Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"aging brain"”.
-
Magnetic resonance elastography and nonlinear inversion problem in the aging brain
The history of medical imaging has centered on finding correlations between contrast in an image and diagnosis of a disease, but there is a shift in medical imaging from contrast towards quantitative measurements as disease biomarkers. Magnetic resonance elastography (MRE) is a non-invasive imaging …
-
Physical activity, cardiorespiratory fitness, memory, and self-efficacy in the aging brain
… (Bandura, 1977, 1997). However, the specific brain regions associated with self-efficacy and the implications such brain regions may have for memory task performance are unknown. In addition to self-efficacy, previous research has demonstrated that cardiorespiratory fitness (Colcombe, Kramer, …
-
MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
… mitochondrial function is associated with aging and is an early step in Alzheimer's disease (AD). Autophagy also declines with age and is required for degradation of dysfunctional mitochondria but it is not known whether autophagosomal formation is overactive and/or degradation of …
-
Dancing and the aging brain: the effects of a 4-month ballroom dance intervention on the cognition of healthy older adults
… in the world, the promotion of healthy aging and the development of interventions allowing an independent lifestyle in old age have become major public health issues. Particularly, dance has emerged as a useful tool in the fight against age-related decline, becoming a topic of increasing …
-
Age related memory loss and the role of the ubiquitin proteasome system
The hippocampus is a vital region of the brain directly involved in memory formation and spatial processing. As individuals age, this area undergoes significant structural changes, including a reduction in volume and modifications in molecular processes. These transformations are an inevitable …
-
Gamma and the senses : explorations of multisensory cognitive approaches in Alzheimer's disease
… progression. My research contribution to the Aging Brain Initiative, reveals the importance of multi-modal gamma stimulation for human-centered applications. This takes form within a novel sensory taxonomy of the effects of gamma entrainment stimuli in humans. Simultaneously, groundbreaking …
-
Sulforaphane as a potential nutritional intervention to reduce neuroinflammation associated with aging and sickness behavior
… Microglia, the resident innate immune cells in brain, recognize pathogens and danger associated molecular patterns, then express proinflammatory signaling molecules such as interleukin (IL)-1β, IL-6, and inducible nitric oxide synthase (iNOS). Aging is associated with chronic neuroinflammation …
-
Creative Aging: Functional Neural Networks Associated with Creativity in Aging
… ability has been implicated in successful aging including psychological, social, spiritual and, cognitive functioning (Duhamel, 2016). Creative thinking is associated with connectivity between default and executive control regions in the young brain. In aging, this pattern of functional …
-
A comparison of resultant fibrils upon environmental and sequential manipulations of α-synuclein, a Parkinson’s disease associated protein
… elevated levels of metals are found in healthy aging brain and in brain of patients with neurodegenerative diseases. In addition, mitochondrial deficiencies and oxidative stress caused by cytosolic acidification have been associated with several PD cases. Several efforts have been made to …
-
Effects of Alcohol Use on Cognition During Later Adulthood
… the effects of alcohol on cognition during aging difficult. The current study examined the relationship between drinking at three separate time points (between the ages of 50 and 74) and cognition in older adulthood. Results revealed that the quantity of self-reported drinks over the three …
-
Revealing the plastic brain with functional connectivity: effects of exercise on brain plasticity and cognition
… of the biological basis of cognitive aging and dementia, and important factors for their prevention, is essential for the development of low-cost prevention and treatment programs to address the aging crisis. For instance, although age is a prominent risk factor for AD, epidemiological …
-
Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System
… excitability and integrity of the Drosophila aging brain.
-
Transcriptional response to spatial learning and foraging in honey bees: molecular bases for adult neuroplasticity
… persistent neuroplasticity in the adult and aging brain. In many species, some types of neuroplasticity typically decrease with age. Honey bees and other social hymenopterans, however, exhibit a reinstatement of structural plasticity in association with flight and foraging behavior. Adult …
-
Sex Differences in the Relationship Between Physical Activity and Cognitive Health in Ethnically Diverse Older Adults
The global population is aging rapidly, accompanied by a rise in dementia cases, particularly among females and ethnic minority groups. Physical activity (PA) may mitigate the effects of aging on brain health and promote cognition in older adults, with benefits varying by biological sex and …
-
The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders
… and array genotyping on 1511 post-mortem brain samples within the MRC Brain Bank, we detected 61 monogenic cases of disease, 349 brains carrying disease risk factors, and identified that variants in GRN and PRPH may increase the risk of developing dementia with lewy bodies (DLB) and …
-
Morphological and functional study of cerebral aging in rat
Aging is a physiological process characterized by a progressive decline of the “cellular homeostatic reserve”, refereed as the capability to respond suitably to exogenous and endogenous stressful stimuli. Due to their high energetic requests and post-mitotic nature, neurons are peculiarly …
-
Lattice Boltzmann method for integrating the Bloch equation in muscle fibers and microvessels
… and are therefore largely associated with aging and obesity. Recent research has demonstrated that Magnetic Resonance Imaging (MRI) can measure the local properties of directional water diffusion and lipid concentration in the human muscle. Strong correlations have also been found between …
-
Effects of long-term hormone treatment on cognitive behavior and the structure of the medial prefrontal cortex during aging in female rats
… research has found that ovarian hormones alter brain structure and function. However, many studies evaluating the effects of estrogen and progesterone on brain structure have used young adult animals and have not administered medroxyprogesterone acetate (MPA), the most commonly prescribed …
-
Evaluating the cognitive benefits associated with an acting intervention: A brain-behavior framework
Purpose: Aging affects the configuration of large-scale functional brain networks with a corresponding decline in higher-order cognitive function. These cognitive changes can often compromise the ability to function independently. Previous research has suggested that the aging brain exhibits …
Page 1 of 2