Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"agenesis"”.
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AGenesis: A Novel
AGenesis is a novel of "postmortal fiction" set entirely in an afterlife. Nessie, a recently dead woman, accidentally kills an already-dead man, and in the confusion that follows, sets out to discover how he could have died and what after-afterlife he might have gone to. During her travels, she is …
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Prism adaptation in a case of cerebellar agenesis
… boy, A.C., with near complete cerebellar agenesis allowed us to determine whether cerebellar structures are critical for prism adaptation to occur. A.C. was tested on two separate occasions, twice using his left hand, and once using his right hand. He wore prism goggles while pointing to a …
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Diseño, desarrollo y validación de un tornillo híbrido para prótesis provisionales en pacientes con agenesis dentaria en dentición mixta
A la ausencia congénita de algún diente se le denomina agenesia dental. Los dientes principalmente involucrados son los terceros molares, los incisivos laterales superiores y los segundos premolares. Afectan a la población infantil de tal forma que pueden generar problemas de tipo estético, …
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Tratamento ortodôntico de pacientes com agenesia de incisivos laterais superiores
The "agenesis" term is attributed to non-development of one or more teeth – up to six. Genetics and inheritance are the main etiological factors of dental anomalies, especially agenesis. The most affected elements are the third molars often followed by lower premolars, maxillary lateral incisors …
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The Role of PTF1A in Spinal Cord Development
… in permanent diabetes mellitus and cerebellar agenesis. We show that PTF1a is present in precursors to GABAergic neurons in both the cerebellum and the spinal cord dorsal horn. A null mutation in Ptf1a reveals its requirement for the dorsal horn GABAergic neurons. Specifically, PTF1a is …
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The role of N-cadherin and S1P/S1P1 in pancreas development
… deficient-embryos suffer from dorsal pancreas agenesis due to apoptosis of the mesenchyme surrounding the pancreatic epithelium. N-cadherin-deficient embryos expressing N-cadherin or E-cadherin ectopically in the heart rescue dorsal pancreas formation, indicating that the phenotype is secondary …
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Dental Development in a UK Population: Does Ethnicity Matter?
… Hypodontia, with or without third molar agenesis (TMA), was approximately twice as likely in the White British group compared to the Black British group, and TMA only was approximately three times as likely. Developmentally missing teeth were shown to be associated with delayed third …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… characterized by pancreatic and cerebellar agenesis. DNA binding and transcriptional activity of PTF1 is dependent on the interaction of P48 with either RBP-J, or its paralogue, RBP-L. The exclusive form of PTF1 in mature pancreatic acinar cells is a potent transcriptional activator …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
… displays a subpenetrant phenotype of kidney agenesis. In this thesis work, results demonstrate the ability of the LRP4 extracellular domain to not only bind a broad variety of soluble ligands in the extracellular space, but further to influence the Wnt, and possibly others, signaling pathways …
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Analysis of the Function of Megf7 During Development
… kidneys and was paralyzed at birth. The kidney agenesis is the result of a failure of the ureteric bud to grow and branch during the initial stages of kidney development. The phenotype of the Megf7EC Stop and Megf7KO mutants prompted us to look for natural mutants in other animals. We found that …
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Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
… kidney developmental anomalies including renal agenesis, hypoplasia, and cysts. Here, I studied interacting proteins and target genes to understand the function of HNF-1Beta in the kidney. Yeast two-hybrid screening was performed to identify binding partners of HNF-1Beta in the kidney. Zyxin and …
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The Functional Roles for SWI/SNF Chromatin Remodeling Complexes in Physiology and Disease
… intellectual disability, and corpus callosum agenesis. In addition, ARID1B is the most common cause of Coffin-Siris Syndrome, a developmental delay syndrome characterized by some of the above abnormalities. However, its role in pathologies is not well characterized due to absence of in vivo …
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Roles in Retinoid Signaling in the Lower Urinary Tract
… urinary tract defects such as kidney and ureter agenesis, hydronephrosis, and vesicoureteral reflux. Development of the lower urinary tract, which consists of the kidneys, ureters, bladder, and urethra, is crucial for removal of toxic substances from the blood and depends on patent connections …
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The role of transcription factor GATA6 in the development of the human pancreas
… models for certain disorders such as pancreatic agenesis, the focus of my project. The use of site-specific nucleases such as TALENs for such a purpose represents a paradigm shift in disease modelling, where TALENs are capable of directly correcting disease-causing mutations, therefore …
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Primate-specific KRAB zinc finger proteins and their targets rewire regulatory networks related to inflammation and pancreas development
… knock out in patients diagnosed with pancreatic agenesis, presenting neonatal diabetes with insufficient pancreatic exocrine function. Expression and ChIP data for ZNF808 show that it is upregulated during the early stages of pancreatic development and binds on members of primate conserved MER11 …
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Novel mechanism in astrocyte gene regulation and function
… severe neuroanatomical defects including partial agenesis of the corpus callosum and hydrocephalus, however the target genes of NFI-X in the CNS remained elusive. Here, we show for the first time that YKL-40 is a novel target gene of NFI-X in astrocytes and controls their migration. In addition, …
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Investigating the control of epithelial polarisation in human kidney organoids
… hypoplasia or, in extreme cases, complete renal agenesis. In this thesis, I have investigated the control of the PTA-RV transition as it relates to human kidney development, using human kidney organoids as a model. Grown from induced pluripotent stem cells, intermediate mesoderm-like cells are …