Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"afterload"”.
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Mechanical Property and Phenotype Characterization of an in vitro Model for Afterload-triggered Cardiac Hypertrophy
… revealed that conditions that increase cardiac afterload, like obesity and hypertension, worsen HCM patients’ prognosis. Among research models of HCM, in vitro models that use patient-derived induced pluripotent stem cell (iPSC) differentiated cardiomyocytes are especially promising because the …
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Hemodynamic outcomes of weaning intraaortic balloon counterpulsation in heart failure
… hemodynamic indices reflecting contractility, afterload, and preload were measured during the final one-minute for each stage of the weaning protocol. Descriptive statistics were used to determine the patterns of measurements over the nine stages for each group. To determine main effects and …
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The Impact of Prolonged Strenuous Exercise on Right Ventricular Structure and Function: Insights from Novel Echocardiography and Electrocardiography
… a recent theory suggests that an elevated afterload on the RV and subsequent interaction between the ventricles may be implicated. Based on this, the aims of this thesis were: 1) to assess the RV structural and functional response to a 100 mile ultra-marathon applying novel techniques to …
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Left ventricular function after ultra-distance triathlon : response is dependent on the cardiac loading conditions
… have not controlled for either preload or afterload or both, before and after exercise. These studies may rather have identified the effects of alterations in peripheral vascular function on left ventricular function after prolonged exercise. The research study in this thesis is to evaluate …
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A Novel Trajectory Vector Approach for Characterizing Dynamic Changes in the Performance-Load Representation of Cardiac State
… metrics of preload to be correlated with afterload, combining both types of load into a more comprehensive general cardiac load. Through a series of controlled animal studies, we collect hemodynamic data during baseline and various pharmacological interventions while the animal is …
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
Increases in cardiac afterload caused by disease conditions results in remodeling of heart structure by hypertrophy and alterations in the molecular regulation of contractile performance. These adaptations can be regulated by various Ca2+-dependent signaling processes. STIM1 is an important …
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Enalaprilat Improves Systemic and Mesenteric Blood Flow During Normotensive Resuscitation from Hemorrhagic Shock in Dogs
… to be due to prevention of the increases in afterload noted in the controls. Comparison of monitoring techniques, showed stronger correlation between the ultrasonically determined descending thoracic aortic blood flow and celiac artery flow than between thermodilution determined cardiac …
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Muscle Metaboreflex Control Of Coronary Blood Flow And Ventricular Contractility During Dynamic Exercise In Normal And Heart Failure Conditions
… in heart rate, ventricular contractility and afterload. This increase in cardiac work should cause coronary metabolic vasodilation. However, little if any coronary vasodilation is observed due to concomitant sympathetically induced coronary vasoconstriction. In heart failure, cardiac output …
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Haemodynamic consequences of Spinal Anaesthesia for non-emergency Caesarean section
… preload. Spinal anaesthesia was associated with afterload reduction, which was more pronounced in healthy patients than in preeclamptics. Ephedrine maintained or increased, and phenylephrine reduced maternal cardiac output in healthy patients. Oxytocin was associated with transient haemodynamic …
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Elucidating the roles of endothelial PTBP1 and PKM2 in Pulmonary Arterial Hypertension: implications for therapy
… pulmonary arterial pressure, right ventricular afterload, and heart failure. Pulmonary artery endothelial cell (PAEC) dysfunction is regarded as a key driver of the disease and is characterised by heightened proliferation and development of apoptosis resistance. Dysfunctional metabolism also …
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The Role of Metabolic Inflexibility in Heart Failure
… to increased cardiac work due to pressure afterload. This revealed that cardiac energetic deficiency did not require hypertrophic growth, and hypertrophic growth was not blunted by lack of glucose oxidation. Taken together, these findings suggest that metabolic inflexibility in …
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The effect of alcohol intoxication on haemodynamic physiology of acute cardiac tamponade
… decreasing peripheral vascular resistance and "afterload". It is also possible that inhibitory actions on the respiratory centre may prevent hyperpnoea or tachypnoea, and thereby diminish competitive filling of the right and left ventricles. However, further studies of cardiac function in …
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Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
… arterial pressure and right ventricular afterload ultimately causes death by right heart failure. Current available treatments show little impact on patient mortality and there is thus an urgent need to better understand the causes of PAH pathology to derive new transformative therapies. …
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Vascular and metabolic profile of 5-year sustained hypertensive versus normotensive black South Africans
… stroke and heart failure, as it increases the afterload on the heart, as well as creating a higher pulsatile load on the microcirculation. The stiffness of the carotid artery is associated with cardiovascular events, like stroke, and all-cause mortality. Furthermore, carotid stiffness is …
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Mechanisms Mediating Modulation Of The Cardiopulmonary Chemoreflex Control Of Regional Sympathetic Outputs By Adenosine A1 And A2a Receptors In The Nts
… may have beneficial effects when it decreases afterload and heart rate thus decreasing oxygen demand. However, strong activation of the CCR may cause severe bradycardia and hypotension leading to hypoperfusion of vital organs, fainting and even death. During this severe reflex hypotension …
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The utility of bioimpedance cardiography in assessing the influence of obstructive sleep apnea hypopnea syndrome on cardiac function
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) is a breathing disorder characterized by recurrent episodes of upper airway collapse during sleep. Measuring cardiac function in OSAHS patients may provide information to help delineate not only chronic effects of autonomic imbalance and ventricular …
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Assessment of Cardiac Function by Acoustic Radiation Force (ARF) Based Methods of Ultrasound Elastography
… advantages. 1) Parameters including preload, afterload, and coronary perfusion can be accurately controlled. 2) The heart’s left ventricular free wall can be easily imaged from multiple angles. 3) Confounding neurohormonal reflexes of the body can be eliminated. </p><p>SWEI measurements of …
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Development and Application of Low-Order Computational Models of the Left Ventricle
… to accurately represent the preload and afterload systems of the LV if LV function is altered. In the second, we show that interactions between the right and left ventricles have a pronounced effect during diastole. In the third, we demonstrate that, according to the coupled mathematical …
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Parameters and algorithms to evaluate cardiac mechanics by conductance catheter
… with heart rate, contractile state, preload and afterload. The present observation, which shows the compensatory mechanism of mechanical dyssynchrony, suggests that ventricular dyssynchrony may be regarded as an intrinsic cardiac property, with baseline dyssynchrony at increased level in heart …