Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 60 for “"age at diagnosis"”.
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Exploring the Relationship Between Psychological Resources and Breast Cancer Survivorship using Path Analysis
… (intrapersonal, interpersonal and informational) have the ability to influence cancer survivorship. Unknown is how these resources impact the length of survival. A predictive correlational design was used to study the psychological resources of 34 women who were breast cancer survivors …
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Outcomes and Management of Type 2 Diabetes in India and China
… This thesis examines various aspects of the management and outcomes of type 2 diabetes mellitus in these populations. In India, the objective was to examine the associations between diabetes and cardiovascular mortality (due to ischemic heart disease and stroke), and between self-reported …
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Genetic Testing Uptake and Yield in Patients with Male Breast Cancer
… breast cancer (MBC) risk is significantly elevated by germline predisposition, most commonly in <em>BRCA1</em> and <em>BRCA2</em>. Despite established guidelines recommending germline testing for all patients with MBC, there is wide variability in the reported prevalence of germline pathogenic …
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Impact of Childhood Acute Lymphoblastic Leukemia and its Treatment on Social-Emotional, Intellectual, and Academic Abilities
The occurrence of psychological late effects resulting from the diagnosis and treatment of pediatric acute lymphoblastic leukemia (ALL) been the subject of empirical investigations for approximately 25 years, with an emphasis on those patients treated with radiation therapy. In more recent years, …
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The Impact of Study Methodology on Studying Genetic and Environmental Risk Factors for the Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD), comprised of Crohn’s disease and ulcerative colitis, results from a complex interaction between genetic and environmental factors. NOD2 and cigarette smoking are two of the most commonly replicated genetic and environmental risk factors, respectively, for Crohn’s …
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Quantification of Major BCR-ABL1 Fusion Gene Transcripts for Monitoring Therapeutic Response to Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia; Comparison of LightCycler t(9;22) Quantification Kit and BCR-ABL1 Mbcr IS-MMR Dx Kit.
… monitoring, standardize BCR-ABL1 quantification and International Scale (IS) has been suggested, and this study is to compare IS-based IS-kit with non-IS-based LightCycler-t(9;22) Quantification kit (LC kit; Roche, Germany) for determination of MMR status. METHODS: We used stored RNA …
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Affect of‘Age at Diagnosis’on Coronary Arterial Lesions in Patients with Incomplete Kawasaki Disease
"Backgroud: Diagnosis of Kawasaki disease (KD) is based on 5 clinical features. Incomplete KD (IKD) with a fewer features is more common in infants and older children, in whom the rate of coronary artery aneurysms is paradoxically higher. This study was designed to evaluate between the age at …
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Genetic polymorphisms in breast cancer in relation to risk and prognosis
… by environment, lifestyle, genetics and a combination of these factors. In this thesis work the combination of lifestyle and genetic polymorphisms on tumor characteristics and early recurrence have been studied. Absence of the common 19 CA repeat allele in the insulin-like growth factor 1 gene …
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Parent perceptions of the quality and availability of early intervention services for children with autism spectrum disorder in Saudi Arabia
… responsiveness, curriculum, training, and engagement) and needs (need for information, training, support, financial assistance, and quality services), the study utilized a survey to gather responses from 401 participants receiving services from eight institutions located in three Saudi Arabian …
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Lateral Distribution and Recurrence of Ovarian Endometrioma
… The main target of this study is to evaluate the correlation between the lateral distribution and recurrence of ovarian endometrioma. MATERIALS AND METHODS: The 371 patients who were diagnosed as ovarian endometrioma through pathology in Ajou University Hospital during from May 1994 to …
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Paediatric brain tumours: The University of Cape Town experience from 1996 - 2017
… being made over the last 2 decades, patient outcomes in general remain poor when compared with other childhood cancers. Optimal treatment of children with brain tumours is challenging and expertise and resources are not widely available in South Africa. This is important because the …
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Health management of adult hypertension in the United States: Results from the National Health and Nutrition Examination Survey (NHANES)
This research is a comprehensive study that describes how individuals with hypertension do their health behaviors and how their behaviors change over time based on their diagnostic status and the duration of hypertension. The Dietary Approaches to Stop Hypertension (DASH) diet is a widely used …
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Employment quality in adult survivors of childhood cancer
… cancer can have lower employment participation outcomes including employment quality. This study is aimed to identify factors that predict employment quality in this growing population. Methods: Retrospective cohort study of 296 currently employed adult survivors of childhood malignancy …
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Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas
… system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia development and glioma pathogenesis. In this …
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Correlation of HAS2-associated gene duplications with biological aggressiveness of mast cell tumors in Chinese Shar-Pei dogs
… of excessive dermal hyaluronan, a protein associated with angiogenesis and tumor cell motility in multiple human and canine neoplasms. Cutaneous mucinosis in Shar-Pei has been associated with gene duplications upstream of the hyaluronic acid synthase 2 gene (HAS2). The objective of this study was …
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Sequential improvement in paediatric medulloblastoma outcomes in a low-and-middle-income country setting over three decades
… malignant brain tumour of childhood. Accurate clinical data for paediatric MB in the LMIC setting is lacking. Sequential improvements in outcome seen in high income countries are yet to be reflected in LMIC. Aim: Quantification of paediatric MB outcomes in the LMIC setting over three …
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An audit of the management of women with Borderline Ovarian Tumours treated at Groote Schuur Hospital between 1984-2008
… Borderline ovarian tumours (BOT) are an intermediate form of neoplasia, between benign and malignant and have been classified as epithelial tumours of low malignant potential. These particular tumours affect a younger age group than their invasive counterparts with an overall survival of 90 - …
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A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population
… factors for long-term outcomes in osteosarcoma patients are still controversial. There is no literature available regarding these factors in a patient population in a developing country. Objectives: To determine the outcome of treatment of osteosarcoma patients treated at Groote Schuur Hospital …
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Evaluation of prognostic risk factors at diagnosis and treatment outcomes in adult patients with early-stage hodgkin lymphoma in Cape Town, South Africa
The National Comprehensive Cancer Network (NCCN) Guidelines are a recognized standard for prognostic staging in Hodgkin Lymphoma (HL). We aimed to determine if the NCCN staging system and its individual risk factors correlated with patient treatment outcomes in early-stage adult classical HL (cHL) …
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Risk of Second Malignant Neoplasms Following Proton Arc Therapy and Volumetric Modulated Arc Therapy For Prostate Cancer
… second malignant neoplasms (SMNs) following prostate radiotherapy is a concern due to the large population of survivors and decreasing age at diagnosis. It is known that parallel-opposed beam proton therapy carries a lower risk than photon IMRT. However, a comparison of SMN risk following proton …
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