Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"aggrecanase"”.
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Mannosamine inhibits aggrecanase-mediated degradation of the mechanically functional portion of proteoglycans and of the physical properties of articular cartilage
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, February 2001.
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Enantioselective synthesis of cyclic beta-amino alcohols via tandem hydroalumination-cyclization-reduction of ethoxycarbonyl vinyl sulfoximines and application to the synthesis of potential aggrecanase inhibitors
… 1,2-amino alcohol in the synthesis of potential aggrecanase inhibitor is described.
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Optimizing chondrogenic factors and protein delivery methods for cartilage repair
… medium would affect matrix production and aggrecanase activity of human and bovine BMSCs in RAD and agarose hydrogels was tested. The effects of Dex were dependent on the hydrogel material and the species/age of the BMSCs. Importantly, Dex reduced aggrecanase-mediated degradation of matrix …
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In vitro models for injurious compression of bovine and human articular cartilage
… the activity and activation of ADAMTS-4 (aggrecanase-1) in the cartilage tissue, one of the major enzymes responsible for proteoglycan degradation. These results may help to identify some of the interactions between mechanical stimuli, joint tissue damage, and chondrocyte behavior which …
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Aggrecan fragments as biomarkers in osteoarthritis
… individuals with a wide spectrum of disease. Aggrecanases were found to dominate aggrecan proteolysis in disease, although a contribution of matrix metalloprotease (MMP) activity was noted. Western blot quantification in individual samples showed that the proportion of aggrecan released into …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… The collagenases (MMP-1 and MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5) are implicated in the development of OA because of their ability to degrade type 2 collagen and aggrecan. This project aims to identify compounds from the diet that could offer protection or slow the progression …
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In vitro models of cartilage degradation following joint injury : mechanical overload, inflammatory cytokines and therapeutic approaches
… TNFa and IL-6/sIL-6R interacted to cause aggrecanase-mediated proteoglycan degradation. Importantly, the combined catabolic effects of cytokines were highly potentiated by mechanical injury. Furthermore, cartilage degradation caused by the in vitro injury model appeared to be initiated at …
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In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids
… of aggrecan biosynthesis and degradation, aggrecanase cleavage of aggrecan, chondrocyte gene expression profiles and changes in cell viability (apoptosis) were observed. Results imply that appropriate biomechanical stimuli can be beneficial during rehabilitation for post traumatic OA (PTOA) …
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Die Wirkung mehrfach ungesättigter Fettsäuren auf Schlüsselproteine der Knorpeldegeneration in einem Modellsystem für die canine Osteoarthrose
… die Produktion von PGE und die Expression von Aggrecanase ADAMTS‑5. DHA hatte auf keinen der untersuchten Marker einen Effekt. Schlussfolgerungen: Zusammenfassend bestätigen die Ergebnisse dieser Studie die in Fütterungsversuchen dokumentierte positive Wirkung von n-3 PUFAs bei der caninen OA …