Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"afferent neurons"”.
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Naᵥ1.8+ Visceral Afferent Neurons: Roles in Metabolism and Inflammation
… of inflammatory signaling pathways. As vagal afferents are a neuronal population that can rapidly respond to both food-related stimuli as well as inflammatory agents and cytokines, I hypothesized that intact vagal afferent function may be required for proper regulation of energy balance and …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… recordings carried out from rodent primary afferent neurons using the in vitro skin nerve preparation in an attempt to reveal mechanisms underlying thermal sensitivity. The discovery of thermally sensitive transient receptor potential (TRP) ion channels has given insights into the molecular …
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Synaptic Specificity in the Zebrafish Lateral Line
… developmental challenge, requiring billions of neurons to select their appropriate synaptic targets. In view of this complexity, simple vertebrate systems provide necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of …
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Synapse Formation in the Zebrafish Lateral Line
… anteriorly and posteriorly polarized cells. Afferent neurons form synapses with hair cells of only one subpopulation, and this polarity-specific innervation arises independently of synaptic activity. The research presented in my thesis deepens the understanding of synapse formation in the …
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Development of a chronically implanted microelectrode array for intraneural electrical stimulation for prosthetic sensory feedback
… of sensory information directly to the sensory afferent neurons of the transected peripheral nerve in the stump of the amputee. lntraneural implants of several designs were developed and implanted in rabbit animal models and monitored for chronic functionality evaluated using both …
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Exercise Pressor Reflex Dysfunction in Hypertension
… III) and metaboreflex (predominantly group IV) afferent fibers, which are activated by mechanical stress and the metabolic byproducts of working muscle, respectively, project to the nucleus tractus solitarius (NTS) in the brainstem. Within this nucleus, nitric oxide (NO) is produced from …
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Mouse Embryo Development in the Presence of Capsaicin
… the degranulation and degeneration of C-afferent neurons. Capsaicin is widely used as a food condiment and medicine. Human exposure of capsaicin can exceed levels shown to be neurotoxic in laboratory animals. Additionally, capsaicin can cross the blood/placenta barrier and affect an …
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Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level
… nervous system (CNS) via axons of primary afferent sensory neurons residing in dorsal root ganglia (DRG). Inhibition of pain signals directly at the spinal level provides an opportunity to reduce pain at the most basic level. Several G protein-coupled receptors, including opioid and …
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Pain-modulating effects of peripheral (CB2) cannabinoid receptors
… to inhibit the responsiveness of primary afferent neurons.
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Sensory Neurogenesis and the Role of PRDM12 in Nociceptor Development and Function
Nociceptors are a set of peripheral neurons responsible for the detection of noxious stimuli. They function to alert us to the presence of potentially damaging internal and environmental threats, thereby playing an important role in allowing us to react and avoid danger. Unfortunately, for over 30% …
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Frequency Selectivity of Synaptic Exocytosis in Hair Cells of the Bullfrog's Amphibian Papilla
… frequency constituents. Individual auditory afferent neurons of the VIIIth cranial nerve respond best to a particular frequency of stimulation, and are thus frequency-tuned. Much of the tuning in the inner ears of mammals is ascribed to the frequency dependence of the traveling waves on the …
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Mechanical Control of Sensory Hair-Bundle Function
… analogous to the electrical excitability of neurons. This behavior implies for the first time a direct relationship between the mechanical behaviors of sensory organelles and the electrical behaviors of afferent neurons. Man-made detectors function in limited capacities, each designed for a …