Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"aglycone"”.
-
Progress Toward The Total Synthesis Of The Natural Product Herbicide Ascaulitoxin Aglycone
Ascaulitoxin aglycone is a structurally unique bis-amino acid isolated from the fungal species Ascochyta caulina, with herbicidal activity against Chenopodium album. Ascaulitoxin aglycone's potent herbicidal activity coupled with an unknown but novel mechanism of action makes it a perfect candidate …
-
Stability of bioactive isoflavones and glycolytic enzymes produced by probiotic bacteria in soy based food during processing and storage
… soy isoflavone glycosides to their bioactive aglycone forms. Fifteen probiotic micro-organisms that included Bifidobacterium sp., Lactobacillus acidophilus and Lactobacillus casei were screened for β-glucosidase activity using ρ- nitrophenyl-β-D-glucopyranoside as a substrate. Six strains were …
-
Bifidobacterial enzymic transformation of isoflavones, their bioavailability and effects on disease risk biomarkers in postmenopausal women
… 10% of total isoflavone in a biologically active aglycone configuration, with the remainder found as isoflavone glucoside conjugates. Saccharolytic enzyme-producing Bifidobacterium, classified as probiotics, are commonly incorporated into fermented milk products to enhance their health benefit. …
-
The Interaction of Equol and Genistein on Estrogen Dependent Tumors and Bones in Ovariectomized Athymic Nude Mice
… equol and total genistein (both conjugate and aglycone forms) were 1.18+/-0.24 hours (mean +/- STD) and 1.57+/-0.16 hours (mean +/- STD), respectively. The average aglycone forms of equol and genistein at 0.5h, 1h, 2h and 4h were approximately 0.5% and 5.6% of their total concentration, …
-
A comparative study of the phosphodiesterase 4 inhibitory activity of artemisia afra, Leonotis leonorus and mentha longifolia plant medicines
… with higher levels of total flavonoid and/or aglycone luteolin and/or hesperetin had higher PDE inhibitory activity.
-
A study of compounds having antibacterial activity isolated from Rubus pinfaensis Levl. et Vant.
… after enzymatic hydrolysis yielded a new aglycone, which has been named pinfaensic acid. Acylation and methylation yielded the methyl diacetoxy derivative, which was purified to allow its structural elucidation and hence identify the parent as glucosyl 23- …
-
Studies Towards The Novel Synthesis Of Benzoisochromane Quinone Polyketides
… and elegant synthesis towards the granaticin aglycone and other benzoisochromane quinone natural compounds with the long term aim of discerning the mechanism of glycosylation. This thesis shows a novel route for the synthesis of highly substituted isochromane and isochromane quinone compounds …
-
Toward the Synthesis of CAY-1, an Antifungal Steroidal Saponin
… end, methods for the preparation of they CAY-1 aglycone and pentasaccharide moieties have been investigated. Through this work, several partially protected stereoisomers of the CAY-1 aglycone have been prepared which can be used for the synthesis of saponin derivatives of CAY-1 for …
-
Development of a standardized functional soy product for cancer prevention trials:Phase II evaluation of isoflavone bioavailability in men with asymptomatic prostate cancer
… bread the isoflavone existed predominantly as aglycones (potentially most active and more readily absorbed). We hypothesized the aglycone-rich soy-almond bread compared to the glycoside-rich soy bread would provide greater bioavailable soy isoflavones which will have a greater effect on health …
-
Interactions of Anticancer Drugs With DNA Studied by High-Resolution NMR Spectroscopy
… and 1:1 WP631/d(CGJACG)$\sb2$ showed that the aglycone rings intercalate slightly shallower than those in the 2:1 DAU/d(CGTACG)$\sb2$ and the daunosamine moieties are elevated from the minor groove floor, which would explain why the binding constant of WP631 to DNA is 3 orders less than …
-
Effect of Soyasaponin Fractions on Human Colon Cancer Cells
… purified soyasaponins I and III as well as their aglycone form, soyasapogenol B, as anticarcinogenic agents on the human colon adenocarcinoma cell line Caco-2. Experiments were conducted to determine the effects of purified soyasaponins on cell proliferation, Protein Kinase C (PKC) activity, and …
-
The biosynthesis of ravidomycin
… Biosynthetic studies have shown that the aglycone unit comes from the folding of a polyketide chain with the vinyl unit arising from propionic acid. Since this vinyl functionality is believed to playa role in the antitumor activity of the antibiotic, it is of interest to elucidate the …
-
Flavonoid Glucosyltranferases: Cloning and Sequencing of Putative Glucosyltranferases from <em>Citrus paradisi</em> (Grapefruit) Leaves.
… sugar moiety from UDP-sugar is transferred to aglycone flavonoid substrates by glucosyltransferases (GTs). Grapefruit contains 5 different glucosyltransferases that demonstrate differences in not only substrate but also position specificity. Previous research obtained 3 putative 5’ grapefruit …
-
Interfacial properties of saponins from Quillaja saponaria Molina and their functionality in dispersed systems
… it is known that saponins with a triterpenoid aglycone form viscoelastic films, knowledge on corresponding foam properties is scarce. In the present thesis six saponins, which differed in molecular structure, were analyzed with respect to interfacial and foam properties. It was shown that high …
-
Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
… tetracene was converted to idarubicinone, an aglycone of the FDA approved anthracycline idarubicin, by a judicious orchestration of Co- and Ru-catalyzed arene oxidation and a novel dearomative hydroboration. This global functionalization strategy, a combination of site-selective arene- and …
-
Mechanism of Substrate Specificity and Catalysis in Retaining β-Glucosidases From Maize and Sorghum
… and others to investigate what determines the aglycone specificity in β-glucosidases, and how β-glucosidases catalyze the hydrolysis of β-glycosidic bond between sugar and aglycone moieties. Molecular modeling techniques allowed to predict the substrate binding sites in Glu1 and Dhr1. Based on …
-
The Isolation and Identification of the Anthocyanin in the Leaves of Oxalis Ortgiessi
… hydrolysis was carried out to identify the aglycone, glycosides and organic acid. Findings. The anthocyanin of the leaves of Oxalis ortgiessi was identified as malvidin-3-rhamnoglucoside-5-glucoside from the Rf values, spectral maxima and color observations. Conclusion. The anthocyanin of …
-
Total Synthesis of Mangrolide A
… group, mangrolide A could not generate the aglycone under acidic conditions. In another path, the desired product mangrolide A methyl ether was achieved along with several rearrangement products. Due to the lack of free hydroxy group at C11, the absolute stereochemistry could not be …
-
Isolation, Characterization, and Synthesis of Bioactive Natural Products from Rainforest Flora
… parissaponin Pb. Hydrolysis afforded its aglycone, the known spirostanol diosgenin. GCMS analysis characterized the derivatized, hydrolyzed sugars. Previous investigations of Albizia subdimidiata provided two saponins including the new compound albiziatrioside A. The sugar moieties of …
-
Maize β-glucosidase substrate specificity and natural substrates
… could cleave many glycosides with hydrophobic aglycones. One major substrate, the hydroxamic acid 2,4-dihydroxy-7- methoxy-1, 4-benzoxazin-3-one-8-D-glucopyranoside (DIMBOA-glc), was found in methanolic maize extracts. Increasing DIMBOA levels are associated with increasing resistance to …
Page 1 of 2