Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"age-related diseases"”.
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Computational studies on ageing and age-related diseases
Age is the major risk factor for a variety of non-communicable diseases. As life expectancy increases, ageing poses significant challenges to the individual, society, and healthcare systems. Ageing is a complex process involving multiple interconnected cellular and organismal phenotypes. Thus, …
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Cell-intrinsic and-extrinsic mechanisms in the modulation of ageing and age-related diseases
Tesis doctoral con mención internacional
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The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis
… results in mortality. Since the associated diseases of aging are highly prevalent in the geriatric population, targeting the aging process as a whole may provide a better way to delay these age related diseases, in turn delaying aging. Various interventions have been shown to delay aging and …
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The Current Role of Kynurenine Pathway Interventions in Oxidative Stress and Redox Homeostasis in the Context of Aging and Cancer
… of death in the United States and in Europe. Age is the single highest risk factor for developing cancer, and more than half of cancer diagnoses occur after age 70. Most cancer therapeutics are studied in younger and healthier individuals, excluding the impact that age-related comorbidities …
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EVIDENCE SUPPORTING THE UTILITY OF BLOOD CELL RESPIRATORY CAPACITY AS A SYSTEMIC MARKER OF MITOCHONDRIAL HEALTH AND BIOLOGICAL AGE
… mitochondria are implicated in nearly all age-related diseases, currently there is no clinically useful measure of systemic mitochondrial health. Multiple lines of evidence suggest that blood cells may recapitulate mitochondrial function systemically, but there is a gap in the knowledge as …
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Respiratory muscle work and inspiratory muscle training on cytokines, oxidative stress and diaphragm fatigue in younger and older populations
… inflammation contributes significantly to the ageing process and age related diseases. Enhanced oxidative stress, glycogen depletion and diaphragmatic fatigue are all potential stimuli for this production. Whole-body exercise training can attenuate systemic inflammation and oxidative stress in …
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Mass Spectroscopic Identification and Quantification of Protein Carbonyls
… stress plays a critical role in aging and age-related diseases. Among the post-translational protein modifications, carbonylation has attracted a great deal of attention due to its irreversible and irreparable nature. Despite the fact that protein carbonylation is associated with a series …
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THE EFFECTS OF ACCEPTANCE AND COMMITMENT TRAINING ON RECALL IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT AND DEMENTIA
… population is aging. One of the most prevalent age-related diseases is dementia. Dementia is a disease that affects remembering behaviors which in turn affects every aspect of an individual’s quality of life. Currently there is no cure for dementia, however treatment success encompasses …
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Loss of Mismatch Repair in the Aging Human Hematopoietic Stem Cell
… and to prevent the expensive and debilitating diseases associated with increased age is an ongoing focus of scientific study. In the introduction chapter of this dissertation, I present a philosophical argument suggesting aging and age related diseases are a result of intraorganismal genetic …
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Design and Prototype of an Active Knee Exoskeleton to Aid Farmers with Mobility Limitations
… continue to get older, they will likely face age-related disabilities that impede their ability to work and increase risk of suffering serious injuries. One of the major age- related diseases is arthritis, which currently accounts for about 40% of disability cases in agriculture nationwide. …
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Postprandial Effects of Pecans Ingestion on Plasma Level of Nutrients, Polyphenolic Compounds and Biomarkers of Antioxidant Status in Human Volunteers
… may contribute to a reduction in chronic and age-related diseases.</p>
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A high-content multiplexed screening platform for the evaluation and manipulation of force and fatigue of adult derived skeletal muscle myotubes in defined serum-free medium
… Drug Administration (FDA). Also, the study of age related diseases as well as the potential for “personalized medicine” relies on the proliferation and maturation of satellite cells from adult derived tissue. For that purpose, a serum-free medium and culture system was designed to create mature …
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The Role of Amino Acid Transport in the Regulation of mTORC1 by Metformin
… most widely prescribed drug treatment for the management of type 2 diabetes mellitus. Despite being prescribed for over 50 years, the precise molecular mechanisms underlying metformin’s therapeutic effects remain poorly understood. Newly recognised health benefits of metformin, irrespective of …
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Association of early-life tobacco exposure with Cardiovascular-Kidney-Metabolic (CKM) syndrome risk : is accelerated biological aging a mediating pathway?
… is a well-established risk factor for age-related diseases, but its associations with proteomic aging and Cardiovascular-Kidney-Metabolic (CKM) syndrome severity, and whether optimal modifiable risk factors can attenuate the aging associations, remain unclear. In this cross-sectional …
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Novel Roles for A-Type Lamins in Maintaining Genomic Stability
… associated with a wide variety of degenerative diseases which range from muscular dystrophies and lipodystrophies to premature aging syndromes. In addition, alterations in the expression of A-type lamins are associated with different cancers such as small cell lung carcinoma and gastrointestinal …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… from glycolysis, is associated with various age-related diseases including diabetic complications and neurodegenerative diseases. Aging and long-term hyperglycemia causes enhanced production of this highly reactive α-dicarbonyl, which reacts with macromolecules causing irreversible damage of …
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Novel Proteases That Regulate Interleukin-1 Alpha Activity During Inflammation And Senescence
… of multiple inflammatory and autoimmune diseases including atherosclerosis, arthritis and cancer. Therefore, understanding the mechanisms that regulate IL-1a activity is extremely important. For many years, pro-IL-1a was considered to be a fully active alarmin. However, we have previously …
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Identifying a common cause of the loser cell status in Drosophila melanogaster.
… and at the onset and during the progression of diseases including cancer. However, if we are to exploit competition in the treatment of human pathologies and in tissue regeneration, we still have a lot to learn about the underlying mechanisms that ultimately instruct the elimination of loser …
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How to Mend a Broken Mitochondrial Genome: Mitochondrial Recombination And Its Applications
… mtDNA mutations are linked to mitochondrial and age-related diseases. Therefore, safeguarding mechanisms are crucial to limit mtDNA mutations and curtail ageing and disease. Yet, pathways that repair animal mtDNA double-strand breaks remain uncharacterised. Double-strand breaks can be accurately …
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Hypothalamic Transcriptional Profiling and Quantitative Proteomics of Mice under 24-Hour Fasting
… can increase the life span and the resistance to age-related diseases. MicroRNAs are highly conserved non-coding RNA molecules with a length of 21-23 nucleotides. Recent studies show that numerous microRNAs are associated with the regulation of oxidative stress, inflammation, insulin signaling, …
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