Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 167 for “"age-dependent"”.
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Modelling the age-dependent dynamics of clonal haematopoiesis
… across healthy tissues and contributes to both ageing and cancer development. In blood-producing stem cells, this process, known as clonal haematopoiesis (CH), can often be detected years before the onset of haematological cancer, raising the possibility that individual cancer risk could be …
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Computerized rotational head impulse test : age-dependent normative data
… in healthy participants in each decade age band of life; 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, and 70+ years. Seventy-seven community-dwelling participants (10 to 85 years) with normal lateral SCC functioning and no symptoms or history of vestibular dysfunction, were recruited …
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Age-dependent regulation of hippocampal excitatory synaptic transmission by leptin
… excitatory synaptic transmission in an age-dependent manner at Schaffer collateral (SC)-CA1 synapses (Moult and Harvey, 2011). In addition, recent evidence indicates that leptin can also regulate synaptic transmission at the anatomically distinct input to CA1 neurons, the temporoammonic …
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PTH RESISTANCE SYNDROMES: AGE-DEPENDENT CLINICAL PICTURE AND EMERGING UNCOMMON FEATURES
… and more complex, with high variability and age-dependent presentation. A diagnostic delay is commonly reported; thus, our studies aim to describe some emerging uncommon clinical features with the final goal to improve diagnostic and management of these syndromes. METHODS: We conducted three …
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Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex
GABAA receptor binding is transiently increased in rat whisker barrels during the second postnatal week, at a time when neurons in the developing rat cortex are vulnerable to excitotoxic effects. To test whether these GABAA receptors might serve to protect neurons from excessive excitatory input, …
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Microgravity Exerts an Age-Dependent Effect on Cardiovascular Progenitor Cell Development
… of protein kinase C alpha (PKCα), a calciumdependent protein kinase, and Akt, a regulator of stem cell self-renewal, after 30 days. To explore the effect of calcium induction in neonatal CPCs, we activated PKCα using hWnt5a treatment on Earth, which resulted in an induction of early …
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Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation
… (U) body burden by measuring chromosome damage in peripheral blood lymphocytes with the cytokinesis blocked micronucleus assay (CBMN) and fluorescence in situ hybridization (FISH) whole chromosome painting. Study subjects are Gulf War I Veterans exposed to DU during friendly fire incidents …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
<p>An organism’s age impacts its susceptibility to disease, which varies according to the type of insult or causal pathogen. Much work remains to delineate these complexities, especially within younger individuals. Indeed, pediatric disease-driven immunity is less characterized than adult and aging …
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Age-dependent changes in the mouse lymph node and implications for immune responses
… microenvironment to determine whether there are age-related alterations and if so, whether and how these might contribute to the diminished antibody production in aged individuals. The first step of an immune response in the lymph node starts with the entry of antigen to the tissue. Antigens …
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Sexual Dimorphism in Susceptibility to Age-Dependent Metabolic Disorders in Mice Born through ICSI
… (NC). Our results revealed a sex-, and age-dependent predisposition of metabolic disorders. While ICSI males displayed insulin insensitivity at 3 and 10 months of age, ICSI females showed both impaired glucose tolerance and insulin insensitivity at the same two timepoints. Interestingly, …
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
… metabolic disease, mitochondrial dysfunction and ageing as independent risk factors for arrhythmogenesis beyond the risk they confer to coronary artery disease. To date, researchers have focused upon investigation of monogenic ion channel disorders as well circumscribed diseases to investigate the …
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Availability Analysis for the Quasi-Renewal Process with an Age-Dependent Preventive Maintenance Policy
… described by a quasi-renewal process with and age-dependent preventive maintenance policy. In addition, numerical results from various theoretical distributions are obtained to illustrate the behavior of the models. The two equivalent point availability functions each contains an infinite sum …
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Age-Dependent Determinants of Blood-Derived Monocytes Influence Neuroinflammatory Milieu at the TBI Injury Site
… corpses and concurrently resolving inflammation. Age-at-injury profoundly effects TBI recovery outcomes also. The phenotypic and functional plasticity of blood-derived monocytes (BDMs), as well as prior studies relating age and BDM activity, place BDMs at the crossroads these two advantageous …
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Age-dependent effects of chronic amphetamine on prelimbic-nucleus accumbens circuit function and goal-directed behavior
… to be a target influenced by repeated AMPH in an age-of-exposure dependent manner, which results in abnormalities in the reward circuit function and goal-directed behavior. Using a rat model, this hypothesis was tested with three specific aims: (1) to investigate the ontogeny of this LTD function …
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Strain-dependent and age-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.
… somatic signs and increased anxiety. Strain-dependent effects of acute nicotine and nicotine withdrawal on contextual fear conditioning were observed in several inbred strains. However, the effects of acute nicotine on contextual fear conditioning were not associated with the effects of …
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Age-Dependent Variability in Immune Host Responses to SARS-CoV-2: Implications for Inclusive Clinical Trial Design
… risks to aging populations, exacerbated by age-associated immune dysfunction, or immunosenescence. This dissertation investigates the immune responses that contribute to protection against SARS-CoV-2 and how these responses become dysregulated with increasing age. Given the evidence of …
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White storks (Ciconia ciconia) of Eastern Germany: age-dependent breeding ability, and age- and density-dependent effects on dispersal behavior
… and dispersal behavior can be determined by the age of the individual. Age-dependent as well as density-dependent dispersal patterns are common in many bird species. In this thesis, I first present age-dependent breeding ability and natal site fidelity in white storks (Ciconia ciconia); migratory …
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