Global ETD Search
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Showing 1 to 6 of 6 for “"afterhyperpolarization"”.
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Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation
<p>One of the most characteristic features of pyramidal cells in the prefrontal cortex (PFC) is that they present a slow afterhyperpolarizing current (I<sub>sAHP</sub>) that plays a critical role in the regulation of neuronal excitability. This current is modulated by receptors acting via …
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Calcium Regulation of a Slow AHP in Hippocampal Pyramidal Cells
A slow afterhyperpolarization (sAHP) in CA1 hippocampal pyramidal cells is calcium-dependent and involves activation of KCa3.1 and KCNQ potassium channels. Both KCa3.1 and KCNQ channels bind calmodulin (CaM) as a calcium sensor, with an additional role proposed for the protein hippocalcin. We …
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PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons
… One of these mechanisms is the Ca2+-dependent afterhyperpolarization (AHP), which activates during bursts and causes spike frequency adaptation. This afterhyperpolarization has three distinct conductances: a fast component (fAHP) underlain by BK channels, a medium component (mAHP) underlain by …
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Modulation of Axonal Transmission by Metabolic Stress
… nickel exposure also significantly increased the afterhyperpolarization (AHP) that could be caused by blocking T-type calcium channel. However, removal of extracellular calcium failed to confirm the presence of a calcium channel as it did not mimic exposure to divalent cation. Persistent and …
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Ion channels and electrical excitability in native murine anterior pituitary corticotrophs
… When A-type potassium channels were blocked, the afterhyperpolarization amplitude of single spikes was decreased in some corticotrophs. In native murine corticotrophs, outward potassium current carried by large conductance calcium- and voltage- activated potassium (BK) channels was very low, which …
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Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease
… firing frequency by blocking KCa-mediated afterhyperpolarization. When slices were treated with a low dose of rotenone, L-DOPA activated KATP channels in both SNc and LC neurons. A higher dose of L-DOPA was required to activate KATP channels in nigral non-DA neurons. This indicates that …