Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"age-related cognitive decline"”.
-
Moderation of age-related cognitive decline in older adults
Prior research has demonstrated a general decline in cognitive performance with age, especially in Fluid Intelligence. This study sought to find a way to slow, halt, or reverse the age-related decline in Fluid Intelligence. Participants aged 50 and older with no prior experience working crossword …
-
Identifying Factors Underlying Resilience to Age-Related Cognitive Decline
… episodic memory abilities can exhibit early declines. Evidence suggests that distinct components of episodic memory retrieval may be differentially impacted by age. In particular, the precision of memories shows detectable declines as early as midlife, whereas the ability to successfully …
-
The molecular and behavioral characterization of cav1.3 over-expressing mice
<p>Age-related cognitive decline refers to the memory impairment and difficulty learning new tasks that occurs during the normal process of aging. There are many possible changes that occur at the neuronal level that could account for age-related cognitive decline. One hypothesis suggests that a …
-
Studies on the effect of growth hormone on age-related changes in glutamatergic transmission in the hippocampus
… by the pituitary, has been implicated in cognitive processing and maintenance of hippocampal function. Hippocampal function is mediated primarily by the AMPA and NMDA glutamatergic receptors, and these receptors are important for the basal synaptic transmission and long term potentiation …
-
COGNITIVE DECLINE WITH AGE: ROLE OF STRIATAL CHOLINERGIC SYSTEM AND GROWTH HORMONE
Normal aging can result in cognitive decline even in the absence of neurodegenerative disease. Successful identification of neurobiological changes that occur in association with age-related cognitive decline is needed to develop strategies to restore or preserve cognitive function in elderly …
-
THE EFFECTS OF SOCIAL DRINKING IN OLDER AGE ON COGNITION AND BRAIN HEALTH
… consumption (7-21 drinks per week) in older age (≥ 65 years old), and the overarching goal was to determine whether or not it is associated with exacerbated age-related cognitive decline and brain changes.
-
The Relationship between Physical Activity, Depressive Symptoms, and Cognitive Functioning
<p>The number of older individuals experiencing age related cognitive decline (ARCD) continues to grow exponentially. Memory, executive functioning, and cognitive processing speed have shown to be particularly sensitive to the effects of aging. The same regions of the brain associated with …
-
Sarcopenia and cognitive ageing: investigating their interrelationship, biological correlates and the role of glucocorticoids
Background Sarcopenia and age-related cognitive decline (ARCD) are important age-related conditions which significantly impact upon the quality of life of older adults. ARCD is a well-established research area, whereas sarcopenia is a relatively new field. Research into the inter-relationships …
-
A role for nutrition in healthy brain aging
Nutritional cognitive neuroscience is an emerging interdisciplinary field of research that seeks to understand nutrition’s impact on cognition and brain health across the life span. While accumulating evidence indicates healthy cognitive aging is dependent upon both brain health and nutritional …
-
Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
… to be a critical factor in the development of age-related cognitive decline and Alzheimer’s disease (AD). As such, aberrant brain insulin signaling has been posited to lie at the crossroads of metabolic and cognitive disorders. In recent years, a greater focus has been placed on using insulin …
-
Effects of healthy ageing on the precision of episodic memory
Episodic memory decline is one of the hallmarks of human cognitive ageing, but our understanding of the neurocognitive mechanisms underlying this decline remains limited. In particular, it is unclear whether healthy ageing differentially affects distinct components of episodic memory retrieval; …
-
Age related memory loss and the role of the ubiquitin proteasome system
… formation and spatial processing. As individuals age, this area undergoes significant structural changes, including a reduction in volume and modifications in molecular processes. These transformations are an inevitable aspect of the natural aging process, occurring in individuals regardless of …
-
An integrated neurovascular investigation of cognitive aging
Age-related declines in cognition are associated with widespread structural and functional brain changes, including changes in resting state functional connectivity (rsFC) and gray and white matter status. In addition, research has demonstrated that individual variance in cognitive aging is …
-
Lifestyle factors and neuroimaging metrics as predictors of cognitive performance in healthy aging
Despite all the advances made in health-related and psychological sciences, advancing age continues to be accompanied by cognitive decline. Aging is usually associated with major changes in the structure and functioning of the brain that lead to impairments in multiple cognitive functions. The …
-
Examining the Effects of transcranial Electrical Stimulation on Vigilance and Attention
… Failure of such mechanism can result in cognitive deficits, real-world consequences like accidents and injuries; and are often prominent in disorders like narcolepsy, insomnia, Alzheimer’s disease, autism spectrum disorders, age-related cognitive decline, and schizophrenia.</p> …
-
Cerebrovascular influence on brain and cognitive aging
… in severe adverse effects on brain health and cognitive aging. Recently, Fabiani et al., (2014) introduced a novel non-invasive approach of quantifying cerebrovascular health using diffuse optical imaging in a sample of older adults. This method is based on the estimation of the arterial pulse …
-
Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
… is the major neurobiological substrate of age- related cognitive decline during “healthy” aging. According to this hypothesis, cerebrovascular (e.g. chronic cerebral hypoperfusion) and molecular (e.g. APOE, epigenetics) factors might contribute to age-related white matter pathology and …
-
Investigating coordination between stress-induced translational and transcriptional attenuation
… ISRIB treatment has been shown to improve age-related cognitive decline in mice. ISRIB treatment is also neuroprotective in prion diseased mice. Although ISRIB has not been shown as a human therapeutic, the use of ISRIB in mouse models exemplifies the importance of the ISR in …
-
Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… Americans have AD, with 5.1 million older than age 65 and 200,000 under 65. That accounts for 1 in 8 adults over 65. Furthermore, AD costs Americans 148 billion dollars in direct expenses, and is the leading cause of dementia and the 6th leading cause of death. Since improved medical care in …
-
The Neuroprotective Effects of Exercise Against Menopause Induced Alterations in Alzheimer’s Disease Neuropathogenesis
… effects on tissues in the brain by aiding in cognitive function, exerting anti-inflammatory effects, promoting neuronal synaptic activity, and regulating energy biosynthesis. These effects are lost when circulating ovarian hormones are decreased. Additionally, during the perimenopausal …
Page 1 of 2