Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"aggresome"”.
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The Systems Biology of the Protein Quality Control
… form a macroscopic cellular structure called "aggresome". Aggresome can arise in various stress conditions and may nucleate the formation of pathological aggregates in neurodegenerative diseases. In the second study, I establish the first in vitro model system to recapitulate the process of …
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Investigating dysregulation in protein quality control mechanisms in senescent cells
… that senescent cells displayed extremely delayed aggresome formation kinetics in contrast with proliferative cells. Aggresome formation dynamics were also altered by perturbations to the autophagy network. We further developed a live-cell fluorescent reporter of proteostasis using the …
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Loperamide enhances bortezomib-mediated cell death in colon cancer cells
… 11 J. shRNA-mediated knockdown of proteins 12 K. Aggresome staining 12 L. Flow cytometry for the analysis of DNA contents 13 M. Clonogenic cell survival assay 13 III. RESULTS 14 1. Synergistic cell death induced by loperamide plus bortezomib is neither apoptosis not autophagic cell death 14 2. …
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Modelling of colloidal dynamics in complex soft matter systems
… dynamics of a poly-glutamine agglomerate, named aggresome, in a mammalian cell: through a numerical solution of the advection diffusion equation, the macroscopic equivalent of the Smoluchowski equation, it has been possible to disentangle the relative importance of Brownian diffusion and active …
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Characterisation of a novel interaction partner for Atg16L1 and its role in regulating autophagy
… also able to recruit LC3 I, indicating a role of aggresome-like induced structures (ALIS). This thesis documents an interaction between Atg16L1 and MEKK4 that is vital for LC3 processing. The potential role for MEKK4 in regulating autophagy through Atg16L1 is discussed and experiments proposed to …