Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"agonism"”.
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Agonism and Antagonism: Past and Future Possibilites of Radical Democracy
Though radical democratic theory has become a mainstay in progressive political thought, it is clear that more work needs to be done in terms of establishing the empirical bases for its appearance and continuation. As such, through a comparative investigation and analysis of historical episodes of …
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PPARγ agonism attenuates cocaine seeking behavior via association with ERK MAPK
… use and abstinence. Our lab demonstrated PPARγ agonism rescued cognitive impairment in an animal model of Alzheimer’s disease and that this rescue involved ERK. Given the role of altered learning and memory circuitry in addiction, and our recent evidence that PPARγ is involved in restoring …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… for treating this difficult disease. Mas agonism may be viable target serving as a broad therapeutic for ALS patients, regardless of disease type, due to its protective effect in common ALS mechanisms.
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Transparent animism: a framework for participating in ecological design as agonism
… to participate in ecological design as agonism. We are experiencing an anthropogenic ecological crisis and are in need of new ways to relate to the rest of the biosphere. Through animism, an ontological order where humans and nonhumans are both seen as subjects, and agonism, a political …
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Cardiovascular Effects of GLP-1 and Glucagon Dual Receptor Agonism in Humans
… actions of GLP-1 and glucagon receptor agonism are well studied, however less is known about their combination. This thesis reviews the discovery, background, physiology, metabolic and cardiovascular effects of these peptide hormones. The cardiovascular effects of GLP-1 and glucagon …
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ALPHA4BETA2 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS: FROM SUBTYPE SELECTIVE TO STOICHIOMETRIC ISOPHORM SELECTIVE PARTIAL AGONISM.
This PhD thesis focuses on the study of the α4β2 nicotinic acetylcholine receptors (nAChRs). This dissertation is divided into two parts. The first part is centred on the design, synthesis, and biological evaluation of compounds selective for the orthosteric and unorthodox binding sites of the α4β2 …
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The Dimension of Coercion in Chantal Mouffe's Theory of Agonism: Theoretical Reflections and Empirical Applications to Local Politics in the UK
… politics and pluralism. Focusing on Mouffe’s agonism and endeavours to apply this approach in empirical analysis, the thesis explicates its underlying ‘Ethics of the Real’ and elaborates a methodology centred on Poststructuralist Discourse Theory’s (PDT) ‘ontology of the lack’. Both concepts …
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Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
… HI and H2 receptor antagonists displayed inverse agonism whereby HI inverse agonists inhibited the phosphorylation of STAT1 in the absence of histamine. However H2 inverse agonists exhibited effects similar to the H2 agonists and augmented the phosphorylation of STAT1. Similar effects were …
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A TALE OF TWO STRESS MODULATORS: EFFECT OF DELTA OPIOID RECEPTOR AGONISM AND FKBP5 INHIBITION ON GENE EXPRESSION AND BEHAVIOR DURING COCAINE WITHDRAWAL
Addiction is characterized by compulsive drug use, loss of control over drug intake, and development of withdrawal symptoms when the drug is abruptly discontinued. The most substantial challenge for the treatment of substance use disorders is the prevention of relapse to further drug use once the …
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Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking
<p>L-3,4 dihidroxyphenylalanine (l-DOPA) strongly stimulates motor activity in parkinsonian patients and animal models of Parkinson's disease. Severe striatal dopamine (DA) loss characterizes Parkinson's disease and its animal models. Given the canonical rate model of Parkinson's Disease …
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Design and Syntheses of Potential Drugs Based on GABA(A) Receptor Pharmacophores
… at the murine GABAA receptor (GABAAR). The agonism of these GABA amides is comparable to that of THIP, as shown by in vitro assay results. The assay data indicate that the agonism of GABA amides is tether length-dependent. Optimum agonism is achieved with a tether length of four methylenes …
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Agonist-Induced Conformational Changes In The Nmda Receptor
… receptor and the mechanism controlling partial agonism. Past studies utilizing static structural snapshots of the receptor or isolated domains of the receptor have provided insufficient insights to fully understand these issues. Herein, I have conducted Förster Resonance Energy Transfer …
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FEMALE COMPETITION AND THE ROLE OF TESTOSTERONE IN A POLYGYNOUS SYSTEM
… hour, and higher-ranking females initiated more agonism than lower-ranking females. Testosterone appeared to play an important role in competitive ability. Immunoreactive fecal testosterone metabolites (fT) were strongly positively correlated to both dominance rank and number of agonistic bouts …
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FEMALE COMPETITION AND THE ROLE OF TESTOSTERONE IN A POLYGYNOUS SYSTEM
… hour, and higher-ranking females initiated more agonism than lower-ranking females. Testosterone appeared to play an important role in competitive ability. Immunoreactive fecal testosterone metabolites (fT) were strongly positively correlated to both dominance rank and number of agonistic bouts …
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The Role of Emotion Regulation in Promoting Prosocial Sibling Relationships
… of sibling relationship quality (warmth, agonism, and rivalry/competition). Participation in MFWSB was associated with improvements in down regulation for older, F (1, 76) = 11.87, p < .001, and younger, F (1, 76) = 9.49, p < .01, siblings, whereas children in the control condition showed …
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Socioecology of Adult Female Vervet Cercopithecus Aethiops and Patas Monkeys Erythrocebus Patas in Kenya: Food Availability, Feeding Competition, and Dominance Relationships
… vervet monkeys, but only when all food-related agonism was considered, including interactions that occurred in the A. drepanolobium habitat. In the riverine habitat, almost half of all female agonism among vervet monkeys was not food-related. The link between ecology and behavior at the level …
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Reframing Strategic Inertia: The Politics of Innovation and the Case of GM Biotechnology
… Political'. The thesis proposes a strategy of 'agonism' as an alternative. Rather than replacing one despotic concept with another, the suggestion of agonistic strategy is made because agonism allows for its own reinterpretation, thus does not represent a sedimented centre of a discourse. In …
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Exploring the immunologic consequences of ATRX deficiency in glioma
… innate immune signaling in response to PolyIC agonism and STING agonism, which was observed at the protein level, RNA level, and functional level via cytokine expression. The observed increase in immune signaling was dampened by IDH-mutation, and inhibition of mutant IDH relieved this …
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The oligodendrocyte lineage of the median eminence in the adaptation to diet-induced obesity
… mechanism explaining how the addition of GIPR agonism to GLP-1R agonist treatments for weight loss, to achieve dual incretin receptor agonism (IRA), can improve treatment efficacy has long been speculated to involve changes in central agonist signalling. As such, the possibility that GIPR …
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