of the influence of environmental factors and subinhibitory antibiotic concentrations on the biofilm formation in Staphylococcus epidermidis
… subtilis. Construction and analysis of an agr-mutant in a biofilm-forming S. epidermidis strain excluded the possibility that the Agr-quorum-sensing system significantly contributes to the ica expression in the stationary growth phase. However, clear evidence was provided that in S. aureus …
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Studies on the Maturation of Secreted Quorum Sensing Peptides That Regulates S. Aureus Virulence
<p>The accessory gene regulator (agr) locus in the commensal human pathogen, Staphylococcus aureus, is a two-promoter operon with allelic variability that encodes a quorum sensing circuit involved in regulating virulence in the bacterium. Secretion of unique autoinducing peptides (AIPs) and …